HIV-1 budding, a novel target for therapeutics
David Ajasin*, Vasudev R. Rao*, Xuhong Wu, Santhamani Ramasamy, Mario Pujato, Arthur P. Ruiz, Andras Fiser, Anne Bresnick, Ganjam V. Kalpana and Vinayaka R. Prasad (2019) CCL2 Mobilizes ALIX to Facilitate Gag-p6 Mediated HIV-1 Virion Release. eLIFE (in press).
Arthur P. Ruiz, David Ajasin, Santhamani Ramasamy, Eliseo Eugenin and Vinayaka R. Prasad (2019) A Naturally Occurring Polymorphism in the HIV-1 Tat Basic Domain Inhibits Uptake by Bystander Cells and Leads to Reduced Neuroinflammation. Scientific Reports 9:3308
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Rao, V. R., Sas, A., Eugenin, E., Siddappa, N. B., Bimonte-Nelson, H., Berman, J., Ranga, U., Tyor, W. R. and Prasad, V. R. (2008) HIV-1 clade-specific differences in the induction of neuropathogenesis. J. Neurosci. 28:10010-6.
RNA aptamers targeted to HIV-1
Duclair, S., Gautam, A., Ellington, A. and Prasad, V. R. (2014) High affinity RNA aptamers against HIV-1 protease inhibit both in vitro protease activity and late events of viral replication. Mol. Ther. Nuc. Acids. 4:e228. doi: 10.1038/mtna.2015.1.
Ramalingam, D, Duclair, S., Datta, S., Ellington, A.D., Rein, A. and Prasad, V. R. (2010) RNA aptamers directed to HIV-1 Gag bind to the matrix and nucleocapsid domains and inhibit virus production. J. Virol. 85:305-314.