Research in the Department of Cell Biology is focused on understanding molecular mechanisms of gene regulation in eukaryotic cells. Using mammalian cells, yeast, viruses, fruit flies and transgenic mice, we are investigating mechanisms of DNA replication and repair, control of the cell cycle and apoptosis, roles for transcriptional regulation and chromatin structure in gene expression, RNA processing, intracellular trafficking, membrane fusion and budding, mechanisms of generating antibody diversity, and the functions of cell surface sugars.
In the News
On Dec 8th, the Department of Cell Biology would like to congratulate Dr. Rebecca Brown, a Postdoctoral Fellow in the laboratory of Dr. Margaret Kielian, who has been awarded a Ruth L. Kirschstein NRSA F32 Postdoctoral Fellowship from the NIH.
On Nov 17th, Dr. Margaret Kielian presented the Keynote Lecture at the 18th Annual Norman P. Salzman Memorial Symposium at NIH. This annual meeting was established to honor the memory of Dr. Norman P. Salzman, one of the pioneers of molecular virology and a founding editor of the Journal of Virology. It is also widely considered to be the premier virology symposium hosted at the NIH.
Dr. Britta Will, Assistant Professor in Medicine and Cell Biology, is the recipient of a three-year Foundation Scholars Award from the Alexandrine and Alexander L Sinsheimer Fund. The fund was made to support her study on how transcriptional and epigenetic dysregulation drives cancer stem cell formation in leukemia. Congratulations.
The Department of Cell Biology would like to congratulate the following four Predoctoral Fellows and their laboratories who received NIH Predoctoral Fellowship Awards.
Ali Zahalka -- NIH NRSA F30 Individual Predoctoral Fellowship Award for a project entitled "Contributions of sympathetic signals to prostate cancer progression" (Sponsor, Paul Frenette, Cell Biology) .
Sean Healton -- NIH NRSA F30 Individual Predoctoral Fellowship Award for a project entitled "Epigenetic activity of normal and cancer-associated mutant H1 linker histones" (Sponsor, Arthur Skolutchi, Cell Biology).
Cary Weiss -- NIH NRSA F30 Individual Predoctoral Fellowship Award for a project entitled "MicroRNA-22 and the microRNA-22/tet2 network as regulators of the cell fate decision in hematopoietic stem cells and in the development of myelodysplastic syndrome" (Sponsor, Keisuke Ito, Cell Biology).
Ruth Howe -- NIH NRSA F30 Individual Predoctoral Fellowship Award for a project entitled "Characterizing the Novel Protein C15ORF65" (Sponsor, Ulrich Steidl, Cell Biology).
Congratulations to Dr. Ulrich Steidl on his promotion to the rank of Professor of Cell Biology and Medicine! This is a very well deserved recognition of the outstanding productivity of his research program and his numerous contributions to and leadership in Einstein’s teaching and research programs.
The Department of Cell Biology would like to congratulate Dr. Elena Tosti, a Postdoctoral Fellow in the laboratory of Dr. Winfried Edelmann, who has been awarded a fellowship from the Department of Defense.
Congratulations! Dr. Ulrich Steidl, Associate Professor in the Department of Cell Biology and Medicine, has been honored with election to the prestigious American Society for Clinical Investigation (ASCI). The society was established in 1908 and is one of the nation's oldest and most respected medical honor societies.
The Department of Cell Biology would like to congratulate Dr. Dachuan Zhang, a Postdoctoral Fellow in the laboratory of Dr. Paul Frenette, who has been awarded of the 2016 Julius Marmur Research Awards for his proposal, “Neutrophil aging is regulated by the microbiome".
Welcome New Cell Biology Faculty! Britta Will, Ph.D. was appointed assistant professor in the Departments of Medicine and Cell Biology in December 2015.
Dr. Will received her Ph.D. training at Harvard Medical School and the University of Freiburg, Germany. Prior to this appointment, Britta did outstanding research on the regulation of normal hematopoietic and malignant stem cell function under Dr. Ulrich Steidl’s mentorship.
Her research program dissects how age-related changes in gene-regulatory mechanisms contribute to hematopoietic stem cell failure and malignant transformation and exploits a combination of genetic mouse models, primary human specimen and cutting-edge molecular and cell biological assay systems.
Dr. Will’s laboratory is located in Room 401 of the Chanin Building. [web page]
The Department of Cell Biology would like to congratulate Dr. Arthur Skoultchi, Chairman of the Department, who is the recipient of the 2015 Faculty Mentoring Award.
The ceremony will be held at 4:30PM, December 10, 2015, in Lubin Dining Hall.
Dr. Kira Gritsman, Assistant Professor in Medicine and Cell Biology, is the recipient of a 3-year Sinsheimer Scholar award. The grant was made to support her research on the roles of PI3 Kinase in myeloid leukemia cells and their bone marrow niche. Congratulations!
The Department of Cell Biology would like extend a very warm welcome to our newest faculty member, Associate Professor Dr. Matthew Gamble. Dr. Gamble has been on the faculty in the Department of Molecular Pharmacology since 2009. He was recently promoted to Associate Professor of Molecular Pharmacology and he will join our department with a secondary appointment as Associate Professor of Cell Biology. Several labs in our department have already had very fruitful interactions with Dr. Gamble and his lab members. Dr Gamble’s research interests include mechanisms of mammalian gene regulation at the levels of transcription and splicing, chromatin structure and function and their impact on malignant transformation, cellular senescence and DNA repair mechanisms, with a focus on the role macro domain-containing proteins. His laboratory is located in 203 Golding Building.
The Department of Cell Biology would like to congratulate Michael Willcockson, an MD/PhD student in the laboratory of Dr. Arthur Skoultchi, who has been awarded an NIH Ruth L. Kirschstein NRSA Predoctoral Fellowship for his proposal, “Regulators of the Erythroid Terminal Differentiation Decision and their Connection to the Cell Cycle".
Britta Will, Instructor in Cell Biology, has received a prestigious 2-year research grant from the Aplastic Anemia & MDS International Foundation. She will use the funding to characterize molecular abnormalities in HSCs of patients with myelodysplastic syndrome in order to develop mechanism-based therapeutic approaches.
Inaugural Honoree — The American Association of Immunologists (AAI) has selected Dr. Matthew Scharff as the first-ever recipient of its inaugural 2015 AAI-BioLegend Herzenberg Award, which he will receive this spring during a special session at IMMUNOLOGY2015™. The honor recognizes an individual who has made exemplary research contributions to the field of B cell biology. Dr. Scharff is world-renowned as a pioneer in the development and application of monoclonal antibodies, which have become a cornerstone in biomedical research. He is distinguished professor of Cell Biology and of Medicine, as well as the Harry Eagle Chair in Cancer Research/National Women's Division and faculty supervisor of the Hybridoma and Tissue Culture Facility. The AAI-BioLegend Herzenberg Award was established, with support from BioLegend to honor the memory of AAI member Dr. Leonard A. Herzenberg.
Congratulations to Dr. Travis Bernardo and Dr. Barnali Biswas for winning Postdoctoral Fellowship awards!
Dr. Travis Bernardo, a Postdoctoral Fellow in the Skoultchi lab, is the recipient of a Ruth L. Kirschstein NRSA F32 Fellowship from the NIH.
Dr. Barnali Biswas, a Postdoctoral Fellow in the Stanley lab, is the recipient of a Postdoctoral Fellowship from The Lalor Foundation.
On 5/6/2015, Dr. Pamela Stanley gave a lecture in the NIH Director's Wednesday Afternoon Lecture Series (WALS), which is the highest-profile lecture program at the NIH. Her lecture was entitled “ Glycans that regulate development and notch signaling”.
Dr. Barbara Birshtein has been selected as this year’s recipient of the LaDonne H. Shulman Award for Excellence in Teaching. The recipient of this award is nominated and selected by the graduate students as a faculty member who has demonstrated exemplary skill in teaching and mentoring.
Of special note: This is the second time that Barbara has received this award!
Congratulations to Barbara on this very appropriate recognition of her dedication and teaching and mentoring skills by the graduate students.
Election to fellow is an honor bestowed upon American Association for the Advancement of Science (AAAS) members by their peers. In 2014, 401 AAAS members were awarded this honor because of their scientifically or socially distinguished efforts to advance science or its applications. Among the six AECOM faculty members who received this distinction, three are members of the Department of Cell Biology.
Margaret Kielian, Ph.D. – Elected for distinguished contributions to the field of virology, particularly for studies on the alphavirus and flavivirus membrane fusion proteins and on virus entry and exit. Dr. Kielian is Professor of Cell Biology and Samuel H. Golding Chair in Microbiology.
Richard Kitsis, M.D. – Elected for distinguished contributions to fundamental and translational aspects of cell death, particularly for originating and driving the field of cell death in the heart. Dr. Kitsis is Professor of Medicine and of Cell Biology, the Dr. Gerald and Myra Dorros Chair in Cardiovascular Disease and Director of the Wilf Family Cardiovascular Research Institute at Einstein and attending physician, cardiology at Montefiore Medical Center.
Robert Singer, Ph.D. – Elected for distinguished contributions to the development and application of imaging technologies and insights into the kinetics and spatial distributions of single mRNAs in living cells. Dr. Singer is Professor and Co-Chair of Anatomy & Structural Biology, Professor of Neuroscience and of Cell Biology, Co-Director of the Gruss Lipper Biophotonics Center and of the Integrated Imaging Program, and the Harold and Muriel Block Chair in Anatomy & Structural Biology.