Rose F. Kennedy Intellectual and Developmental Disabilities Research Center




 Dr. Noboru Hiroi, Ph.D. (PI) 

Social Communication in Genetic Mouse Models of Autism

Genetic risk factors do not necessarily result in autism and even when they do, severity varies widely among individuals. Given that early intervention modifies the severity of autism and that environmental factors are likely modifiers of outcome, this project will help establish how the interplay between genetic factors, early social communication, and neonatal maternal care determines the severity of autism-like behaviors via epigenetic mechanisms using three well-established mouse models of autism-associated genetic variants. The project has high translational value because it could provide mechanistic bases for symptomatic variability and lay the ground work for early therapeutic intervention. This project was funded for five years, starting August 1, 2017 through July 31, 2022 by the NIH’s National Institute on Deafness and other Communication Disorders.

Solomon Moshé, M.D. and Aristea Galanopoulou, M.D., Ph.D. (PIs)
Einstein-Montefiore to Play Leadership Role in $21 Million NIH Grant to Study the Onset of Epilepsy after Traumatic Brain Injuries 

Theodore Kastner, M.D., M.S. (PI)
Albert Einstein College of Medicine and Montefiore Health System Receive $3.5 Million Award for Training Leaders in Intellectual and Developmental Disabilities  

Steven Walkley, D.V.M., Ph.D. (PI)
Albert Einstein College of Medicine Receives Major Federal Grant for Research into Intellectual and Developmental Disabilities 

Ana Francesconi, Ph.D. (PI) 
Metabotropic glutamate receptor functions in autophagy
NIH R01 MH108614 
07/1/2016 – 06/30/2021

Mark Mehler, Ph.D. (PI) 
Molero, Aldrin
Huntington's disease: a novel developmental oligodendrogliopathy
NIH R01 NS096144
04/01/16 – 03/31/21

Eliana Scemes, Ph.D. (PI)
Importance of pannexin to astrocyte and neuronal ATP signaling
NIH R01 NS092786  
07/1/2016 – 06/30/2021

Steven U. Walkley, D.V.M., Ph.D. (PI)
Gene therapy studies in Mucolipidosis IV disease
ML4 Foundation 
06/01/16 – 05/31/18

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