A postdoctoral position is open in the laboratory of Dr. Charles E.Rogler to carry out investigations into the mechanisms of miRNA action in liver stem cell differentiation. A foundational publication ( Hepatology, 2009, see below) has established an experimental system for miRNA regulated differentiation of liver stem cells to either the hepatocytic or bile ductular cell fates. Initial investigations demonstrate that TGFb signaling molecules, Smads, are targets of differentially expressed miRNAs. This position will carry out investigations to uncover molecular mechanisms of miRNA regulation of the important TGFb signaling pathway and effects on stem cell fate.
Applicants should have a broad base of experience in biology, molecular genetics and biochemistry. Albert Einstein College of Medicine is an equal opportunity employer. Please send CV and names of referees to charles.rogler@einstein.yu.edu.
Charles E. Rogler, PhD
Professor of Medicine and Microbiology/Immunology
Department of Medicine
Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Bronx, NY 10461
Tel: 718-430-2607
Relevant Rogler Laboratory miRNA Publications.
1. Landgraf, P., et al A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing.
Cell 129:1401-1414, 2007.
2. Rogler, C.E., Zhou, H.C., LeVoci, L. and Rogler, L.E. Clonal, cultured, murine fetal lever hepatoblasts maintain their liver specification in chimeric mice. Hepatology, 46:1971-1978, 2007.
3. Connolly, E., Melegari, M., Landgraf, P., Tchaikovskaya, T., Tennant, B.C., Slagle, B.L., Rogler, L., Zavolan, M., Tuschl, T., and Rogler, C.E. Elevated expression of the miR-17-92 polycistron and miR-21 in hepatocellular carcinoma contributes to the malignant phenotype. Am J Pathol. 173:856-864, 2008
4. Rogler, C.E. MicroRNAs make inroads into liver development. Gastroenterology 136:770-772, 2009
5. Rogler, C.E., Levoci, L., Tchaikovskaya, T. and Rogler, L.E. MiR-23b cluster miRNAs regulate TGFß/BMP signaling and differentiation of liver stem cells by targeting Smads. Hepatology 50:575-584, 2009