October 14, 2015—(BRONX, NY)—A pair of neurons has been found in the brain of male nematode worms that allow them to remember and seek sex even at the expense of food. These neurons, which are male-specific, are required for sex-based differences in learning, suggesting that sex differences in cognitive abilities ...read more
New Approaches to Deep-Tissue Imaging—Near infrared fluorescent proteins (NIR FPs) are probes that allow for optical imaging of molecules and structures deep within tissues. Modern NIR FPs are engineered from bacterial phytochromes (photoreceptors that plants and some bacteria use to detect light) that are complexed with biliverdin (a breakdown product of heme, the hemoglobin subunit that gives blood its red color).... read more
Improving Ability to Diagnose Blood Cancers—The low blood counts that characterize the preleukemic disorder, myelodysplastic syndromes (MDS), occur because hematopoietic stem cells don’t fully differentiate into mature red cells but give rise to misshapen “dysplastic” cells. About 10 percent of MDS cases are caused by deletions in a region of chromosome 7 called 7q. In a study published in the November... read more
Progress against Acute Myeloid Leukemia—Einstein researchers led by Ulrich Steidl, M.D., Ph.D., demonstrated the potential of a new class of drugs for treating acute myeloid leukemia (AML), the most common form of acute leukemia in adults. AML and other cancers are caused by mutated forms of the protein isocitrate dehydrogenase 1 (IDH1). The new drugs inactivated IDH1 in AML cells... read more
Throughout the year, research papers and grants of note are highlighted on the Einstein website, in a section called “Research Round-up.” Explore the discoveries published in the last month.
Dr. Schramm is a member of the National Academy of Sciences and associate editor of the Journal of the American ...read more