Faculty Profile

Dr. Sanmay Bandyopadhyay, Ph.D.

Sanmay Bandyopadhyay, Ph.D.

Associate, Department of Pathology

Professional Interests

Areas of Research:

T cell tolerance and its epigenetic regulation; Chaperone-mediated autophagy and its role in the regulation of T cell activation; focused ultrasound as a means to complement immune- and radiotherapy to generate long-term protection after primary tumor ablation.


Professional Interests:

Our laboratory has had a long-standing interest in understanding the molecular mechanisms of initiation, establishment, and maintenance of peripheral T cell tolerance to self-antigens. Upon the delivery of tolerogenic signals in the periphery, T cells assume an alternative gene expression profile as opposed to what is observed in the case of encountering foreign antigens. Physiologically, continued presence of self-antigens renders the tolerized T cells refractory to antigenic stimuli, even when activated in vitro through TCR/Co-stimulatory receptor engagement. We investigate the roles of epigenetic modifications and marks that enable the T cells to be thus reprogrammed. In another research area, we investigate the roles of Chaperone-Mediated Autophagy (CMA) to optimally control T cell activation. We are exploring the mechanisms employed by CMA to selectively degrade specific target proteins that would counteract effective activation. Enabling the immune system to recognize tumor antigens and conferring long-term immune protection against cancers has been an intense field of study worldwide. A third focal area of our research is to develop focused ultrasound to be a combinatory aid in addition to more conventional radio- and immunotherapies to treat tumors. We have recently discovered that focused ultrasound in combination with ablative radiotherapy helps T cells reverse their tumor-induced tolerance, and provide long-term immune protection against metastatic melanoma.

Selected Publications


1. Bandyopadhyay S, Duré M, Paroder M, Soto-Nieves N, Puga I, Macián F. Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells. Blood. 2007 Apr 1;109(7):2878-86 PMCID:PMC1852212


2. Bandyopadhyay, S, Soto-Nieves N, Macián F. Transcriptional regulation of T cell tolerance. Semin Immunol. (2007)19(3):180-7. PMCID:PMC1978193


3. Soto-Nieves N, Puga I, Abe BT, Bandyopadhyay, S, Baine I, Rao A, Macian F. Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance. J Exp Med. (2009) Apr 13;206(4):867-76. PMCID:PMC2715123


4. Bandyopadhyay, S, Montagna C, Macian F. Silencing of the Il2 gene transcription is regulated by epigenetic changes in anergic T cells. Eur J Immunol. (2012) 42(9):2471-83. PMCID:PMC3681531


5. Bandyopadhyay, S, Valdor R, Macian F. Tle4 regulates epigenetic silencing of gamma interferon expression during effector T helper cell tolerance. Mol Cell Biol. (2014) 34(2):233-45. PMCID:PMC3911291


6. Bandyopadhyay S, Quinn TJ, Scandiuzzi L, Basu I, Partanen A, Tomé WA, Macian F, Guha C. Low-Intensity Focused Ultrasound Induces Reversal of Tumor-Induced T cell Tolerance and Prevents Immune Escape. Journal of Immunology (2016) 196(4):1964-76.







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Research Information