Indranil Basu, Ph.D.

Preclinical study involving the screening of chemopreventive & therapeutic efficacy and mechanism of action of orally available transition state analogue inhibitor of human methylthioadenosine phosphorylase (MTAP) as anti-cancer agent in cell culture and mouse xenografts of human head & neck, lung, prostate, breast, colon and cervical cancers by establishing the links between metabolite levels, biochemical changes, CpG island methylation and gene expression patterns of specific cell types.