Faculty Profile

Dr. Xiaonan (Nan) Xue, Ph.D.

Xiaonan (Nan) Xue, Ph.D.

Professor, Department of Epidemiology & Population Health

Director, Biostatistics Shared Resource, Albert Einstein Cancer Center

Professional Interests

Dr. Xue  received her BE from Tsinghua University, China; MS from University of Minnesota and PhD from The Johns Hopkins University.  Her research interest includes time to event analysis, longitudinal data analysis and application of statistical methods to epidemiological research in particular cancer research.  She has worked extensively  in the analysis of HPV data; methods for efficient cancer screening, and analytic approaches to study rare cancers.   Dr. Xue has also developed productive collaborations with epidemiologists, clinicians and basic scientists. Dr. Xue has become the Director of the Cancer Center Biostatistics Core since 2014.   Dr. Xue has also taught advanced statistics for many years in the Einstein Clinical Research Training Program. 

Selected Publications

Selected Publications

  1. Xue X.  Analysis of Childhood Brain Tumor Data in New York City Using Frailty Models.  Statistics in Medicine.  2001;20:3459-73.
  2. Kim MY, Xue X.  The analysis of multivariate interval-censored survival data.  Statistics in Medicine.  2002; 21, 3715-3726.
  3. Xue X and Shore ER. Methods for estimating occupational radiation doses subject to minimum detection levels. Health Physics, 2003; 84(1): 61-71.
  4. Xue X, Shore RE, Ye X. and Kim MY.  Estimating the dose response relationship for occupational radiation exposure measured with minimum detection level. Health Physics. 2004; 87(4): 397-404.
  5. Kim MY and Xue X. Likelihood ratio and a Bayesian approach were superior to standard noninferiority analysis when the noninferiority margin varied with the control event rate. Journal of Clinical Epidemiology. 2004; 57: 1253-1261. 
  6. Kim MY, Xue X and Du Y. Approaches for calculating power for case cohort studies. Biometrics. 2006; 62, 929-922. 
  7. Xue X, Kim MY and Shore RE. Estimation of health risks associated with occupational radiation exposure: addressing measurement error and minimum exposure level detectable. Health Physics. 2006. 91(6): 582-591.
  8. Xue X, Kim MY and Shore RE. Cox Regression Analysis in Presence of Collinearity: An application to Assessment of Health Risks Associated with Occupational Radiation Exposure. Lifetime Data Analysis 2007 13:133-350.  
  9. Harris TG, Burk RD, Xue X, Anastos K, Minkoff H, Massad LS, Young MA, Levine AM, Gange SJ, Watts DH, Palefsky JM, and Strickler HD. Association of cutaneous anergy with human papillomavirus and cervical neoplasia in HIV-seropositive and seronegative women. AIDS 2007, 21: 1933-1941.
  10. Ho GYF, Xue X, Cushman M, McKeown-Eyssen G, Sandler RS, Ahnen DJ, Barry EL, Saibil F, Robert S. Bresalier RS, Rohan TE, Baron JA. Antagonistic Effects of Aspirin and Folic Acid on Inflammation Markers and Subsequent Risk of Recurrent Colorectal Adenomas. JNCI 2009: 101-5.
  11. Heo M, Kim Y, Xue, X and Kim MY. Sample size requirement to detect an intervention effect at the end of follow-up in a longitudinal cluster randomized trial. Statistics in Medicine 29, 382-390. 2010.
  12. Xue X, Gange SJ, Zhong Y, et al. Marginal and Mixed Effects Models in the Analysis of HPV Natural History Data. Cancer Epidemiol Biomarkers Prev  2010;19(1):159-169.  
  13. Xie X, Xue X, Gange SJ, Strickler HD, Kim MY, Study Group WIHS. Estimation and inference on correlations between biomarkers with repeated measures and left-censoring due to minimum detection levels. Statistics in Medicine.  2012 Sep 20; 31(21):2275-89. 
  14. Keller MJ, Burk RD, Xie X, Anastos K, Massad LS, Minkoff H, Xue X, D'Souza G, Watts DH, Levine AM, Castle PE, Colie C, Palefsky JM, Strickler HDRisk of cervical precancer and cancer among HIV-infected women with normal cervical cytology and no evidence of oncogenic HPV infection. JAMA. 2012 Jul 25;308(4):362-9.
  15. Wang C, Xue X. Power and sample size calculations for evaluating mediation effects in longitudinal studies. Statistical methods in medical research. First published 2012, Dec 6.  0962280212465163.  
  16. Xue X,  Kim MY, Gaudet MM, Park Y, Heo M, Hollenbeck AR, Strickler HD, Gunter MJA comparison of the polytomous logistic regression and joint cox proportional hazards models for evaluating multiple disease subtypes in prospective cohort studies. Cancer epidemiology, biomarkers & prevention 2013;22(2):275-85.  
  17. Xie X, Strickler HD, Xue, X. Additive hazards regression models: an application to the natural history of human papillomavirus. Computational and Mathematical Methods in Medicine, 2013:796270. Epub 2013 Jan 28.  
  18. Xue X, Xie X, Gunter M, Rohan TE, Wassertheil-Smoller S, Ho GYF, Cirillo D, Yu H, Strickler HD. Testing the proportional hazards assumption in case-cohort analysis.   BMC Medical Research Methodology Jul 9; 13:88. 2013.  
  19. Barta SK, Xue X, Wang D, Tamari R, Lee JY, Mounier N, Kaplan LD, Ribera JM, Spina M, Tirelli U, Weiss R, Galicier L, Boue F, Wilson WH, Wyen C, Oriol A, Navarro JT, Dunleavy K, Little RF, Ratner L, Garcia O, Morgades M, Remick SC, Noy A, Sparano JA.Treatment factors affecting outcomes in HIV-associated non-Hodgkin lymphomas: a pooled analysis of 1,546 patients. Blood. 2013 Nov 7;122(19):3251-62.  
  20. Magnon C, Hall SJ, Lin J, Xue X, Gerber L, Freedland SJ, Frenette PS.Autonomic nerve development contributes to prostate cancer progression. Science. 2013 Jul 12;341(6142):1236361. doi: 10.1126/science. PMID: 23846904.
  21. Xue X, Kim MY, Castle PE, Strickler HD. A new method to address verification bias in studies of clinical screening tests: cervical cancer screening assays as an example. JCE 2014, (67) 343-353. PMID 24332397
  22. Heo M, Xue X, Kim MY. Sample size requirements to detect a two- or three-way interaction in longitudinal cluster randomized clinical trials with second-level randomization. Clinical Trials. 2014. May 16;11(4):503-507. 
  23. Rohan TE, Xue X, Lin HM, D’Afonso TM, Ginter PS, Oktay MH, Robinson BD, Ginsberg M, Gertler FB, Glass AG, Sparano JA, Condeelis JS, Jones JG (2014). Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer. JNCI, 2014; 106(8).   
  24. Xue X, Kim MY, Wang T, Kuniholm MH, Strickler HD. A statistical method for studying correlated rare events and their risk factors. Statistical Methods in Medical Research 2015. In press.
  25. Xue X, Xie X, Strickler HD. A censored quantile regression approach for the analysis of time to event data. Accepted by Statistical Methods in Medical Research. 2016.


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