Associate Professor, Dominick P. Purpura Department of Neuroscience
Associate Professor, Department of Genetics
Generating and regenerating the neocortex
The Hébert lab has two main focuses: first, understanding how a simple sheet of neuroepithelial cells early in embryogenesis develops into the adult neocortex, the part of our brains that we use for our highest cognitive and perceptual functions; and second, devising methods for regenerating the principle neurons of the adult neocortex when they are lost. For both interests, we use primarily molecular genetic techniques to manipulate the expression of regulatory genes in neural precursor cells in mice. More specifically, our two main goals are: 1) to understand how one class of genes, those that encode components of the FGF signaling pathway, regulate the behavior of neural precursor cells during development and in the adult forebrain; and 2) to establish paradigms for regenerating widely dispersed glutamatergic neurons in the adult neocortex using engineered neural precursor cells.
Gutin G, Fernandes M, Pallazolo L, Paek H, Kai Y, Ornitz D, McConnell SK, Hébert JM. (2006). FGF acts independently of SHH to generate ventral telencephalic cells. Development 133: 2937-2946.
Fernandes M, Gutin G, Alcorn H, McConnell SK, Hébert JM. (2007). Mutations in the BMP pathway in mice supports the existence of two molecular classes of holoprosencephaly. Development 134: 3789-3794.
Hanashima C, Fernandes M, Hébert JM, Fishell G. (2007). The role of Foxg1 and dorsal midline signaling in the generation of Cajal-Retzius subtypes. J. Neuroscience 27: 11103-11111.
Hébert JM, Fishell G. (2008). The genetics of telencephalon patterning, some assembly required. Nat. Rev. Neurosci., 9: 678-685.
Paek H, Gutin G, Hébert JM. (2009). FGF signaling is strictly required to maintain early telencephalic precursor cell survival. Development 136: 2457-2465.
Kang W, Wong LC, Shi S, Hébert JM. (2009). The transition from radial glial to intermediate progenitor cell is inhibited by FGF signaling during corticogenesis. J. Neuroscience 29: 14571-14580.
Paek H, Hwang JY, Zukin RS, Hébert JM. (2011). b-catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4. Developmental Cell 20: 689-699.
More Information About Dr. Jean Hebert
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Albert Einstein College of Medicine
Rose F. Kennedy Center
1410 Pelham Parkway South , Room 509
Bronx, NY 10461