Faculty Profile

Dr. Radhashree Maitra, Ph.D.

Radhashree Maitra, Ph.D.

Assistant Professor, Department of Medicine (Oncology)

Professional Interests

 

An attempt to search for cure of cancer has embarked on evaluating the therapeutic potential of bio-agents.  One such viable bio-particle is reovirus with an intrinsic preference to destroy oncogenic Kras activated transformed cell. More than 40% of human colorectal tumors are defective in K-Ras signaling cascade.  Presently my research aims in understanding the molecular mechanism of enhanced reovirus mediated cytotoxicity  in Kras compromised cellular environment. The insight has been further implemented in evaluating the therapeutic efficacy of reovirus in combination with chemotherapeutic drugs. This study is important especially for the group of patients with platinum refractory Kras mutated metastatic colorectal cancer (mCRC) where no FDA approved alternative therapy available.

Selected Publications

1. Augustine T. A, Baig M, Sood A, Budagov T, Atzmon G, Mariadason J.M, Aparo S, Maitra R, Goel S. Telomere length is a novel predictive biomarker of sensitivity to anti-EGFR therapy in metastatic colorectal cancer. 2014 British J  Cancer. 2015 Jan 20;112(2):313-8. doi: 10.1038/bjc.2014.561

2.Maitra R, Seetharam R, Tesfa L, Augustine, T.A, Klampfer, A, Coffey M.C, Mariadason J.M , and Goel S. Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan. (2014) Oncotarget. May 15;5(9):2807-19. PMID: 24798549

3. Maitra R, Nayak J.B, Merla A, Sood A, Augustine T.A, Baig M, Reynolds D.M, Mariadason J.M, Aparo S, and Goel S. A Single Nucleotide Polymorphism in the MGMT gene is a novel prognostic biomarker in patients with metastatic colorectal cancer. British Journal of medicine and medical Research. 2014/BJMMR/12841 published online DOI:10.9734/BJMMR/2014/12841

4. Maitra R, Ghalib MH, Goel S, REOVIRUS: A Targeted Therapeutic- Progress and Potential. Mol Cancer Res. 2012 (AACR Journal) Dec;10(12):1514-25. doi: 10.1158/1541-7786.MCR-12-0157

5.Sood A, McClain D, Maitra R, Basu-Mallick A, Seetharam R, Kaubisch A, Rajdev L, Mariadason JM, Tanaka K, Goel S. PTEN Gene Expression and Mutations in the PIK3CA Gene as Predictors of Clinical Benefit to Anti-Epidermal Growth Factor Receptor Antibody Therapy in Patients With KRAS Wild-Type Metastatic Colorectal Cancer. Clin Colorectal Cancer. 2012 Jun;11(2):143-50. doi: 10.1016/j.clcc.2011.12.001

6. Maitra R, Follenzi A, Yaghoobian A, Montagna C, Merlin S, Cannizzo ES, Hardin JA, Cobelli N, Stanley ER, Santambrogio L. Dendritic cell-mediated in vivo bone resorption.  J Immunol. 2010 Aug 1;185(3):1485-91.  doi: 10.4049/jimmunol.0903560

7. Cristina Corina Clement, Radhashree Maitra, Ranjit Sahu, and Laura Santambrogio. Self –peptidomic repertoire of the human pre-nodal lymph  FASEB J. 2009 23:857.

8. Bunbury, A., Potolicchio, I., Maitra, R., Santambrogio L. Functional analysis of monocyte MHC class II compartments.FASEB J.  2009 Jan;23(1):164-71  doi: 10.1096/fj.08-109439

9. Maitra, R., Sadofsky, M.J., A WW-like module in RAG1 N-terminal domain contributes to previously unidentified protein-protein interactions. Nucleic Acids Res. 2009 Jun;37(10):3301-9. doi: 10.1093/nar/gkp192

10. Maitra R, Clement CC, Scharf B, Crisi GM, Chitta S, Paget D, Purdue PE, Cobelli N, Santambrogio L. Endosomal damage and TLR2 mediated inflammasome activation by alkane particles in the generation of aseptic osteolysis. Mol Immunol. 2009 Dec;47(2-3):175-84. doi: 10.1016/j.molimm.2009.09.023

11. Maitra, R., Clement, C.C., Crisi, G.M., Cobelli, N., Santambrogio L. Immunogenecity of modified alkane polymers is mediated through TLR1/2 activation.PLoS ONE. 2008 Jun 18;3 (6):e2438 doi:10.1371/journal.pone.0002438.

12. Santambrogio, L., Maitra, R., Xie, L., Wang, X., Cobelli, N. J., . Hardin, J.A., Dendritic cells responses to polyethylene particle: Potential triggers for aseptic osteolysis. Osteoarthritis and Cartilage . 01/2007; 15. DOI:10.1016/S1063-4584(07) 1771-3

13.Inagaki, N.,Maitra, R.,Satoh, K., Pakrasi, H.B.  Amino acid residues that are critical for in vivo catalytic  activity of  CtpA,  the  carboxyl-terminal  processing  protease  for  the D1 protein of photosystem II. J Biol Chem, 2001,  276,  30099-105. PMID: 11408480

14. Zak, E.A.., Norling, B.,  Maitra, R., Huang F., Anderson, B., Pakrasi, H.B. The initial steps of biogenesis of cyanobacterial photosystems occur in plasma membranes. Proc Natl Acad Sci U S A. 200198,  13443-8. PMID: 11687660

15. Maitra, R., Thakur, A.R. Hydroxyl  radical  induced  DNA  damage:  choice  of  an  in vitro   model. International Journal of Toxicology, Occupational and Environmental   Health.1993, 56,  6-9.

16. Maitra, R., Thakur, A.R.  Multiple  fragment   ligation  on  glass   surface: A novel  approach. Indian Journal of Biochemistry and Biophysics, 1993,  31,  97-99. PMID: 7927440

17. Maitra, R., Thakur, A.R. Silanisation  of glass bound baked DNA permits enhanced polymerization by DNA polymerase. Current Science 1992, 62, 586-588

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Research Information