Professor, Department of Anatomy & Structural Biology
Macrophages play an important role in host defense against invading micro-organisms and they are also key players in initiating and maintaining an immune response. However, macrophages can also play negative roles, such as in chronic inflammatory diseases. Also, tumor-associated macrophages (TAMs), which are present in large numbers in many tumors, appear to play an important role in promoting the progression of solid tumors to an invasive, metastatic phenotype. Macrophages are therefore a prime target for therapies, but it is important to elucidate the mechanisms by which they are recruited to and activated in tissues.
1. Abou-Kheir, W.G., Isaac, B., Yamaguchi H., and Cox, D. (2008) Membrane targeting of WAVE2 is not sufficient for WAVE2 dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2. J. Cell Sci. 121:379-90. PMCID:PMC2749557
2. Hernandez-Tellez, Smirnova, T., Kedrin, D., L., Wyckoff, J., Stanley, E.R., Cox, D., Muller, W.J., Pollard, J.W., Van Rooijen, N., and J. Segall. (2009) EGF/CSF1Induced Breast Cancer Cell Invasion is Triggered by Heregulin Beta 1 and CXCL12. Cancer Research 69:3221-3227. PMCID:PMC2820720
3. Ojalvo, L.S., King, W., Cox, D., and J.W. Pollard (2009) High Density Gene Expression Analysis of Tumor Associated Macrophages from Mouse Mammary Tumors. Amer. J. Path. 174:1048-1064. PMCID:PMC2665764
4. Cammer, M., Gevrey, J-C., Lorenz, M., Dovas, A., Condeelis, J. and Cox, D. (2009) The mechanism of CSF-1 induced WASp activation in vivo: A role of PI 3-kinase and Cdc42. J. Biol. Chem. 284:23302-11. PMCID:PMC2749104
5. Luo, Y., Isaac, B.M., Casadevall, A., and Cox D. (2009) Macrophage phagocytosis suppresses F-actin enriched membrane protrusions stimulated by CX3CL1 and CSF-1. Infect. and Immun. 77:4487-4495. PMCID:PMC2747920
6. Park, H. and Cox, D. (2009) Cdc42 regulated Fcγ receptor mediated phagocytosis through activation and phosphorylation of WASP and N-WASP. Molec. Biol. Cell 20:4500-8. PMCID:PMC2770938
7. Dovas, A., Gevrey, J-C., Grossi, A., Park, H., Abou-Kheir, W.A., and Cox, D. (2009) Regulation of podosome dynamics by Wiskott-Aldrich Syndrome protein (WASp) phosphorylation: implication in matrix degradation and chemotaxis in macrophages. J. Cell Sci. 122:3873-82. PMCID:PMC2773189
8. Isaac, B.M.*, Ishihara, D.*, Nusblat, L.M., Gevrey, J-C, Dovas A., Condeelis, J., and Cox, D. (2010) N-WASP has the Ability to Compensate for the Loss of WASP in Macrophage Podosome Formation and Function. Exp. Cell Res. 316:3406-3416. PMCID: PMC2976787 * equal contribution.
9.Nusblat, L.M., Dovas, A., and Cox. D. (2011). The non-redundant role of N-WASP in podosome-mediated matrix degradation in macrophages. Eur. J. Cell Biol. 90:205-212. PMCID: PMC3012153
10. Oser, M., Dovas, A., Cox, D., and Condeelis, J. (2011) Nck1 and Grb2 localization patterns can distinguish invadopodia from podosomes. Eur. J. Cell Biol. 90:181-188. PMCID: PMC3017226
11. Park, H. and Cox, D. (2011) Syk regulates multiple signaling pathways leading to CX3CL1 chemotaxis in macrophages. J. Biol. Chem. 286:14762-9. PMCID: PMC3083178
12. Dovas, A., Gligorijevic, B., Chen, X., Entenberg, D., Condeelis, J. and Cox, D. (2011) Visualisation of actin dynamics in invasive structures of macrophages and carcinoma cells using photoconvertible b-actin – Dendra2 fusion proteins. PLoS One 6:e16485. PMCID: PMC3038862
13. Dovas, A. and Cox, D. (2011) Signaling networks regulating leukocyte podosome dynamics and function. Cell Signal.23:1225-34. PMCID: PMC3095719
14. Park, H., Dovas, A. and Cox, D. (2011) N-WASP. In Encyclopedia of Signaling Molecules. Ed. by S. Choi (Springer).
15. Ishihara, D., Dovas A., Isaac, B.M., and Cox, D. (2012) The Chemotactic defect in Wiskott-Aldrich Syndrome macrophages is due to reduced persistence of directional protrusions. PLoS One 7(1):e30033 PMCID:PMC3261183.
16. Sharma, V., Patsialou, A., Beaty, B.T., Liu, H., Clarke, M., Cox, D., Condeelis, J. and Eddy, R. (2012) Reconstitution of in vivo macrophage-tumor cell pairing and streaming motility on one-dimensional micro-patterned substrates. IntraVital In press.
17. Dovas. A., Patsialou, A., Harney, A.S., Condeelis, J. and Cox, D. (2012) Imaging interactions between macrophages and tumor cells that are involved in metastasis in vivo. J. Microscopy In press
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More Information About Dr. Dianne Cox
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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
MRRC, Room 306A
Bronx, NY 10461