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Faculty Profile

Michael V. L. Bennett, D.Phil.

Dr. Michael V. L. Bennett

Distinguished Professor, Dominick P. Purpura Department of Neuroscience

Sylvia and Robert S. Olnick Chair in Neuroscience

 

Selected Publications

Electrical synapses, gap junctions and hemichannels

Garre, J.M., Bennett, M.V.L. Gap junctions and electrical synapses. In: The Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance, Eds: Hortsch, M.; Umemori, H.; Springer, 2009, pp. 423 ¨C 440. 332.

Orellana, J.A., Hern¨¢ndez, D.E., Ezan, P., Velarde, V., Bennett, M.V.L., Giaume, C., S¨¢ez, J.C. Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels. Glia, 58: 329 ¨C 343, 2010.

Bennett, M.V.L. Gap junctions and electrical synapses. In: Squire LR (ed.) Encyclopedia of Neuroscience, vol. 4, pp. 529-548, Oxford, Academic Press, 2009.

Orellana, J.A., S¨¢ez, P.J., Shoji, K.F., Schalper, K.A., Palacios-Prado, N., Velarde, V., Giaume, C., Bennett, M.V.L., S¨¢ez, J.C. Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration. Antioxidants & Redox Signaling, 11: 369-399, 2009.

Flores, C.E., Li, X., Bennett, M.V.L., Nagy, J.I., Pereda, A.E. Interaction between connexin35 and zonula occludens-1 and its potential role in the regulation of electrical synapses. Proc. Natl. Acad. Sci. USA, 105: 12545-1250, 2008.

Retamal, M.A., Schalper, K.A., Shoji, K.F., Bennett, M.V.L., S¨¢ez, J.C. Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential. Proc. Natl. Acad. Sci. USA, 104: 8322-8327, 2007.

Retamal, M.A., Schalper, K.A., Shoji, K.F., Orellana, J.A., Bennett, M.V.L., Saez, J.C. Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion. J. Membr. Biol., 218: 49-63, 2007.

Bennett, M.V.L., Pereda, A. Pyramid power: Principal cells of the hippocampus unite! Brain Cell Biololgy, 35: 5-11, 2006.

Abrams, C.K., Freidin, M.M., Verselis, V.K., Bargiello, T.A., Kelsell, D.P., Richard, G., Bennett, M.V.L., Bukauskas, F.F. Properties of human connexin 31, which is implicated in hereditary dermatological disease and deafness. Proc. Natl. Acad. Sci. USA, 103: 5213-5218, 2006.

Bukauskas, F.F., Kreuzberg, M.M., Rackauskas, M., Bukauskiene, A., Bennett, M.V.L., Verselis, V.K., Willecke, K. Properties of mouse connexin 30.2 and human connexin 31.9 hemichannels: Implications for atrioventricular conduction in the heart. Proc. Natl. Acad. Sci. USA, 103: 9726-9731, 2006.

NMDA receptors

Lau, C.G., Takayasu, Y., Rodenas-Ruano, A., Paternain, A.V., Lerma, J., Bennett, M.V.L., Zukin, R.S. SNAP-25 is a target of PKC phosphorylation critical to NMDA receptor trafficking. J. Neurosci. 30: 242-254, 2009.

Lau, C.G., Takeuchi, K., Rodenas-Ruano, A., Takayasu, Y., Murphy, J., Bennett, M.V.L., Zukin, R.S. Regulation of NMDA receptor Ca2+ signalling and synaptic plasticity. Biochem. Soc. Trans. 37: 1369 - 74, 2009.

Yang, Y., Takeuchi, K., Rodenas-Ruano, A., Takayasu, Y., Bennett, M.V.L., Zukin, R.S. Developmental switch in
requirement for PKA RIIbeta in NMDA-receptor-dependent synaptic plasticity at Schaffer collateral to CA1 pyramidal cell synapses. Neuropharmacology, 56: 56-65, 2009.

Skeberdis, V.A., Chevaleyre, V., Lau, C.G., Goldberg, J.H., Pettit, D.L., Suadicani, S.O., Lin, Y., Bennett, M.V.L., Yuste, R., Castillo, P.E., Zukin, R.S. Protein kinase A regulates calcium permeability of NMDA receptors. Nat. Neurosci. 9: 501-510, 2006.

Lin, Y., Jover-Mengual, T., Wong, J., Bennett, M.V.L., Zukin, R.S. PSD-95 and PKC converge in regulating NMDA receptor trafficking and gating. Proc. Natl. Acad. Sci. USA, 103: 19902-19907, 2006.

Global ischemia, delayed neurodegeneration

Stetler, R.A., Gao, Y., Zukin, R.S., Vosler, P.S., Zhang, L., Zhang, F., Cao, G., Bennett, M.V.L., Chen, J. Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia. Proc. Natl. Acad. Sci. USA. 107: 3204 - 9, 2010.

Miyawaki, T., Mashiko, T., Ofengeim, D., Flannery, R.J., Noh, K.-M., Bonanni, L., Bennett, M.V.L., Zukin, R.S., Jonas, E.A. Ischemic preconditioning blocks mitochondrial translocation of BAD and cleavage of Bcl-xL in CA1 neurons after severe ischemic insult. Proc. Natl. Acad. Sci. USA, 105: 4892-4897, 2008.

Formisano, L., Noh, K.M., Miyawaki, T., Mashiko, T., Bennett, M.V.L., Zukin, R.S. Ischemic insults promote epigenetic reprogramming of ¦Ì opioid receptors in hippocampal neurons. Proc. Natl. Acad. Sci. USA, 104: 4170-4175, 2007.

 

More Information About Dr. Michael Bennett

Einstein Faculty Profile

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Contact

Albert Einstein College of Medicine
Rose F. Kennedy Center
1410 Pelham Parkway South , Room 704
Bronx, NY 10461

Tel: 718.430.2536
michael.bennett@einstein.yu.edu

 
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