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Faculty Profile

Jeffrey E. Segall, Ph.D.

Dr. Jeffrey E. Segall

Professor, Department of Anatomy & Structural Biology

Professor, Department of Pathology

Betty and Sheldon Feinberg Senior Faculty Scholar in Cancer Research

 

Professional Interests

For most cancers, the cause of patient death is either local invasion into critical areas or metastasis - dissemination of tumor cells from the primary tumor to many parts of the body followed by formation of new tumors at those distant sites. By understanding the mechanisms by which tumor cells invade and metastasize, we will have better chances of developing appropriate therapies. Tumor cell motility and the orientation of tumor cells by chemotaxis make important contributions to invasion and metastasis.  Three types of cancer are being studied.  Glioblastoma and head and neck cancer invade locally into critical areas and the primary tumors are not fully removable by surgery.  Breast cancer, although the primary tumor can be fully removed, metastasizes to distant sites, and the resulting metastases can lead to poor prognosis.  Tissue culture studies of invasion and signaling of these cancers are combined with in vivo analysis in mice. 

 

Selected Publications

1: Entenberg D, Kedrin D, Wyckoff J, Sahai E, Condeelis J, Segall JE. Imaging tumor cell movement in vivo. Curr Protoc Cell Biol. 2013 Mar;Chapter 19:Unit19.7. doi: 10.1002/0471143030.cb1907s58. PubMed PMID: 23456602; PubMed Central PMCID: PMC3722061.

 2: Friedl P, Locker J, Sahai E, Segall JE. Classifying collective cancer cell invasion. Nat Cell Biol. 2012 Aug;14(8):777-83. doi: 10.1038/ncb2548. Review. PubMed PMID: 22854810.

 3: Coniglio SJ, Eugenin E, Dobrenis K, Stanley ER, West BL, Symons MH, Segall JE. Microglial stimulation of glioblastoma invasion involves epidermal growth factor  receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling. Mol  Med. 2012 May 9;18:519-27. doi: 10.2119/molmed.2011.00217. PubMed PMID: 22294205; PubMed Central PMCID: PMC3356419.

 4: Childs G, Segall JE. Twists and turns of invasion. Nat Cell Biol. 2012 Apr 2;14(4):337-9. doi: 10.1038/ncb2477. PubMed PMID: 22469829.

 5: Harris T, Jimenez L, Kawachi N, Fan JB, Chen J, Belbin T, Ramnauth A, Loudig O, Keller CE, Smith R, Prystowsky MB, Schlecht NF, Segall JE, Childs G. Low-level expression of miR-375 correlates with poor outcome and metastasis while altering  the invasive properties of head and neck squamous cell carcinomas. Am J Pathol. 2012 Mar;180(3):917-28. doi: 10.1016/j.ajpath.2011.12.004. Epub 2012 Jan 9. PubMed PMID: 22234174; PubMed Central PMCID: PMC3349885.

 6: Smirnova T, Zhou ZN, Flinn RJ, Wyckoff J, Boimel PJ, Pozzuto M, Coniglio SJ, Backer JM, Bresnick AR, Condeelis JS, Hynes NE, Segall JE. Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis. Oncogene. 2012 Feb 9;31(6):706-15. doi: 10.1038/onc.2011.275. Epub 2011 Jul 4. PubMed PMID: 21725367; PubMed Central PMCID: PMC3469325.

 7: Boimel PJ, Smirnova T, Zhou ZN, Wyckoff J, Park H, Coniglio SJ, Qian BZ, Stanley ER, Cox D, Pollard JW, Muller WJ, Condeelis J, Segall JE. Contribution of CXCL12 secretion to invasion of breast cancer cells. Breast Cancer Res. 2012 Feb  7;14(1):R23. PubMed PMID: 22314082; PubMed Central PMCID: PMC3496141.

 8: Hulit J, Kedrin D, Gligorijevic B, Entenberg D, Wyckoff J, Condeelis J, Segall JE. The use of fluorescent proteins for intravital imaging of cancer cell invasion. Methods Mol Biol. 2012;872:15-30. doi: 10.1007/978-1-61779-797-2_2. PubMed PMID: 22700401.

 9: Kim RS, Avivar-Valderas A, Estrada Y, Bragado P, Sosa MS, Aguirre-Ghiso JA, Segall JE. Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer. PLoS One. 2012;7(4):e35569. doi: 10.1371/journal.pone.0035569. Epub 2012 Apr 18. PubMed PMID: 22530051; PubMed Central PMCID: PMC3329481.

 10: Loudig O, Brandwein-Gensler M, Kim RS, Lin J, Isayeva T, Liu C, Segall JE, Kenny PA, Prystowsky MB. Illumina whole-genome complementary DNA-mediated annealing, selection, extension and ligation platform: assessing its performance  in formalin-fixed, paraffin-embedded samples and identifying invasion pattern-related genes in oral squamous cell carcinoma. Hum Pathol. 2011 Dec;42(12):1911-22. doi: 10.1016/j.humpath.2011.02.011. Epub 2011 Jun 17. PubMed  PMID: 21683979.

 11: Zhou ZN, Boimel PJ, Segall JE. Tumor-stroma: In vivo assays and intravital imaging to study cell migration and metastasis. Drug Discov Today Dis Models. 2011 Fall;8(2-3):95-112. PubMed PMID: 22081771; PubMed Central PMCID: PMC3212048.

 12: Boimel PJ, Cruz C, Segall JE. A functional in vivo screen for regulators of tumor progression identifies HOXB2 as a regulator of tumor growth in breast cancer. Genomics. 2011 Sep;98(3):164-72. doi: 10.1016/j.ygeno.2011.05.011. Epub 2011 Jun 13. PubMed PMID: 21672623; PubMed Central PMCID: PMC3165059.

 13: Smirnova T, Adomako A, Locker J, Van Rooijen N, Prystowsky MB, Segall JE. In  vivo invasion of head and neck squamous cell carcinoma cells does not require macrophages. Am J Pathol. 2011 Jun;178(6):2857-65. doi: 10.1016/j.ajpath.2011.02.030. PubMed PMID: 21641405; PubMed Central PMCID: PMC3124357.

 14: Locker J, Segall JE. Breast cancer: the matrix is the message. Am J Pathol. 2011 Mar;178(3):966-8. doi: 10.1016/j.ajpath.2010.12.013. PubMed PMID: 21356348;  PubMed Central PMCID: PMC3069911.

 15: Hernandez L, Magalhaes MA, Coniglio SJ, Condeelis JS, Segall JE. Opposing roles of CXCR4 and CXCR7 in breast cancer metastasis. Breast Cancer Res. 2011;13(6):R128. doi: 10.1186/bcr3074. Epub 2011 Dec 9. PubMed PMID: 22152016; PubMed Central PMCID: PMC3326570.

 16: Piatkevich KD, Hulit J, Subach OM, Wu B, Abdulla A, Segall JE, Verkhusha VV.  Monomeric red fluorescent proteins with a large Stokes shift. Proc Natl Acad Sci  U S A. 2010 Mar 23;107(12):5369-74. doi: 10.1073/pnas.0914365107. Epub 2010 Mar 8. PubMed PMID: 20212155; PubMed Central PMCID: PMC2851791.

 17: Kedrin D, Wyckoff J, Boimel PJ, Coniglio SJ, Hynes NE, Arteaga CL, Segall JE. ERBB1 and ERBB2 have distinct functions in tumor cell invasion and intravasation. Clin Cancer Res. 2009 Jun 1;15(11):3733-9. doi: 10.1158/1078-0432.CCR-08-2163. Epub 2009 May 19. PubMed PMID: 19458057; PubMed Central PMCID: PMC2859965.

 18: Hernandez L, Smirnova T, Kedrin D, Wyckoff J, Zhu L, Stanley ER, Cox D, Muller WJ, Pollard JW, Van Rooijen N, Segall JE. The EGF/CSF-1 paracrine invasion loop can be triggered by heregulin beta1 and CXCL12. Cancer Res. 2009 Apr 1;69(7):3221-7. doi: 10.1158/0008-5472.CAN-08-2871. Epub 2009 Mar 17. PubMed PMID: 19293185; PubMed Central PMCID: PMC2820720.

 19: Symons M, Segall JE. Rac and Rho driving tumor invasion: who's at the wheel?  Genome Biol. 2009;10(3):213. doi: 10.1186/gb-2009-10-3-213. Epub 2009 Mar 6. Review. PubMed PMID: 19291272; PubMed Central PMCID: PMC2690992.

 20: Hernandez L, Smirnova T, Wyckoff J, Condeelis J, Segall JE. In vivo assay for tumor cell invasion. Methods Mol Biol. 2009;571:227-38. doi: 10.1007/978-1-60761-198-1_15. PubMed PMID: 19763970; PubMed Central PMCID: PMC3156574.

 

 

 

More Information About Dr. Jeffrey Segall

Segall Lab Website

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Contact

Albert Einstein College of Medicine
Michael F. Price Center
1301 Morris Park Avenue , Room 201
Bronx, NY 10461

Tel: 718.678.1109
Fax: 718.678.1019
jeffrey.segall@einstein.yu.edu

 
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Media Coverage

Reuters interviews Dr. Jeffrey Segall, professor of anatomy and structural biology, on a novel method of viewing cancer cells over several days. The article, entitled "Glass implant on tumor helps track cancer in mice," is based on a study published by Nature Methods under the direction of Dr. Segall and John Condeelis, Ph.D., co-chair and professor of anatomy and structural biology and co-director of the Gruss Lipper Biophotonics Center.

More media coverage