The soil nematode Caenorhabdidis elegans is a model system used to study the genetic control of cellular development. Our laboratory specializes in ultrastructural studies of the nervous system. We use serial thin sections, electron microscopy, electron tomography, and immunocytochemistry as primary tools to follow the development of identified neurons, particularly their axon outgrowth and synaptic connectivity. We also conduct collaborative studies on many other tissues in the embryo, larval, adult and aging nematode.
We host the Center for C. elegans Anatomy, supported by the NIH Division of Research Resources, and train students in anatomical methods for this system. Members of the lab are authoring the website www.WormAtlas.org. It displays nematode anatomy in great detail through multiple applications including Slideable Worm, a Handbook of all cells and tissues, a Glossary, and selected html texts of classic papers.
Wired Worm is a project aiming to complete the wiring diagram for the male adult nematode, working with Scott Emmons (Mol. Genetics, AECOM).
Neumann, B., Nguyen, K.C.Q., Hall, D.H., Ben-Yakar, A. and Hilliard, M.A. (2011) Axonal regeneration
proceeds through axonal fusion in C. elegans neurons. Dev. Dynamics, in press.
Hall, D.H., Hartwieg, E. and Nguyen, K.C. Q. (2011) Modern electron microscopy methods for C. elegans.
In Methods in Cell Biology (Ed) Joel Rothman. Academic Press, New York, in press.
Albeg, A., Smith, C., Chatzigeorgiou, M., Feitelson, D.G., Hall, D.H., Schaefer, W.R., Miller, D.M. III,
and Treinin, M. (2011) C. elegans multi-dendritic sensory neurons: morphology and function.
Mol. Cell. Neurosci 46:308-17.
Oren-Suissa, M., Hall, D.H., Treinin, M., Shemer, G., and Podbilewicz, B. (2010) The fusogen
EFF-1 controls sculpting of mechanosensory dendrites. Science 328: 1285-8.
Altun, Z.F., Chen, B., Thomas, J.H., Wang, Z-W. and Hall, D.H. (2009) A high-resolution map of C. elegans
gap junction proteins. Dev. Dynamics 238: 1936-1950.
Zhou, K., Rolls, M.M., Hall, D.H., Malone, C.J. and Hanna-Rose, W. (2009) A ZYG-12-dynein interaction at the
nuclear envelope defines cytoskeletal architecture in the C. elegans gonad. J. Cell Biol. 186: 229-241.
Wang, J., Farr, G.W., Hall, D.H., Furtak, K., Dreier, L. and Horwich, A.L. (2009) An ALS-linked mutant
SOD1 produces a locomotor defect associated with aggregate formation and synaptic dysfunction when
expressed in neurons of Caenorhabditis elegans. PLoS Genetics Jan;5(1):e1000350. Epub 2009 Jan 23.
Stone, C.E., Hall, D.H. and Sundaram, M.V. (2009) Lipocalin signaling controls unicellular tube development
in Caenorhabditis elegans. Developmental Biol. 329: 201-211.
Hall, D.H. and Altun, Z. (2008) C. elegans Atlas. Cold Spring Harbor Laboratory Press, 340 pp.
Jauregui, A.R., Nguyen, K.C.Q., Hall, D.H. and Barr, M.M. (2008) C. elegans nephrocystin-1 and
nephrocystin-4 modulate cilia development and morphogenesis. J Cell Biol.180: 973-88.
Ciche, T.A., Kim, K-s., Kaufman-Daszczuk, B., Nguyen, K.C.Q. and Hall, D.H. (2008) Cell invasion and
matricide during symbiont transmission in nematodes. Appl Env Microbiol. 74: 2275-87.
Marza, E., Long, T., Saiardi, A., Eimer, S., Hall, D.H. and Lesa, G. M. (2008) Polyunsaturated fatty acids
influence synaptojanin localization to regulate synaptic vesicle recycling. Mol Biol of the Cell 19: 833-42.
B�nard, C.Y., Boyanov, A., Hall, D.H. and Hobert, O. (2006) DIG-1, a novel giant protein non-autonomously
mediates maintenance of nervous system architecture. Development 133: 3329-40.
Rowland, A.M., Olsen, J.G., Richmond, J.E., Hall, D.H. and Bamber, B.A. (2006) Presynaptic terminals
independently regulate synaptic clustering and autophagy of GABAA receptors in Caenorhabditis
elegans. J. Neuroscience 26: 1711-20.
Chen, B., Hall, D.H. and Chklovskii, D.B. (2006) Wiring optimization can relate neuronal structure
and function. PNAS 103: 4723-4728.
Kao, G., Huang, C-c., Hedgecock, E.M., Hall, D.H. and Wadsworth, W. (2006) Role of the laminin b subunit
in C. elegans basement membrane function and development. Dev. Biol. 290: 211-219.
Shemer, G., Suissa, M., Kolotuev, I., Nguyen, K.C.Q., Hall, D.H., and Podbilewicz, B. (2004) EFF-1 is
sufficient to initiate and execute tissue-specific cell fusion in C. elegans. Current Biology 14: 1587-91.
Berry, K., Bulow, H.E., Hall, D.H. and Hobert, O. (2003) Intracellular tube formation requires a C. elegans CLIC ion channel homolog. Science 302: 2134-37.
Melendez, A., Talloczy, Z., Seaman, M., Eskelinen, E-L., Hall, D.H., and Levine, B. (2003) Autophagy genes are essential for dauer development and lifespan extension in C. elegans. Science 301: 1387-91.
Huang, C-c., Hall, D.H., Hedgecock, E.M., Kao, G., Karantza, V., Vogel, B., Hutter, H., Chisholm, A.D.,Yurchenco, P.D., and Wadsworth, W.G. (2003) Laminin a subunits and their role in C. elegans development. Development 130: 3343-3358.
Herndon, L.A., Schmeissner, P.J., Dudaroneck, J.M., Brown, P.A., Listner, K.M., Paupard, M.C., Hall, D.H., and Driscoll, M. (2002) Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419: 788-794.
Aurelio, O, Hall, DH, and Hobert, O (2002) Immunoglobulin-domain proteins required for maintenance of ventral nerve cord organization. Science 295: 686-690.
Nass, R., Hall, D.H., Miller, D.M. and Blakeley, R.D. (2002) Neurotoxin-induced degeneration of dopamine neurons in C. elegans. PNAS 99: 3264-3269.
More Information About Dr. David Hall
Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.
Albert Einstein College of Medicine
Rose F. Kennedy Center
1410 Pelham Parkway South
, Room 601
Bronx, NY 10461
Tel: 718.430.2195
Fax: 718.430.2514
david.hall@einstein.yu.edu