Faculty Profile

Dr. David H. Hall, Ph.D.

David H. Hall, Ph.D.

Professor, Dominick P. Purpura Department of Neuroscience

Areas of Research: Connectomics, ciliogenesis, genetic control of axon guidance, axonal transport, and neuronal cell fate in Caenorhabditis elegans, tubulogenesis in nematode epithelia, anatomy of aging in nematode tissues, new methods in EM

Professional Interests

The soil nematode Caenorhabdidis elegans is a model system used to study the genetic control of cellular development.  Our laboratory specializes in ultrastructural studies of the nervous system.  We use serial thin sections, electron microscopy, electron tomography, and immunocytochemistry as primary tools to follow the development of identified neurons, particularly their axon outgrowth and synaptic connectivity.  We also conduct collaborative studies on many other tissues in the embryo, larval, adult and aging nematode.


We host the Center for C. elegans Anatomy, supported by the Office of the Director of NIH, and train students in anatomical methods for this system.  Members of the lab are authoring the website www.WormAtlas.org.  It displays nematode anatomy in great detail through multiple applications including Slideable Worm, and Handbooks of all cells and tissues in the Hermaphrodite, the adult Male, and the Dauer Larva.  We also author a second website, www.WormImage.org, which offers a photo catalogue for thousands of archival EM images of nematode tissues in all stages and in many behavioral mutants


Wired Worm is a project aiming to complete the wiring diagram for the male adult nematode and the L1 larval nematode, working with Scott Emmons (Mol. Genetics, AECOM). Progress on those projects is displayed at a third website, www.WormWiring.org.


Selected Publications


Warburton-Pitt, S.R., Silva, M., Nguyen, K.C., Hall, D.H. and Barr, M.M. (2014) The nphp-2 and arl-13 genetic modules interact to regulate  ciliogenesis and ciliary microtubule patterning in C. elegans. PLoS Genet. 10(12)e1004866. Doi: 10.1371/journal.pgen.1004866. 

Morrissey, M.A., Keeley, D.P., Hagedorn, E.J., McClatchey, S.T., Chi, Q., Hall, D.H. and Sherwood, D.R.  (2014) B-LINK: a hemicentin, plakin, and integrin-dependent adhesion system that links tissues by connecting adjacent basement membranes. Dev. Cell 31: 319-31. 

Starich, T.A., Hall, D.H. and Greenstein, D. (2014) Two classes of gap junction channels mediate soma germline interactions essential for germline proliferation and gametogenesis in C. elegans. Genetics 198: 1127-53 

Nguyen, P.A.T., Liou, W., Hall, D.H. and Leroux, M.R. (2014) Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron. J. Cell Science 127:5317-30. 

Wang, J., Silva M., Haas, L.A., Nguyen, K.C.Q., Hall, D.H. and Barr, M.M. (2014) C. elegans ciliated sensory neurons release extracellular vesicles that function in animal communication. Curr. Biol. 24: 519-25 

Riddle M.R., Weintraub A., Nguyen K.C., Hall D.H., Rothman J.H. (2013) Transdifferentiation and remodeling of postembryonic C. elegans cells by a single transcription factor. Development. Dec;140(24):4844-9. 

Zhang J, Li X, Jevince AR, Guan L, Wang J, Hall DH, Huang X, Ding M. (2013) Neuronal target identification requires AHA-1-mediated fine-tuning of Wnt signaling in C. elegans. PLoS Genet. Jun;9(6):e1003618.

Khan LA, Zhang H, Abraham N, Sun L, Fleming JT, Buechner M, Hall DH, Gobel V. (2013) Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux. Nat Cell Biol. Feb;15(2):143-56.

Jarrell, T.A., Wang, Y., Bloniarz, A.E., Brittin, C.A., Xu, M., Thomson, J.N., Albertson, D.G., Hall, D.H. and Emmons, S.W. (2012)  The connectome of a decision making neuronal network. Science 337: 437-444.

Topalidou, I, Keller, C., Kalebic, N., Nguyen, K.C., Somhegyi, H., Politi, K.A., Heppenstall, P., Hall, D.H. and Chalfie, M. (2012) Both enzymatic and structural activities of the tubulin acetyltransferase MEC-17 are required for microtubule structure and organization in C. elegans. Current Biol. 22: 1057-65.

Toth, M., Melentijevic, I., Shah, L., Bhatia, A., Lu, K., Talwar, A., Naji, H., Ibanez-Ventoso, C., Ghose, P., Jevince, A., Xue, J., Herndon, L.A., Bhanot, G., Rongo, C., Hall, D.H., and Driscoll, M. (2012) Neurite sprouting and synapse deterioration in the aging C. elegans nervous system. J. Neurosci. 32: 8778-90.

Mancuso, V.P., Parry, J.M., Storer, L., Poggioli, C., Nguyen, K.C.Q., Hall, D.H. and Sundaram, M.V. (2012) Components of the apical extracellular matrix are required to maintain epithelial junction integrity in C. elegans. Development 139: 979-90. 

O’Hagan, R., Piasecki, B., Silva, M., Phirke, P., Nguyen, K.C.Q., Hall, D.H., Swoboda, P. and Barr, M. (2011) The tubulin deglutamylase CCPP-1 regulates the function and stability of sensory cilia in C. elegans. Current Biol. 21: 1685-94. 

Abdus-Saboor, I., Mancuso, V., Palozola, K., Murray, J., Howell, K., Huang, K., Norris, C.R., Hall, D.H. and Sundaram, M.V. (2011) Notch and Ras promote sequential steps of excretory tube development in C. elegans. Development 138:3545-55. 

Neumann, B., Nguyen, K.C.Q., Hall, D.H., Ben-Yakar, A. and Hilliard, M.A. (2011) Axonal regeneration proceeds through axonal fusion in C. elegans neurons. Dev. Dyn. 240: 1365-72 .

Hall, D.H., Hartwieg, E. and Nguyen, K.C. Q. (2012) Modern electron microscopy methods for C. elegans. In Methods in Cell Biology (Ed) Joel Rothman. Academic Press, New York, 93-149.

Albeg, A., Smith, C., Chatzigeorgiou, M., Feitelson, D.G., Hall, D.H., Schaefer, W.R., Miller, D.M. III, and Treinin, M. (2011) C. elegans multi-dendritic sensory neurons: morphology and function. Mol. Cell. Neurosci 46:308-17.

Oren-Suissa, M., Hall, D.H., Treinin, M.,  Shemer, G., and Podbilewicz, B. (2010) The fusogen EFF-1 controls sculpting of mechanosensory dendrites. Science 328: 1285-8.

Altun, Z.F., Chen, B., Thomas, J.H., Wang, Z-W. and Hall, D.H. (2009) A high-resolution map of C. elegans

   gap junction proteins.  Dev. Dynamics 238: 1936-1950.

Zhou, K., Rolls, M.M., Hall, D.H., Malone, C.J. and Hanna-Rose, W. (2009) A ZYG-12-dynein interaction at the

   nuclear envelope defines cytoskeletal architecture in the C. elegans gonad. J. Cell Biol. 186: 229-241.

Wang, J., Farr, G.W., Hall, D.H., Furtak, K., Dreier, L. and Horwich, A.L. (2009) An ALS-linked mutant 

   SOD1 produces a locomotor defect associated with aggregate formation and synaptic dysfunction when

   expressed in neurons of Caenorhabditis elegans. PLoS Genetics Jan;5(1):e1000350. Epub 2009 Jan 23.

Stone, C.E., Hall, D.H. and Sundaram, M.V. (2009) Lipocalin signaling controls unicellular tube development

   in Caenorhabditis elegans. Developmental Biol. 329: 201-211.

Hall, D.H. and Altun, Z. (2008) C. elegans Atlas. Cold Spring Harbor Laboratory Press, 340 pp.

Jauregui, A.R., Nguyen, K.C.Q., Hall, D.H. and Barr, M.M. (2008) C. elegans nephrocystin-1 and

    nephrocystin-4 modulate cilia development and morphogenesis. J Cell Biol.180: 973-88. 

Ciche, T.A., Kim, K-s., Kaufman-Daszczuk, B., Nguyen, K.C.Q. and Hall, D.H. (2008) Cell invasion and

   matricide during symbiont transmission in nematodes. Appl Env Microbiol. 74: 2275-87.

Marza, E., Long, T., Saiardi, A., Eimer, S., Hall, D.H. and Lesa, G. M. (2008) Polyunsaturated fatty acids 

   influence synaptojanin localization to regulate synaptic vesicle recycling. Mol Biol of the Cell 19: 833-42.

Benard, C.Y., Boyanov, A., Hall, D.H. and Hobert, O. (2006) DIG-1, a novel giant protein non-autonomously

   mediates maintenance of nervous system architecture. Development  133: 3329-40.Rowland, A.M., Olsen, J.G., Richmond, J.E., Hall, D.H. and Bamber, B.A. (2006) Presynaptic terminals independently regulate synaptic clustering and autophagy of GABAA receptors in Caenorhabditis elegans.  J. Neuroscience 26: 1711-20.

Chen, B., Hall, D.H. and Chklovskii, D.B. (2006) Wiring optimization can relate neuronal structure and function. PNAS 103: 4723-4728.

Kao, G., Huang, C-c., Hedgecock, E.M., Hall, D.H. and Wadsworth, W. (2006) Role of the laminin  b subunit in C. elegans basement membrane function and development.  Dev. Biol. 290: 211-219.

Shemer, G., Suissa, M., Kolotuev, I., Nguyen, K.C.Q., Hall, D.H., and Podbilewicz, B. (2004) EFF-1 is sufficient to initiate and execute tissue-specific cell fusion in C. elegans.  Current Biology 14: 1587-91.

Berry, K., Bulow, H.E., Hall, D.H. and Hobert, O. (2003) Intracellular tube formation requires a C. elegans  CLIC ion channel homolog.  Science 302: 2134-37.  

 Melendez, A., Talloczy, Z., Seaman, M., Eskelinen, E-L., Hall, D.H., and Levine, B. (2003) Autophagy genes are essential for dauer development and lifespan extension in C. elegans.  Science 301: 1387-91.

Huang, C-c., Hall, D.H., Hedgecock, E.M., Kao, G., Karantza, V., Vogel, B., Hutter, H., Chisholm, A.D.,Yurchenco, P.D., and Wadsworth, W.G. (2003) Laminin a subunits and their role in C. elegans development.  Development 130: 3343-3358.

Herndon, L.A., Schmeissner, P.J., Dudaroneck, J.M., Brown, P.A., Listner, K.M., Paupard, M.C., Hall, D.H., and Driscoll, M. (2002) Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419: 788-794.

Aurelio, O, Hall, DH, and Hobert, O (2002) Immunoglobulin-domain proteins required for maintenance of ventral nerve cord organization. Science 295: 686-690.

Nass, R., Hall, D.H., Miller, D.M. and Blakeley, R.D. (2002) Neurotoxin-induced degeneration of dopamine neurons in C. elegans. PNAS 99: 3264-3269. 



More Information About Dr. David Hall

Neuroscience Department page


Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Albert Einstein College of Medicine
Rose F. Kennedy Center
1410 Pelham Parkway South , Room 601
Bronx, NY 10461

Tel: 718.430.2195
Fax: 718.430.2514

Research Information