Faculty Profile

Dr. David H. Hall, Ph.D.

David H. Hall, Ph.D.

Professor, Dominick P. Purpura Department of Neuroscience

Areas of Research: Connectomics, ciliogenesis, genetic control of axon guidance, axonal transport, and neuronal cell fate in Caenorhabditis elegans, tubulogenesis in nematode epithelia, anatomy of aging in nematode tissues, new methods in EM

Professional Interests

Beginning with his thesis work at Caltech, Hall has been among the pioneers in determining the exact connectivity among fully identified neurons in the adult nematode, a feat that remains unparalleled in higher animals. He began this work with serial thin sections on grids, analyzing data using filmstrips and print stacks prior to the availability of computer support. More recently he has helped to develop a computer platform for quickly analyzing EM data from serial sections, and helped develop new technologies for faster acquisition of EM serial thin sections for SEM, using either the ATUM microtome or focused ion beam milling. These early data have now spawned a growing interest in attempting connectome analysis in higher animals. He is continuing to analyse the male and hermaphrodite circuits in other developmental stages, in collaboration with Scott Emmons.

Selected Publications

Whole-animal connectomes for both Caenorhabditis elegans sexes (2019) Cook, S.J., Jarrell, T.A., Brittin, C., Wang, Y., Bloniarz, A.E., Yakovlev, M.A., Nguyen, K.C.Q., Tang, L.T-H., Bayer, E.A., Duerr, J.S., Bülow, H.E., Hobert, O., Hall, D.H. & Emmons, S.W. Nature 571: 63-71.

Axon-Dependent Patterning and Maintenance of Somatosensory Dendritic Arbors (2019). Ramirez-Suarez NJ, Belalcazar HM, Salazar CJ, Beyaz B, Raja B, Nguyen KCQ, Celestrin K, Fredens J, Færgeman NJ, Hall DH, Bülow HE. Dev Cell. 48:229-244.

The AFF-1 exoplasmic fusogen is required for endocytic scission and seamless tube elongation (2018). Soulavie F, Hall DH, Sundaram MV. Nat Commun. 9(1):1741. doi: 10.1038/s41467-018-04091-1.

C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress (2017) Melentijevic I, Toth ML, Arnold ML, Guasp RJ, Harinath G, Nguyen KC, Taub D, Parker JA, Neri C, Gabel CV, Hall DH, Driscoll M. Nature. 542: 367-371.

Cell-specific a-tubulin isotype regulates ciliary microtubule ultrastructure, intraflagellar transport, and extracellular vesicle biology (2017). Silva M., Morsci N., Nguyen K.C., Rizvi A., Rongo C, Hall D.H., Barr M.M. Curr Biol. pii: S0960-9822(17)30208-7

Glia-derived neurons are required for sex-specific learning in C. elegans (2015) Sammut, M., Cook, S.J., Nguyen, K., Felton, T., Hall, D.H., Emmons, S.W., Poole, R.J. and Barrios, A. Nature 526: 385-90.

Neurite sprouting and synapse deterioration in the aging C. elegans nervous system (2012) Toth, M., Melentijevic, I., Shah, L., Bhatia, A., Lu, K., Talwar, A., Naji, H., Ibanez-Ventoso, C., Ghose, P., Jevince, A., Xue, J., Herndon, L.A., Bhanot, G., Rongo, C., Hall, D.H., and Driscoll, M.. J. Neurosci. 32: 8778-90.

The connectome of a decision making neuronal network (2012) Jarrell, T.A., Wang, Y., Bloniarz, A.E., Brittin, C.A., Xu, M., Thomson, J.N., Albertson, D.G., Hall, D.H. and Emmons, S.W. Science 337: 437- 444.

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans (2012) Herndon, L.A., Schmeissner, P.J., Dudaroneck, J.M., Brown, P.A., Listner, K.M., Paupard, M.C., Hall, D.H., and Driscoll, M.Nature 419: 788-794.

More Information About Dr. David Hall

WormAtlas

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Albert Einstein College of Medicine
Rose F. Kennedy Center
1410 Pelham Parkway South , Room 601
Bronx, NY 10461

Tel: 718.430.2195
Fax: 718.430.2514

Research Information