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Faculty Profile

Robert H. Singer, Ph.D.

Dr. Robert H. Singer

Professor, Department of Anatomy & Structural Biology

Professor, Dominick P. Purpura Department of Neuroscience

Professor, Department of Cell Biology

Co-Chair, Department of Anatomy & Structural Biology

Harold and Muriel Block Chair in Anatomy & Structural Biology

Co-Director, Integrated Imaging Program

Co-Director, Gruss-Lipper Biophotonics Center

 

Professional Interests

Studying Single mRNA Molecules from Cradle to Grave
We seek to understand the expression and movement of mRNA from transcription through degradation and the effect that defects in these processes have on health. We develop methods to label RNA in fixed and living cells using fluorescent probes and develop microscopy techniques and image analysis algorithms to visualize and quantify many mRNAs simultaneously. Using these technologies, we can observe single mRNAs localizing to cytoplasmic compartments such as the leading edge of a fibroblast, the bud tip of yeast or the axonal process of neurons and follow these single mRNAs from transcription, nuclear export through translation and degradation. Because these techniques yield quantitative fluorescence data, we are able to apply mathematical modeling to test mechanistic hypotheses.

 

Selected Publications

 

More Information About Dr. Robert Singer

Singer Laboratory Web Page

ASB Department Web Page

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Contact

Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Golding Building, Room 601
Bronx, NY 10461

Tel: 718.430.8646
Fax: 718.430.8697
robert.singer@einstein.yu.edu

 
Collexis Research Profiles
Einstein Research Profiles (ERP) is one of the innovative technologies to create collaborative bridges within and across the entire bench-to-bedside-to-population spectrum of research. The ERP website has been developed in partnership with Collexis to give investigators easy access to PubMed publications, coauthor networks, information about NIH grants, and research networks.

Media Coverage

Science interviews Dr. Robert Singer, who is identified as a pioneer in the field of mRNA research, about the ongoing search to discover how proteins are placed in their correct destinations within a cell.

Nature interviews Robert Singer, Ph.D., about recent advances in single-cell imaging and the enormous benefits a core facility with this technology provides to an institution’s investigators, students and postdocs.

More media coverage