Professor of Clinical Neurology, The Saul R. Korey Department of Neurology
Assistant Professor, Department of Medicine (Critical Care)
Assistant Professor, Dominick P. Purpura Department of Neuroscience
Director, Eletroencephalography Lab at Montefiore Medical Center, The Saul R. Korey Department of Neurology
Chief of Service for Neurology at the Moses and Wakefield Divisions at Montefiore Medical Center
I have two research interests. First, I am using magnetic resonance spectroscopy in a rat model of epileptogenesis in which rats undergoing status epilepticus may subsequently develop spontaneous seizures. With magnetic resonance, one can non-invasively measure metabolic markers of neuronal mitochondrial and glial "health" serially in the hippocampus following status epilepticus. The magnetic resonance measurements are made during the "latent period", the period of time before seizures develop that the brain is acquiring the epileptic trait. After magnetic resonance studies are completed, rats undergo EEG monitoring to determine whether spontaneous seizures are occuring, i.e. whether the rat is epileptic or not. We hypothesize that comparison of hippocampal measurements in rats developing epilepsy will differ from those without epilepsy. These spectroscopic changes could serve as a marker of epileptogenesis applicable to human epilepsy. Implementation of similar measurements in a human patients using magnetic resonance would be straightforward. Second, I am interested in the the electrophysiolgy underlying seizure onset. In my laboratory, we are using a rat model of focal seizures to study the role of gamma (40-80Hz) oscillations and higher frequency (>80Hz) oscillations at seizure onset. It is hypothesized that these oscillations play a critical role in the transition to the seizure state. In collaboration with colleagues at Montefiore Medical Center and in the Department of Neuroscience, I am also developing a comparable analysis of EEG recordings from human patients undergoing intracranial monitoring as part of an evaluation for possible epilepsy surgery. From the laboratory work the goal is to better understand the role of particular cortical neuronal groups in generating "runaway synchrony" underlying seizure onset. From the clinical study the goal is to determine whether the origin and spread of fast oscillations can be used to delineate the "epileptic zone" and improve outcome following surgery.
Currently the Chairman of the Educational Development Committee for the American Epilepsy Society.
Lado FA, Sun W, Pan C, and Hetherington H (2006) Can 1H-Spectrosopy Prospectively Identify Rats Undergoing Epileptogenesis Following Status Epilepticus? abstract no. 3.053 presented at the American Epilepsy Society Annual Meeting, San Diego (http://www.aesnet.org/Visitors/AnnualMeeting/Abstractsnew/dsp_Abstract.cfm?id=679)
Gomes W, Lado F, de Lanerolle N, and Hetherington H (2006) NAA and Epileptogenesis in a Rat Model of Epilepsy, abstract no 4.056 presented at the American Epilepsy Society Annual Meeting, San Diego (http://www.aesnet.org/Visitors/AnnualMeeting/Abstractsnew/dsp_Abstract.cfm?id=906)
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