Faculty Profile

Dr. Solomon L. Moshe, M.D.

Solomon L. Moshe, M.D.

Professor, The Saul R. Korey Department of Neurology

Professor, Department of Pediatrics

Professor, Dominick P. Purpura Department of Neuroscience

Charles Frost Chair in Neurosurgery and Neurology

Director, Division of Neurology, Department of Pediatrics

Director, Division of Pediatric Neurology, The Saul R. Korey Department of Neurology

Director, Clinical Neurophysiology, The Saul R. Korey Department of Neurology

Areas of Research: The study of antiepileptogenesis following traumatic brain injury, intractable age specific epilepsies and their consequences, and subcortical circuits involving the control of seizures

Professional Interests

Since 1979, Dr. Moshé’s research has focused on translational approaches to understand the mechanisms underlying the development of epilepsy and its consequences in infants and children. His laboratory has developed and patented an animal model that replicates human infantile spasms. In collaboration with Dr Aristea Galanopoulou, this model is being used to identify novel treatments of this devastating condition. His work has identified an endogenous brain circuit that can control the expression of seizures as a function of age and gender. Recent research interests include mehanisms of antiepileptogenesis following traumatic brain injury. In addition to his laboratory research, he is actively involved in several large, multi-center studies examining the outcomes of prolonged, febrile seizures (seizures occurring with fever) and absence epilepsy to identify predictive biomarkers of the course and response to treatment and also how to design effective participatory action reseach trials with the collaboration of consumers, caregivers and advocacy groups.  Dr. Moshé has mentored numerous scientists and clinicians from around the world in clinical epilepsy and basic science epilepsy-related research.

 Dr. Moshé is active in numerous professional societies and elected President of the International League against Epilepsy, the American Epilepsy Society, the American Clinical Neurophysiology Society, the Eastern Association of Electroencephalographers.  He is an elected member of the American Neurological Association and the American Pediatric Society.  

Dr. Moshé is the recipient of several honors and awards, including the Teacher-Investigator Development Award from NINDS; the 1995 Jacob Javits Neuroscience Investigator Award from NINDS; the 1984 Michael Prize for Achievements in Epilepsy Research; the 1990 American Epilepsy Society Research Award; the 1999 Ambassador for Epilepsy Award from the International League Against Epilepsy; the 2005 Gloor Award from the American Clinical Neurophysiology Society; the 2007 J.E. Purkyne Honorary Medal in Biomedical Research by the Czech Academy of Sciences; the 2008 Mentor of the Year Award from Albert Einstein College of Medicine; the 2010 Global and Awareness Award from CURE, Citizens United for Research in Epilepsy; the First 2012 Saul R. Korey Award in Translational Science and Medicine, Albert Einstein College of Medicine and the 2017 Bernard Sachs Award from the Child Neurology Society. 

Selected Publications

Pitkanen A, Buckmaster P, Galanopoulou AS, Moshé SL Models of seizures and epilepsy, Second Edition Elsevier (2017).

Shandra O, Moshe SL, Galanopoulou AS.  “Inflammation in epileptic encephalopathies.”  In Advances in Protein Chemistry and Structural Biology 108:59-84 (2017).

Galanopoulou AS, Mowrey W, Liu W, Li Q, Shandra O, Moshe SL.   Preclinical screening for treatments for infantile spasms in the multiple hit rat model of infantile spasms: an update.   Neurochemical Research, 42:1949-61 (2017).

Nariai H, Beal J, Galanopoulou AS, Mowrey W, Bickel S, Sogawa Y, Jehle R, Shinnar S, Moshe SL.  Scalp EEG Ictal Gamma and Beta Activity during Infantile Spasms: Evidence of Focality.  Epilepsia 58:882-892 (2017). 

Gallentine W.B., Shinnar S, Hesdorffer D.C., Epstein L, Nordli D.R., Pellock J.M., Lewis D.V., Frank M, Seinfeld S, Shinnar R.C., Cornett K, Liu B, Moshe S.L., Sun S, FEBSTAT Investigator Team.  Plasma Cytokines Associated with Febrile Status Epilepticus in Children: A Potential Biomarker for Acute Hippocampal Injury.  Epilepsia 58:1102-1111(2017).

Robbins M.S., Haut S.R., Lipton R.B., Milstein M.J., Ocava L.C., Ballaban-Gil K, Moshe S.L., Mehler M.F.  A dedicated scholarly research program in an adult and pediatric neurology residency program.  Neurology 88:1366-1370 (2017).

Fisher R, Cross J, French J, Higurashi N, Hirsch E, Jansen F, Lagae L, Moshe SL, Peltola J, Roulet-Perez E, Scheffer I, Zuberi S.  Operational Classification of Seizure Types by the International League Against Epilepsy.  Epilepsia 58:522-530 (2017)

Fisher R, Cross J, D’Souza C, French J, Haut S, Higurashi N, Hirsch E, Jansen F, Lagae L, Moshe SL, Peltola J, Roulet-Perez E, Scheffer I, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi S.  Instruction manual for the ILAE 2017 Operational Classification of seizures types.  Epilepsia 58:531-542 (2017).

Scheffer IE, French J,  Hirsch E, Jain S, Mathern GW, Moshé SL, Perucca E, Tomson T, Wiebe S, Zhang Y, Zuberi SM. Classification of the epilepsies: New concepts for discussion and debate. Special Report of the ILAE Classification Task Force of the Commission for Classification and Terminology. Epilepsia 58:512-521 (2017).

Sauro KM, Wiebe S, Dunkley C, Janszky J, Kumlien E, Moshé SL, Nakasato N, Pedley TA, Perucca E, Senties H, Thomas SV, Wang Y, Wilmshurst J, Jette N. The current state of epilepsy guidelines: A systematic review. Epilepsia 57:13-23 (2016). 

Capovilla G, Kaufman K, Perucca E, Moshé SL, Arida RM, Epilepsy, Seizures, Physical Exercise and Sports: A report from the ILAE Task Force on Sports and Epilepsy. Epilepsia 57:6-12 (2016).

Spiciarich M, Moshé SL. Case Report: Voltage Gated P/Q Type Calcium Channel Antibodies Associated with Cerebellar Degeneration in a female child. Ped. Neurol, 62:43-46 (2016).  

Hesdorffer DC, Shinnar S, Lax DN, Pellock JM, Nordli DR, Seinfeld S, Gallentine W, Frank LM, Lewis DV, Shinnar RC, Bello JA, Chan S, Epstein LG, Moshé SL, Liu B, Sun S. Risk factors for subsequent febrile seizures in the FEBSTAT study. Epilepsia 57:1042-47 (2016). 

Djukic A, Holtzer R, Shinnar S, Muzumdar H, Rose SA, Mowrey W, Galanopoulou AS, Shinnar R, Jankowski JJ, Feldman JF, Pillai S, Moshé SL. Pharmacologic Treatment of Rett Syndrome With Glatiramer Acetate. Ped. Neurol. 61:1-7 (2016)

McClelland AC, Gomes WA, Shinnar S, Hesdorffer DC, Bagiella E,  Lewis DV, Bello JA, Chan S, MacFall J,  Chen M, Pellock JM, Nordli Jr DR, Frank M, Moshé S, Shinnar RS, Sun S. Quantitative evaluation of medial temporal lobe morphology in children with febrile status epilepticus: Results of the FEBSTAT study. Am. J. Neuroradiology 37:2356-2362 (2016). 

Gitlevich T, Lado AF, Moshé SL. Kozhevnikov-Rasmussen Syndrome: A Historical perspective spanning two centuries. J. Ped. Epilepsy  5:168-175 (2016)

Moshé SL, Galanopoulou AS. Impaired consciousness in absence epilepsy. Lancet Neurology 15:1298-1299 (2016).

Weiss EF, Masur D, Shinnar S, Hesdorffer DC, Hinton VJ, Bonner M, Rinaldi J, Van de Water V, Culbert J, Shinnar RC, Seinfeld S, Gallentine W, Nordli DR Jr, Frank LM, Epstein L, Moshé SL, Sun S; FEBSTAT study team. Cognitive functioning one month and one year following febrile status epilepticus. Epilepsy Behav. 64:283-288 (2016). 

Akman O, Moshe SL, Galanopoulou AS. Early life status epilepticus and stress have distinct and sex-specific effects on learning, subsequent seizure outcomes, including anticonvulsant response to Phenobarbital. CNS Neurosci. & Therapeutics 21:181-192 (2015).

Moshé, SL, Perucca, E, Ryvlin, P, Tomson Torbjõrn. Epilepsy: new advances. Lancet 385:884-898 (2015).

Jette N, Berghi E, Hesdorffer DC, Moshe SL, Zuberi S, Medina M, Bergen D. ICD coding for epilepsy: Past, present and future – A report by the International League Against Epilepsy Task Force on ICD codes in epilepsy. Epilepsia 56:348-355 (2015).

Chudomel O, Hasson H, Bojar M, Moshe SL, Galanopoulou AS. Age and sex-related characteristics from tonic GABA currents in the rat substantia nigra pars reticulata. Neurochemical Res. 40:747-57 ( 2015) 

Moshé, SL, Cross. KJ. De Bellescize, J, de Vries, L, Nordli, D, Vigevano, F. (eds). Seizures and Syndromes of onset in the Two First Years of Life. In: Progress in Epileptic Disorders . John Libbey Eurotext , publ., vol. 13 (2015).

Seinfeld S, Shinnar S, Sun S, Hesdorffer DC, Deng X, Shinnar RC, O'Hara K, Nordli DR Jr, Frank LM, Gallentine W, Moshé SL, Pellock JM; FEBSTAT study team. Emergency management of febrile status epilepticus: Results of the FEBSTAT study. Epilepsia. 55(3):388-95 (2014).

Lewis, DV, Shinnar, S, Hesdorffer, DC, Bagiella, E, Bello, JA, Chan, S, Moshé, SL et al. Hippocampal sclerosis after febrile status epilepticus: The FEBSTAT Study. Annals Neurol. 75:178-85 (2014).

Overby PJ, Beal JC, Yozawitz EG, Moshé, SL. Introduction of a Pediatric Hospitalist Service with Continuous Electroencephalography Monitoring at a Children’s Hospital. Neurohospitalist 4:74-79 (2014).

Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, Engel J Jr, Forsgren L, French JA, Glynn M, Hesdorffer DC, Lee BI, Mathern GW, Moshé SL, Perucca E, Scheffer IE, Tomson T, Watanabe M, Wiebe S. A practical clinical definition of epilepsy. Epilepsia 55:475-82 (2014).

Simonato, M, Brooks-Kayal, AR, Engel J, Galanopoulou AS, Jensen FE, Moshe SL, O’Brien TJ, Pitkanen A, Wilcox KS, French JA. The challenge and promise of epilepsy therapy development in animal models. Lancet Neurol. 13:949-60 (2014)

Akman, O, Moshé, SL, Galanopoulou, AS. Sex-specific consequences of early life seizures. Neurobiol. Dis. 72:153-166 (2014)

Giorgi, FS, Galanopoulou, AS, Moshé, SL. Sex dimorphism in seizure-controlling networks. Neurobiol. Dis. 72:144-152 (2014).

Ramesh AK, Hagler S, Beal JC, Moshé SL. Pearls & Oy-sters: CSF analysis and the therapeutic paradox” in tuberculous meningitis. Neurology  83:e145-6 (2014)

Vinayan KP, Moshé, SL. Neonatal Seizures and Epilepsies. International Journal of Epilepsy. 1:75-83 (2014).

Galanopoulou, AS, Moshé, SL. Neuronal Network Mechanisms-Sex and Development.
In: Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics. Faingold, C. & Blumenfeld, H. eds., Chapt. 11, pgs 145-153 ,  Elsevier, publ. (2014).

Galanopoulou, AS, Moshé, SL. Epilepsy: Experimental Models. In: Encyclopedia of the Neurological Sciences. Aminoff MJ, and Daroff RB (eds), 2nd edition, vol. 2, ppg 112-117, Oxford Academic Press (2014).

Sanmaneechai, O, Sogawa, Y, Silver, W, Ballaban-Gil, K, Moshé, S, Shinnar, S. Treatment outcome of West Syndrome in infants with Down syndrome. Ped. Neurol.48:42-47 (2013),

Sanmaneechai, O, Song, JL, Nevadunsky, N, Moshé, S, Overby, PJ. Anti-N-metyl-D-aspartate encephalitis with ovarian cystadenofibroma. Ped. Neurol. 48:232-235 (2013).

Gygax, M.J. and Moshé, SL. Animal models of early life seizures and epilepsies. Neurology Asia  18:5-7 (2013).

Dlugos, D., Shinnar, S., Cnaan, A., Hu, F., Moshé, S., Mizrahi, E., Masur, D., Sogawa, Y., Levine, C., Hirtz, D., Clark, P., Adamson, P., Glauser, T. for the Childhood Absence Epilepsy Study Team. Pre-treatment EEG in newly diagnosed childhood absence epilepsy: Associations with neuropsychlogical status and initial treatment outcome. Neurology 81:150-156 (2013)

Blumcke, I., Thom, M., Aronica, E., Armstrong, D.D., Bartolomei, F., Bernasconi, A., Bien, C.G., Cendes, F., Coras, R., Cross, H., Jacques, T.S., Kahane, P., Mathern, G.W., Miyata, H., Moshé, S.L., Oz, B., Ozkara, C., Perucca, E., Sisodiya, S., Wiebe, S., Spreafico, R. International Consensus Classification of Hippocampal Sclerosis in Temporal Lobe Epilepsy: A Task Force Report from the ILAE Commission on Diagnostic Methods. Epilepsia 54:1315-29 (2013).

Moshé, SL, and Perucca, E. Epileptic Disorders to become the educational journal of ILAE. Epileptic Disorders 15:99 (2013).

Ono, T, Galanopoulou, AS, and Moshé, SL. Getting rid of the catastrophe: frontier research in infantile spasms. Epilepsy & Seizure, J. Japan Epilepsy Soc. 6:19-29 (2013).

Wilcox, KS, Dixon-Salazar, T, Sills, GJ, Ben-Menachem, E, White, HS, Porter, RJ, Dichter, MA, Moshé, SL, Noebels, JL, Privitera, MD, Rogawski, MA. Issues related to development of new antiseizure treatments. Epilepsia 54:24-34 (2013).

Engel, J, Pitkãnen, A, Loeb, JA, Dudek, E, Bertram EH, Cole, AJ, Moshé, SL, Wiebe, S, Fureman, BE, Jensen, FE, Mody, I, Nehlig, A, Vezzani, A. Epilepsy Biomakers. Epilepsia 54:61-69 (2013)

Hesdorffer, DC, Shinnar, S., Lewis, DV, Nordli, DR, Pellock, JM, Moshé, SL, Shinnar, RC, Litherland, C., Bagiella, E., et al. Risk factors for febrile epilepticus: a case-control study. J. Pediatrics  163:1147-51 (2013).

 Lado, F, Rubboli, G, Capovilla, G, Avanzini, G, Moshé, SL. Pathophysiology of Epileptic Encephalopathies. Epilepsia 54:6-13 (2013).

Capovilla, G., Moshé, SL, Wolf, P, Avanzini G. Epileptic encephalopathy as models of system epilepsy. Epilepsia 54:34-37 (2013).

More Information About Dr. Solomon Moshe

Developmental Epilepsy Laboratory

Clinical Programs in Child Neurology and Neurophysiology at Montefiore Medical Center

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Albert Einstein College of Medicine
Rose F. Kennedy Center
1410 Pelham Parkway South , Room 316
Bronx, NY 10461

Tel: 718.430.2447

Research Information

In the News

The Washington Post interviews Dr. Solomon Moshé about the case of a girl with a rare form of epilepsy that causes uncontrolled bouts of laughter.

WebMD interviews Dr. Solomon Moshé about a new study that found treatment-resistant epilepsy is linked to autism.

More media coverage