Professor, Department of Pathology
Chair, Department of Pathology
In 1999 we developed a multidisciplinary group including surgery, oncology, pathology, molecular biology, protein chemistry, computational biology and biostatistics to study Head and Neck Squamous Cell Carcinoma (HNSCC). Our initial studies on molecular classification of HNSCC using microarray technology demonstrated that patient segregation by gene expression profiling is a better predictor of outcome than established clinicopathological variables. The Head and Neck Program includes multiple laboratories with research exploring basic mechanisms of tumor behavior, developing biomarkers and identifying molecular classifiers that define distinct subsets of patients. Studies in the Prystowsky Laboratory focus on identifying proteomic signatures that predict tumor behavior. The Head and Neck program goals are:
Childs G, Fazzari M, Kung G, Kawachi N,Brandwein-Gensler M, McLemore M, Chen Q, Burk RD, Smith RV, Prystowsky MB, Belbin TJ. Schlecht NF (2009) Low level expression of microRNA's let7-d and miR-205 are prognostic markers of head and neck squamous cell carcinoma. Amer J Pathol 174(3):736-745.
Prystowsky MB, Adomako A, Smith RV, Kawachi N, McKimpson W, Atadja P, Chen Q, Schlecht NF, Parish JL, Childs G, Belbin TJ (2009) The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma cell lines. Journal of Pathology, 218:467-477.
Schlecht NF, Brandwein-Gensler M, Nuovo GJ, Li M, Dunne A, Kawachi N, Smith RV, Burk RD, Prystowsky MB (2011) A comparison of clinically utilized human papillomavirus detection methods in head and neck cancer. Modern Pathology 24:1295-1305.
Smirnova T, Adomako A, Locker J, Van Rooijen N, Prystowsky MB, Segall JE (2011) In vivo invasion of head and neck squamous cell carcinoma cells does not require macrophages. Am J Pathol 178:2857-2865.
Lleras R, Adrien LR, Smith RV, Harris TM, Liveras A, Schlecht NS, Childs G, Prystowsky MB, Belbin TJ (2011)Hypermethylation of a cluster of kruppel-type zinc finger protein genes on chromosome 19q13 in oropharyngeal squamous cell carcinoma. Am J Pathol, 178:1965-1974.
Harris T, Jimenez L, Kawachi N, Fan J-B, Chen J, Belbin T, Ramnauth A, Loudig O, Keller CE, Smith R, Prystowsky MB, Schlecht NF, Segall JE, Childs G (2012) Low-Level expression of miR-375 Correlates with Poor Outcome and Metastasis While Altering the Invasive Properties of Head and Neck Squamous Cell Carcinomas Am J Pathol, 180:917-928.
Loudig O, Brandwein-Gensler M, Kim R, Lin J, Isayeva T, Liu C, Segall JE, Kenny PA, Prystowsky MB (2012) Illumina whole-genome DASL platform: assessing its performance in formalin-fixed paraffin-embedded samples and identifying invasion pattern-related genes in oral squamous cell carcinoma. Human Pathology 42:1911-1922.
Schlecht N, Brandwein-Gensler M, Smith RV, Kawarchi N, Broughel D, Lin J, Keller CE, Reynolds PA, Gunn-Moore FJ, Harris T, Childs, G, Belbin TJ, Prystowsky MB (2012) Cytoplasmic ezrin and moesin correlate with poor survival in head and neck squamous cell carcinoma. Head and Neck Pathology 6:232-243.
More Information About Dr. Michael Prystowsky
Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.
Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Belfer Building, Room 713
Bronx, NY 10461