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Faculty Profile

David L. Goldman, M.D.

Dr. David L. Goldman

Associate Professor, Department of Pediatrics (Infectious Diseases)

Assistant Professor, Department of Microbiology & Immunology

 

Professional Interests

The medical community has long recognized fungi as important allergens for patients with asthma. Interestingly, fungal sensitization is more common in children and has been linked to severe asthma resulting in death. The accepted paradigm is that fungal sensitization occurs as a result of recurrent, transient environmental exposures. Yet, increasing evidence suggests that fungi may interact with people in unrecognized ways to promote asthma. My lab is interested in understanding the role of subclinical fungal infections in asthma and their potential contribution to the high prevalence of asthma in urban areas.

Cryptococcus neoformans is an encapsulated fungus that is well suited to serve as co-factor in urban asthma. C. neoformans colonizes pigeon droppings and is endemic to urban areas. Once inhaled, this fungus causes persistent, subclinical infections. We have demonstrated that the majority of Bronx children older than 2 years have serologic evidence of cryptococcal infection. Cryptococcal infection induces TH2 inflammation in animal models. In a rat model, we have shown that cryptococcal pulmonary infection acts a co-factor to enhance allergic inflammation to allergen challenge and promotes airway hyper-responsiveness, both hallmark features of asthma. Pulmonary cryptococcosis also induces chitinase expression, which has recently been implicated as an essential mediator of allergic inflammation.

To study this phenomenon, we have established collaborations with Pulmonary Medicine, Critical Care and Emergency Medicine at the Children’s Hospital of Montefiore. These collaborations provide access to the large number of children with asthma in the Bronx. Current studies underway include a characterization of chitinase expression among asthmatics and a comparison of cryptococcal infection prevalence among asthmatics and non-asthmatics. Animal experimentation directed at understanding the mechanisms and variables related to fungal induced asthma are also underway.

In addition to fungal studies, my lab is interested in anthrax pathogenesis. Bacillus anthracis is widely recognized as a potential agent of bioterrorism as evidenced by the 2001 anthrax attack. The toxins of B. anthracis are essential to virulence. In collaborations with Drs. Arturo Casadevall and Jurgen Brojatsch, we have studied the mechanisms by which Bacillus anthracis toxins contribute to host death. We have identified a previously unrecognized protease in human serum that inactivates the protective antigen component of lethal toxin in vitro. The precise protease and its role in the host response and susceptibility to anthrax remain to be determined. We have also identified a potential role for platelet activating factor (PAF) in mediating the lethal effects of toxin, including the alterations in vascular permeability which is characteristic of anthrax. Together, these observations may have important implications in developing new approaches to the treatment of anthrax.

 

Selected Publications

Pharmacotherapy of cryptococcosis.

Ritter M, Goldman DL.

Expert Opin Pharmacother. 2009 Aug 27. [Epub ahead of print]

PMID: 19708853 [PubMed - as supplied by publisher]:

 

A role for chitin and chitooligomers in the capsular architecture of Cryptococcus neoformans.

Fonseca FL, Nimrichter L, Cordero RJ, Frases S, De Siqueira JR, Goldman DL, Andruszkiewicz R, Milewski S, Travassos LR, Casadevall A, Rodrigues ML.

Eukaryot Cell. 2009 Jul 17. [Epub ahead of print]

PMID: 19617395 [PubMed - as supplied by publisher]

 

Neurologic manifestations associated with parvovirus B19 infection.

Douvoyiannis M, Litman N, Goldman DL.

Clin Infect Dis. 2009 Jun 15;48(12):1713-23. Review.

PMID: 19441978 [PubMed - indexed for MEDLINE]

 

Potential contribution of fungal infection and colonization to the development of allergy.

Goldman DL, Huffnagle GB.

Med Mycol. 2009 Apr 22:1-12. [Epub ahead of print]

PMID: 19384753 [PubMed - as supplied by publisher]

 

Leuconostoc septicemia in a preterm neonate on vancomycin therapy: case report and literature review.

Janow G, Lambert B, Scheiner M, Rosen O, Goldman DL, Soghier L.

Am J Perinatol. 2009 Jan;26(1):89-91. Epub 2008 Nov 21. Review.

PMID: 19031357 [PubMed - indexed for MEDLINE]

 

A traveler with rash and thrombocytopenia.

Douvoyiannis M, Litman N, Goldman DL.

Clin Pediatr (Phila). 2009 Jun;48(5):568-71. Epub 2008 Nov 21. No abstract available.

PMID: 19028931 [PubMed - indexed for MEDLINE]

 

Loss of allergen 1 confers a hypervirulent phenotype that resembles mucoid switch variants of Cryptococcus neoformans.

Jain N, Li L, Hsueh YP, Guerrero A, Heitman J, Goldman DL, Fries BC.

Infect Immun. 2009 Jan;77(1):128-40. Epub 2008 Oct 27.

PMID: 18955480 [PubMed - indexed for MEDLINE]

 

Antibody responses to Cryptococcus neoformans in Indian patients with cryptococcosis.

Saha DC, Xess I, Zeng WY, Goldman DL.

Med Mycol. 2008 Aug;46(5):457-63. Epub 2008 Mar 10.

PMID: 18608912 [PubMed - indexed for MEDLINE]

 

Fungal killing by mammalian phagocytic cells.

Nicola AM, Casadevall A, Goldman DL.

Curr Opin Microbiol. 2008 Aug;11(4):313-7. Epub 2008 Jun 21. Review.

PMID: 18573683 [PubMed - indexed for MEDLINE]

 

Posterior fossa dermoid cyst with sinus tract and meningitis in a toddler.

Douvoyiannis M, Goldman DL, Abbott IR 3rd, Litman N.

Pediatr Neurol. 2008 Jul;39(1):63-6.

PMID: 18555177 [PubMed - indexed for MEDLINE]

 

Anthrax-associated shock.

Goldman DL, Casadevall A.

Front Biosci. 2008 May 1;13:4009-14. Review.

PMID: 18508494 [PubMed - indexed for MEDLINE]

 

Pulmonary cryptococcosis induces chitinase in the rat.

Vicencio AG, Narain S, Du Z, Zeng WY, Ritch J, Casadevall A, Goldman DL.

Respir Res. 2008 May 15;9:40.

PMID: 18482441 [PubMed - indexed for MEDLINE]

 

Human serum contains a protease that protects against cytotoxic activity of Bacillus anthracis lethal toxin in vitro.

Goldman DL, Zeng W, Rivera J, Nakouzzi A, Casadevall A.

Clin Vaccine Immunol. 2008 Jun;15(6):970-3. Epub 2008 Apr 30.

PMID: 18448623 [PubMed - indexed for MEDLINE]

 

Association between herpes simplex virus-1 infection and idiopathic unilateral facial paralysis in children and adolescents.

Khine H, Mayers M, Avner JR, Fox A, Herold B, Goldman DL.

Pediatr Infect Dis J. 2008 May;27(5):468-9.

PMID: 18360300 [PubMed - indexed for MEDLINE]

 

Spleen deposition of Cryptococcus neoformans capsular glucuronoxylomannan in rodents occurs in red pulp macrophages and not marginal zone macrophages expressing the C-type lectin SIGN-R1.

De Jesus M, Park CG, Su Y, Goldman DL, Steinman RM, Casadevall A.

Med Mycol. 2008 Mar;46(2):153-62.

PMID: 18324494 [PubMed - indexed for MEDLINE]

 

Serologic evidence for reactivation of cryptococcosis in solid-organ transplant recipients.

Saha DC, Goldman DL, Shao X, Casadevall A, Husain S, Limaye AP, Lyon M, Somani J, Pursell K, Pruett TL, Singh N.

Clin Vaccine Immunol. 2007 Dec;14(12):1550-4. Epub 2007 Oct 24.

PMID: 17959819 [PubMed - indexed for MEDLINE]

 

Serologic evidence for regional differences in pediatric cryptococcal infection.

Davis J, Zheng WY, Glatman-Freedman A, Ng JA, Pagcatipunan MR, Lessin H, Casadevall A, Goldman DL.

Pediatr Infect Dis J. 2007 Jun;26(6):549-51.

PMID: 17529880 [PubMed - indexed for MEDLINE]

 

Risk of resistance associated with fluconazole prophylaxis: systematic review.

Brion LP, Uko SE, Goldman DL.

J Infect. 2007 Jun;54(6):521-9. Epub 2007 Jan 18. Review.

PMID: 17239952 [PubMed - indexed for MEDLINE]

 

Enhanced allergic inflammation and airway responsiveness in rats with chronic Cryptococcus neoformans infection: potential role for fungal pulmonary infection in the pathogenesis of asthma.

Goldman DL, Davis J, Bommarito F, Shao X, Casadevall A.

J Infect Dis. 2006 Apr 15;193(8):1178-86. Epub 2006 Mar 9.

PMID: 16544260 [PubMed - indexed for MEDLINE]

 

Phenotypic switching in Cryptococcus neoformans.

Guerrero A, Jain N, Goldman DL, Fries BC.

Microbiology. 2006 Jan;152(Pt 1):3-9. Review.

PMID: 16385110 [PubMed - indexed for MEDLINE]

 

A dual role for TGF-beta1 in the control and persistence of fungal pneumonia.

Shao X, Rivera J, Niang R, Casadevall A, Goldman DL.

J Immunol. 2005 Nov 15;175(10):6757-63.

PMID: 16272332 [PubMed - indexed for MEDLINE]

 

An innate immune system cell is a major determinant of species-related susceptibility differences to fungal pneumonia.

Shao X, Mednick A, Alvarez M, van Rooijen N, Casadevall A, Goldman DL.

J Immunol. 2005 Sep 1;175(5):3244-51.

PMID: 16116215 [PubMed - indexed for MEDLINE]

 

Phenotypic switching of Cryptococcus neoformans can produce variants that elicit increased intracranial pressure in a rat model of cryptococcal meningoencephalitis.

Fries BC, Lee SC, Kennan R, Zhao W, Casadevall A, Goldman DL.

Infect Immun. 2005 Mar;73(3):1779-87.

PMID: 15731079 [PubMed - indexed for MEDLINE]

 

A ten-year-old boy with a pulmonary nodule secondary to Cryptococcus neoformans: case report and review of the literature.

Sweeney DA, Caserta MT, Korones DN, Casadevall A, Goldman DL.

Pediatr Infect Dis J. 2003 Dec;22(12):1089-93. Review.

 

Phagocytic activity and monocyte chemotactic protein expression by pulmonary macrophages in persistent pulmonary cryptococcosis.

He W, Casadevall A, Lee SC, Goldman DL.

Infect Immun. 2003 Feb;71(2):930-6.

PMID: 12540575 [PubMed - indexed for MEDLINE]

 

Phenotypic switching in Cryptococcus neoformans.

Fries BC, Goldman DL, Casadevall A.

Microbes Infect. 2002 Nov;4(13):1345-52. Review.

PMID: 12443899 [PubMed - indexed for MEDLINE]

 

Fcgamma receptor I- and III-mediated macrophage inflammatory protein 1alpha induction in primary human and murine microglia.

Song X, Shapiro S, Goldman DL, Casadevall A, Scharff M, Lee SC.

Infect Immun. 2002 Sep;70(9):5177-84.

PMID: 12183568 [PubMed - indexed for MEDLINE]

 

Serologic evidence for Cryptococcus neoformans infection in early childhood.

Goldman DL, Khine H, Abadi J, Lindenberg DJ, Pirofski La, Niang R, Casadevall A.

Pediatrics. 2001 May;107(5):E66.

PMID: 11331716 [PubMed - indexed for MEDLINE]

 

Fungal morphogenesis and virulence.

San-Blas G, Travassos LR, Fries BC, Goldman DL, Casadevall A, Carmona AK, Barros TF, Puccia R, Hostetter MK, Shanks SG, Copping VM, Knox Y, Gow NA.

Med Mycol. 2000;38 Suppl 1:79-86. Review.

PMID: 11204167 [PubMed - indexed for MEDLINE]

 

Persistent Cryptococcus neoformans pulmonary infection in the rat is associated with intracellular parasitism, decreased inducible nitric oxide synthase expression, and altered antibody responsiveness to cryptococcal polysaccharide.

Goldman DL, Lee SC, Mednick AJ, Montella L, Casadevall A.

Infect Immun. 2000 Feb;68(2):832-8.

PMID: 10639453 [PubMed - indexed for MEDLINE]

 

Phenotypic switching in Cryptococcus neoformans results in changes in cellular morphology and glucuronoxylomannan structure.

Fries BC, Goldman DL, Cherniak R, Ju R, Casadevall A.

Infect Immun. 1999 Nov;67(11):6076-83.

PMID: 10531269 [PubMed - indexed for MEDLINE]

 

Antibody response to Cryptococcus neoformans proteins in rodents and humans.

Chen LC, Goldman DL, Doering TL, Pirofski L, Casadevall A.

Infect Immun. 1999 May;67(5):2218-24.

PMID: 10225877 [PubMed - indexed for MEDLINE]

 

Phenotypic switching in the human pathogenic fungus Cryptococcus neoformans is associated with changes in virulence and pulmonary inflammatory response in rodents.

Goldman DL, Fries BC, Franzot SP, Montella L, Casadevall A.

Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14967-72.

PMID: 9843999 [PubMed - indexed for MEDLINE]

 

Characterization of a murine monoclonal antibody to Cryptococcus neoformans polysaccharide that is a candidate for human therapeutic studies.

Casadevall A, Cleare W, Feldmesser M, Glatman-Freedman A, Goldman DL, Kozel TR, Lendvai N, Mukherjee J, Pirofski LA, Rivera J, Rosas AL, Scharff MD, Valadon P, Westin K, Zhong Z.

Antimicrob Agents Chemother. 1998 Jun;42(6):1437-46.

PMID: 9624491 [PubMed - indexed for MEDLINE]

 

Effect of immune mechanisms on the pharmacokinetics and organ distribution of cryptococcal polysaccharide.

Lendvai N, Casadevall A, Liang Z, Goldman DL, Mukherjee J, Zuckier L.

J Infect Dis. 1998 Jun;177(6):1647-59.

PMID: 9607845 [PubMed - indexed for MEDLINE]

 

Pharmacokinetics and biodistribution of a monoclonal antibody to Cryptococcus neoformans capsular polysaccharide antigen in a rat model of cryptococcal meningitis: implications for passive immunotherapy.

Goldman DL, Casadevall A, Zuckier LS.

J Med Vet Mycol. 1997 Jul-Aug;35(4):271-8.

PMID: 9292424 [PubMed - indexed for MEDLINE]

 

Cryptococcus neoformans meningitis in the rat.

Goldman DL, Casadevall A, Cho Y, Lee SC.

Lab Invest. 1996 Dec;75(6):759-70.

PMID: 8973471 [PubMed - indexed for MEDLINE]

 

Tissue localization of Cryptococcus neoformans glucuronoxylomannan in the presence and absence of specific antibody.

Goldman DL, Lee SC, Casadevall A.

Infect Immun. 1995 Sep;63(9):3448-53.

PMID: 7642276 [PubMed - indexed for MEDLINE]

 

 

 

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Contact

Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Golding Building, Room 702
Bronx, NY 10461

Tel: 718.430.2457
david.goldman@einstein.yu.edu

 
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