Assistant Professor, Department of Medicine (Oncology)
Instructor, Department of Molecular Pharmacology
My research is focused in the following areas:
1. The origins of oncogene dependence in RAS- and RAF- driven malignancies, (primarily lung cancer), and pharmacogenomic profiling utilizing RAS- and RAF-directed therapeutics, specifically MEK inhibitors.
2. Targeting oncogenic / mitogenic signaling in the RAS / PI3K signaling network using combinations of signaling inhibitors.
3. Exploiting feedback in cancer cell signaling for rational drug design.
4. Epigenetic mechanisms of drug-resistance (altered methylation and microRNA's): the long-term goal here is to identify such changes in Taxol-resistant cancer model systems and experimentally manipulate target genes to determine their overall contribution to the resistant phenotype.
5. Drug-induced accelerated senescence as a determinant of tumorigenic potential and response to therapy.
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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Golding Building, Room 201
Bronx, NY 10461