Marquee Middle Image

Faculty Profile

Tanya Dragic, Ph.D.

Dr. Tanya Dragic
 

Professional Interests

Hepatitis C virus (HCV) is a major cause of life-threatening liver disease and currently affects 3% of the global human population. Licensed therapies are ineffective and there is no vaccine. The correlates of protective immunity are poorly understood. It has been shown that the antibody response in HCV-positive individuals largely targets envelope glycoprotein E2. This is the receptor-binding subunit of the HCV envelope that mediates antibody-accessible stages of viral entry. We hypothesize that immunizing mice with soluble E2 (sE2)-derived immunogens coupled with strategies that non-specifically boost innate immunity, will focus the humoral response on functional domains of the protein thereby eliciting high titers of broadly-reactive neutralizing antibodies. We are currently optimizing novel derivatives of sE2 and comparing antibody responses elicited by these novel immunogens in combination with different adjuvants. Monoclonal antibodies (MAbs) derived from animals with the highest neutralizing serum titers will be characterized. Finally, we will seek to identify neutralizing sera, MAbs or combinations of MAbs that can attenuate or prevent outgrowth of viral escape variants. Our studies will have broad implications for designing prophylactic and therapeutic approaches that specifically interfere with HCV entry to block infection.

 

Selected Publications

Relevant publications:

 

Falkowska E., J.P. Gardner, E.G. Cormier, R.J. Durso, R.A. Arrigale, R. Ogawa, G.P. Donovan, P.J. Maddon, Olson W.C. and T. Dragic. (2006) The Role of L-SIGN (CD209L) Polymorphisms in binding and trans-Infection of hepatitis C virus. J. Gen. Virol. 87: 2571

 

Meertens, L., C. Bertaux and T. Dragic. (2006) Hepatitis C Virus Entry Requires a Critical Postinternalization Step and Delivery to Early Endosomes via Clathrin-Coated Vesicles. J. Virol. 80: 11571

 

Bertaux C., D. Daelemans, L. Meertens, E.G. Cormier, J.F. Reinus,  W.J. Peumans, E.J.M. Van Damme, Y. Igarashi, T. Oki, D. Schols, T. Dragic and J. Balzarini. (2007) Entry of Human Immunodeficiency Virus Type 1 and Hepatitis C Virus is Selectively Inhibited by Carbohydrate-Binding Agents but not by Polyanions. Virology 366: 40

 

Falkowska E., F. Kajumo, F. Tsamis, E. Garcia, J. Reinus and T. Dragic. (2007) HCV Envelope Glycoprotein E2 glycans play a role in entry, CD81 binding and neutralization. J. Virol. 81: 8072

Relevant publications:

 

Falkowska E., J.P. Gardner, E.G. Cormier, R.J. Durso, R.A. Arrigale, R. Ogawa, G.P. Donovan, P.J. Maddon, Olson W.C. and T. Dragic. (2006) The Role of L-SIGN (CD209L) Polymorphisms in binding and trans-Infection of hepatitis C virus. J. Gen. Virol. 87: 2571

 

Meertens, L., C. Bertaux and T. Dragic. (2006) Hepatitis C Virus Entry Requires a Critical Postinternalization Step and Delivery to Early Endosomes via Clathrin-Coated Vesicles. J. Virol. 80: 11571

 

Bertaux C., D. Daelemans, L. Meertens, E.G. Cormier, J.F. Reinus,  W.J. Peumans, E.J.M. Van Damme, Y. Igarashi, T. Oki, D. Schols, T. Dragic and J. Balzarini. (2007) Entry of Human Immunodeficiency Virus Type 1 and Hepatitis C Virus is Selectively Inhibited by Carbohydrate-Binding Agents but not by Polyanions. Virology 366: 40

 

Falkowska E., F. Kajumo, F. Tsamis, E. Garcia, J. Reinus and T. Dragic. (2007) HCV Envelope Glycoprotein E2 glycans play a role in entry, CD81 binding and neutralization. J. Virol. 81: 8072

 

Meertens L., C. Bertaux C, L. Cukierman, E. Cormier and T. Dragic. (2008) The tight junction proteins claudin-6 and -9 are entry cofactors for the Hepatitis C virus. J. Virol. 82: 3555

 

Cukierman, L., Meertens, L., Bertaux, C., Kajumo, F. and T. Dragic. Residues in a highly conserved Claudin-1 motif mediate the formation of cell-cell contacts that are required for Hepatitis C virus entry. J. Virol. 83: 5477

 

 

Meertens L., C. Bertaux C, L. Cukierman, E. Cormier and T. Dragic. (2008) The tight junction proteins claudin-6 and -9 are entry cofactors for the Hepatitis C virus. J. Virol. 82: 3555

 

Cukierman, L., Meertens, L., Bertaux, C., Kajumo, F. and T. Dragic. Residues in a highly conserved Claudin-1 motif mediate the formation of cell-cell contacts that are required for Hepatitis C virus entry. J. Virol. 83: 5477

 

 

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Contact

Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Golding Building, Room 403
Bronx, NY 10461

Tel: 718.430.3282
tanya.dragic@einstein.yu.edu

 
Pubmed Search