Faculty Profile

Dr. Philip Aisen, M.D.

Philip Aisen, M.D.

Professor Emeritus, Department of Physiology & Biophysics

Professor Emeritus, Department of Medicine (General Internal Medicine)

Selected Publications

Zak, O. and Aisen, P.: A new method for obtaining human transferrin C-lobe in native conformation: Preparation and properties. Biochemistry, 41:1647-1653, 2002.

Navati, M.S., Samuni, U., Aisen, P. and Friedman, J.M.: Binding and release of iron by gel-encapsulated human transferrin: A conformational search. Proceedings of the National Academy of Sciences, U.S.A., 100: 3832-3837, 2003.

Zak,O., Ikuta,K. and Aisen, P. The synergistic anion-binding sites of human transferrin: Chemical and physiological effects of site-directed mutagenesis. Biochemistry, 41: 7416-7423, 2002.

Dhungana, S., Taboy, C.H., Anderson, D.S., Vaughan, K., Aisen, P. and Crumbliss, A.L., The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin. Proceedings of the National Academy of Sciences, U.S.A., 100: 3659-3664, 2003..

Morris-Jones, R., Youngchim, S., Gomez, B.L., Aisen, P. Hay, R.J., Nosanchik, J.D., Casadevall, A. and Hamilton, A.J., Histoplasmaq capsulatum synthesizes melanin-like pigments in vitro and during mammalian infection. Infection and Immunity, 71: 4026-4033, 2003.

Ikuta, I., Zak, O. and Aisen, P., Recycling, degradation and sensitivity to the synergistic anion of transferrin in the receptor-independent route of iron uptake by human hepatoma (HuH-7) cells. International Journal of Biochemistry and Cell Biology, 36:340-352, 2003.

Zak, O. and Aisen, P., Iron Release from Transferrin, its C-lobe and their Complexes with Transferrin Receptor: the Presence of N-lobe Accelerates Release from C-lobe at Endosomal pH. Biochemistry, 42:12330-12334, 2003.

Liu, R., Guan, J.-Q., Zak, O., Aisen, P. and Chance, M.R., Structural reorganization of transferrin C-lobe and transferrin receptor upon complex formation: C-lobe binds to the receptor helical domain. Biochemistry, 42: 12447-12454, 2003 (Accelerated Publication).

Dhungana, S., Taboy, C., Zak, O., Larvie, M., Crumbliss, A.L. and Aisen, P.: Redox properties of human transferrin bound to its receptor. Biochemistry, 43: 205-209, 2004.

Cheng, Y., Zak, O., Harrison, S.C., Aisen, P. and Walz, T., Structure of the human transferrin receptor-transferrin complex. Cell, 116: 565-576, 2004.

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Research Information