Clinical Assistant Professor, Department of Medicine (Endocrinology)
Research Interest: Physiology and biochemistry of the hypothalamic regulation of hepatic glucose and triglyceride metabolism ("brain-liver" circuit) by nutrients (amino acids) and biochemical mechanisms of diet-induced hepatic insulin resistance.
Arrieta-Cruz I, Knight CM, Gutiérrez-Juárez R. (2015) Acute Exposure of the Mediobasal Hypothalamus to Amyloid-β25-35 Perturbs Hepatic Glucose Metabolism. J Alzheimers Dis. Apr 13. [Epub ahead of print] PubMed PMID: 25869787.
Haeusler RA, Hartil K, Vaitheesvaran B, Arrieta-Cruz I, Knight CM, Cook JR, Kammoun HL, Febbraio MA, Gutierrez-Juarez R, Kurland IJ, Accili D. (2014) Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors. Nat Commun. 2014 Oct 13;5:5190. doi: 10.1038/ncomms6190.
Arrieta-Cruz I, Su Y, Knight CM, Lam TK, Gutiérrez-Juárez R. (2013) Evidence for a role of proline and hypothalamic astrocytes in the regulation of glucose metabolism in rats. Diabetes 62:1152-8.
Su Y, Lam TK, He W, Pocai A, Bryan J, Aguilar-Bryan L, Gutierrez-Juarez R. (2012) Hypothalamic leucine metabolism regulates liver glucose production. Diabetes 61: 85-93.
Knight CM, Gutierrez-Juarez R, Lam TK, Arrieta-Cruz I, Huang L, Schwartz G, Barzilai N, Rossetti L. (2011) Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats. Diabetes 60: 2691-700.
Kishore P, Boucai L, Zhang K, Li W, Koppaka S, Kehlenbrink S, Schiwek A, Esterson YB, Mehta D, Bursheh S, Su Y, Gutierrez-Juarez R, Muzumdar R, Schwartz GJ, Hawkins M. (2011) Activation of K(ATP) channels suppresses glucose production in humans. J Clin Invest 121: 4916-20.
Shishova EY, Stoll JM, Ersoy BA, Shrestha S, Scapa EF, Li Y, Niepel MW, Su Y, Jelicks LA, Stahl GL, Glicksman MA, Gutierrez-Juarez R, Cuny GD, Cohen DE. (2011) Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production. Hepatology 54: 664-74.
Lin HV, Plum L, Ono H, Gutierrez-Juarez R, Shanabrough M, Borok E, Horvath TL, Rossetti L, Accili D. (2010) Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes 59: 337-46.
Lam, TKT*, Gutierrez-Juarez, R*, Pocai, A, Bhanot, S, Tso, P, Schwartz, GJ, and Rossetti, L. (2007): Brain Glucose Metabolism Controls the Hepatic Secretion of Triglyceride-rich Lipoproteins. Nature Medicine 13: 171-180. *, Equal contribution.
Gutierrez-Juarez, R,Â Pocai, A, Mulas, C, Ono, H, Bhanot, S, Monia, BP, and Rossetti, L (2006): Critical Role of Stearoyl-CoA Desaturase-1 (SCD1) in the Onset of Diet-induced Hepatic Insulin Resistance. J Clin Invest. 116:1686-1695.
Lam, TKT, Gutierrez-Juarez, R, Pocai, A, and Rossetti, L. (2005): Regulation of blood glucose by hypothalamic pyruvate metabolism. Science 309:943-947.
Gutierrez-Juarez, R, Obici, S, and Rossetti, L. (2004): Melanocortin-independent effects of leptin on hepatic glucose fluxes. J Biol Chem. 279:49704-49715.
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