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Faculty Profile

Roger Gutierrez-Juarez, M.D., Ph.D.

Dr. Roger Gutierrez-Juarez

Clinical Assistant Professor, Department of Medicine (Endocrinology)

 

Professional Interests

Research Interest: Physiology and biochemistry of the hypothalamic regulation of brain glucose and triglyceride metabolism ("brain-liver" circuit) by nutrients (amino acids) and nutrient-regulated hormones (leptin, insulin) and biochemical mechanisms of diet-induced hepatic insulin resistance.

 

Selected Publications

Su Y, Lam TK, He W, Pocai A, Bryan J, Aguilar-Bryan L, Gutierrez-Juarez R. (2012) Hypothalamic leucine metabolism regulates liver glucose production. Diabetes 61: 85-93.

Knight CM, Gutierrez-Juarez R, Lam TK, Arrieta-Cruz I, Huang L, Schwartz G, Barzilai N, Rossetti L. (2011) Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats. Diabetes 60: 2691-700.

Kishore P, Boucai L, Zhang K, Li W, Koppaka S, Kehlenbrink S, Schiwek A, Esterson YB, Mehta D, Bursheh S, Su Y, Gutierrez-Juarez R, Muzumdar R, Schwartz GJ, Hawkins M. (2011) Activation of K(ATP) channels suppresses glucose production in humans. J Clin Invest 121: 4916-20.

Shishova EY, Stoll JM, Ersoy BA, Shrestha S, Scapa EF, Li Y, Niepel MW, Su Y, Jelicks LA, Stahl GL, Glicksman MA, Gutierrez-Juarez R, Cuny GD, Cohen DE. (2011) Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production. Hepatology 54: 664-74.

Lin HV, Plum L, Ono H, Gutierrez-Juarez R, Shanabrough M, Borok E, Horvath TL, Rossetti L, Accili D. (2010) Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes 59: 337-46.

Lam, TKT*, Gutierrez-Juarez, R*, Pocai, A, Bhanot, S, Tso, P, Schwartz, GJ, and Rossetti, L. (2007): Brain Glucose Metabolism Controls the Hepatic Secretion of Triglyceride-rich Lipoproteins. Nature Medicine 13: 171-180. *, Equal contribution.

Gutierrez-Juarez, R, Pocai, A, Mulas, C, Ono, H, Bhanot, S, Monia, BP, and Rossetti, L (2006): Critical Role of Stearoyl-CoA Desaturase-1 (SCD1) in the Onset of Diet-induced Hepatic Insulin Resistance. J Clin Invest. 116:1686-1695.

Lam, TKT, Gutierrez-Juarez, R, Pocai, A, and Rossetti, L. (2005): Regulation of blood glucose by hypothalamic pyruvate metabolism. Science 309:943-947.

Gutierrez-Juarez, R, Obici, S, and Rossetti, L. (2004): Melanocortin-independent effects of leptin on hepatic glucose fluxes. J Biol Chem. 279:49704-49715.

 

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Contact

Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Golding Building, Room 503
Bronx, NY 10461

Tel: 718.430.2449
roger.gutierrez@einstein.yu.edu

 
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