Harold and Muriel Block Chair in Epidemiology & Population Health
|Primary research interests involve viral and cancer epidemiology, especially as it relates to:
(i) The viral causes of cancer such as human papillomavirus (HPV) and hepatitis C virus (HCV)
(ii) Immunogenetic factors that influence viral infection with HPV, human immunodeficiency virus (HIV), and hepatitis C virus (HCV)
(iii) The hormonal and growth factors influences on viral pathogenesis and tumorigenesis. These include obesity, diabetes, the insulin / insulin-like growth factor axis, sex hormones, and related pathways.
Kuniholm MH, Anastos K, Kovacs A, Gao X, Marti D, Sette A, Greenblatt RM, Peters M, Cohen MH, Minkoff H, Gange SJ, Thio CL, Young MA, Xue X, Carrington M, Strickler HD. Relation of HLA Class I and II Supertypes with Spontaneous Clearance of Hepatitis C Virus. Genes Immun. (In Press)
Abraham AG, Strickler HD, Jing Y, Gange SJ, Sterling TR, Silverberg M, Saag M, Rourke S, Rachlis A, Napravnik S, Moore RD, Klein M, Kitahata M, Kirk G, Hogg R, Hessol NA, Goedert JJ, Gill MJ, Gebo K, Eron JJ, Engels EA, Dubrow R, Crane HM, Brooks JT, Bosch R, D'Souza G; for the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA. Invasive cervical cancer risk among HIV-infected women: A North American multi-cohort collaboration prospective study. J Acquir Immune Defic Syndr. (In Press)
Keller, M.J., Burk, R.D., Xie, X., Anastos, K., Massad, L.S., Minkoff, H., Xue, X., D’Souza, G., Watts, D.H., Levine, A.M., Castle, P.E., Colie, C., Palefsky, J.M., Strickler, H.D. Risk of Cervical Pre-Cancer and Cancer Among HIV-Infected Women With Normal Cervical Cytology and No Evidence of Oncogenic HPV Infection. JAMA. 308: 362-9, 2012.
Rajpathak SN, He M, Sun Q, Kaplan RC, Muzumdar R, Rohan TE, Gunter MJ, Pollak M, Kim, M, Pessin JE, Beasley J, Wylie-Rosett J, Hu FB, Strickler HD. The Insulin-Like Growth Factor Axis and Risk of Type 2 Diabetes in Women. Diabetes. 61: 2248-54, 2012.
Kuniholm MH, Gao X, Xue X, Kovacs A, Marti D, Thio CL, Peters MG, Greenblatt RM, Goedert JJ, Cohen MH, Minkoff H, Gange SJ, Anastos K, Fazzari M, Young MA, Strickler HD*, Carrington*(*Both senior authors contributed equally to this study). Human leukocyte antigen (HLA) genotype and risk of HIV disease progression before and after initiation of antiretroviral therapy. J Virol. 85: 10826-33, 2011.
Massad LS, Xie X, Darragh T, Minkoff H, Levine AM, Watts H, Wright RL, D'Souza G, Strickler HD. Genital warts and vulvar Intraepithelial neoplasia: natural history and effects of treatment and HIV infection. Obstet Gyn. 118: 831-849, 2011.
The Endogenous Hormones and Breast Cancer Collaborative Group* [Strickler HD]. Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies. Lancet Oncology. 11: 530-42, 2010.
Minkoff H, Zhong Y, Burk RD, Palefsky JM, Xue X, Watts DH, Levine AM, Wright RL, Colie C, D'Souza G, Massad LS, Strickler HD. Influence of adherent and effective antiretroviral therapy use on human papillomavirus infection and squamous intraepithelial lesions in HIV-positive women. J Infect Dis. 201: 681-690, 2010.
Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Rohan TE, Manson JE, Li J, Ho GYF, Xue X, Anderson GL, Kaplan RC, Harris TG, Howard BV, Wylie-Rosett J, Burk RD, Strickler HD. Insulin, Insulin-like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women. J Natl Cancer Inst. 101: 48-60, 2009.
More Information About Dr. Howard Strickler
Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.
Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Belfer Building, Room 1312A
Bronx, NY 10461
Reuters and Medscape report on a study led by Dr. Marc Gunter in conjunction with senior author Dr. Howard Strickler, which found that high insulin levels are an independent risk factor for breast cancer, particularly among postmenopausal women who did not use hormone therapy.