Meredith A. Hawkins, M.D.
Professor, Department of Medicine (Endocrinology)
Harold and Muriel Block Chair in Medicine
Director, Global Diabetes Institute
Dr. Meredith Hawkins is a Professor of Medicine in the Diabetes Research and Training Center at the Albert Einstein College of Medicine. Dr. Hawkins earned her M.D. degree cum laude from the University of Toronto and a Master of Science in Clinical Research Methods cum laude from the Albert Einstein College of Medicine. She has served as Associate Editor of the American Journal of Physiology, and as Secretary Treasurer of the American Federation of Medical Research. Dr. Hawkins' current research interests include the effects of nutrient deficiency and excess on insulin resistance, nutritional regulation of adipose tissue inflammation, and the regulation of hepatic glucose production in diabetes mellitus.
Dr. Hawkins is a Beeson Scholar of the American Federation of Aging Research, and has received research grants from the National Institutes of Health, the American Diabetes Association, the Juvenile Diabetes Foundation International and the Diabetes Action Foundation International. She is the recipient of numerous honors and awards, including the Junior Physician Scientist Award (2001) and the Outstanding Investigator Award (2012) from the American Federation of Medical Research, the Novartis Young Investigator award in Diabetes Research (2007), and election to the American Society for Clinical Investigation (2012).
Dr. Hawkins founded and directs Einstein's Global Diabetes Institute (http://www.einstein.yu.edu/centers/global-health/global-diabetes-institute/, with the goal of building strategic partnerships in medical research and education to combat the burgeoning global diabetes epidemic.
- Hawkins M, Barzilai N, Hu M, Chen W, Rossetti L. Role of the glucosamine pathway in fat-induced insulin resistance. J. Clin. Invest 1997; 99:2173-2182. PMCID: PMC508047
- Barzilai N, Massillon D, Vuguin P, Hawkins M, Rossetti L. Leptin Selectively Decreases Visceral Adiposity and Enhances Insulin Action. J. Clin. Invest 1997; 100:3105-3110. PMCID: PMC508523
- Wang J, Liu R, Hawkins M, Barzilai N, Rossetti L. A Nutrient Sensing Pathway Regulates Leptin Gene Expression in Muscle and Fat. Nature 1998; 393:684-688. PMID: 9641678
- Hawkins M, Hu M, Yu J, Eder H, Vuguin P, She L, Barzilai N, Leiser M, Backer J Rossetti L. Discordant Effects of Glucosamine (GlcN) on Insulin-Stimulated Glucose Metabolism and Phosphatidylinositol-3-Kinase (PI3K) Activity. J. Biol. Chem 1999; 274:31312-31319. PMID: 10531330
- Hawkins M, Gabriely I, Wozniak R, Mevorach M, Rossetti L, Shamoon H. The Effect of Glycemic Control on Hepatic and Peripheral Glucose Effectiveness in Type 2 Diabetes Mellitus. Diabetes 2002; 51:2179-89. PMID: 12086948
- Hawkins M, Gabriely I, Wozniak R, Shamoon H, Rossetti L. Fructose Improves the Ability of Hyperglycemia Per Se to Regulate Hepatic Glucose Production (GP) in Type 2 Diabetes. Diabetes 2002; 51:606-614. PMID: 11872657
- Hawkins M, Tonelli J, Kishore P, Stein D, Ragucci E, Gitig A, Reddy K. Contribution of elevated free fatty acid levels to the lack of glucose effectiveness in type 2 diabetes. Diabetes 2003; 52(11):2748-58. PMID: 14578293
- Tonelli J, Li W, Kishore P, Pajvani UB, Kwon E, Weaver C, Scherer PE, Hawkins M. Mechanisms of early insulin-sensitizing effects of thiazolidinediones in type 2 diabetes. Diabetes. 2004; 53(6):1621-9. PMID: 15161771
- Kishore P, Tonelli J, Buse A, Fratila C, Hawkins M. Rapid time-dependent restoration of glucose effectiveness upon lowering free fatty acid levels in type 2 diabetes mellitus. Diabetes 2006; 55:1761-8. PMID: 16731840
- Hwang J-H, Tonelli J, Stein D, Barzilai N, Hawkins M. Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies. Am J. Physiol 2007; 293(6):E1663-9. PMID: 17911339
- Kehlenbrink S, Tonelli J, Koppaka S, Chandramouli V, Hawkins M, Kishore P. Inhibiting gluconeogenesis prevents fatty acid-induced increases in endogenous glucose production. Am J. Physiol 2009; 297(1):E165-73. PMCID: PMC2711655
- Kishore P, Li W, Tonelli J, Lee DE, Koppaka S, Zhang K, Lin Y, Kehlenbrink S, Scherer PE, Hawkins M. Adipocyte-derived factors potentiate nutrient-induced production of plasminogen activator inhibitor-1 by macrophages. Science Translational Medicine. 2010 Feb 24;2(20):20ra15. PMID: 20371491
- Feng D, Tang Y, Kwon H, Zong H, Hawkins M, Kitsis RN, Pessin JE. High-Fat Diet-Induced Adipocyte Cell Death Occurs Through a Cyclophilin D Intrinsic Signaling Pathway Independent of Adipose Tissue Inflammation. Diabetes. 2011 Aug;60(8):2134-43.
- Kishore P, Boucai L, Zhang K, Li W, Su Y, Koppaka S, Kehlenbrink S, Schiwek A, Esterson YB, Mehta D, Bursheh S, Gutierrez-Juarez R, Muzumdar R, Schwartz G, and Hawkins M. Activation of KATP channels suppresses glucose production in humans. J Clin Invest 2011 Dec; 121(12):4916–4920.
- Kishore P, Hu M, Kehlenbrink S, El-Maghrabi R, Hawkins M. Xylitol Infusion Prevents Fat-Induced Insulin Resistance. Diabetologia 2012 Jun;55(6):1808-12. Epub 2012 Mar 30.
- Spiegel AM and Hawkins M. ‘Personalized Medicine’ To Identify Genetic Risks For Type 2 Diabetes And Focus Prevention: Can It Fulfill Its Promise? Health Affairs 31(1):43-9, 2012.
- Crandall JP, Oram V, Trandafirescu G, Reid M, Kishore P, Hawkins M, Cohen HW, Barzilai N. Pilot study of resveratrol in older adults with impaired glucose tolerance. J Gerontol A Biol Sci Med Sci. 2012 Jan 4. [Epub ahead of print]
- Esterson YB, Kishore P, Li W, Zhang K, Tonelli J, Crandall J, Lawrence S, Barzilai N, and Hawkins M. Heightened Stimulation of Plasminogen Activator Inhibitor-1 (PAI-1) by Free Fatty Acids (FFA) in Older Humans. J Gerontol A Biol Sci Med Sci. 2012 Oct 22. [Epub ahead of print]
- Kehlenbrink S, Koppaka S, Cui MH, Huang JH, Hawkins M (co-senior author) and Kishore P. Elevated free fatty acids impair glucose effectiveness by increasing net glycogenolysis. Diabetologia. 2012 Nov;55(11):3021-8. Epub 2012 Jul 31.
- Koppaka S, Kehlenbrink S, Carey M, Li W, Chen J, Wong T, Kehlenbrink S, Carrasco E, Kishore P, Zhang K, and Hawkins M. Reduced adipose tissue macrophage content is associated with improved insulin sensitivity in thiazolidinedione-treated diabetic humans. Diabetes 2013 Feb 8. [Epub ahead of print]
More Information About Dr. Meredith Hawkins
Global Diabetes Institute
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The New York Times interviews Dr. Meredith Hawkins on the results of a clinical trial which showed that an aspirin-like drug helped patients manage their type 2 diabetes.
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