Dr. Herbert Lachman is a physician and behavioral geneticist interested in the molecular and genetic basis of schizophrenia (SZ), autism spectrum disorders (ASD), and bipolar disorder (BD). The lab’s primary research projects involve the use of induced pluripotent stem cells (iPSCs) for modeling neuropsychiatric disorders in vitro. Patient-specific iPCS are generated from skin fibroblasts, which are ultimately induced to differentiate into neurons. Epigenetic analysis and gene expression profiling for protein-coding genes, long non-coding RNAs and microRNAs are being carried out.
In addition, the lab uses gene knockdown and CRISPR knockout approaches to study the effects of SZ, ASD and BD candidate genes on neurogenesis and gene expression. We are particularly interested in those candidate genes that function as transcription factors and chromatin remodeling complexes. The lab has also recently developed an interest in environmental factors that might play a role in SZ and ASD pathogenesis, in particular mediators of the immune response. We are using a differentiation method that converts iPSCs into 3-dimensional neuronal aggregates that resemble a first trimester telencephalon as a model system to study gene x environment interactions in the developing fetal brain.
Dr. Lachman is board certified in Internal Medicine and has clinical responsibilities in the Einstein Division of Substance Abuse, where he is the director of the Medical Maintenance Program. He also teaches human genetics to first-year medical students and graduate students, and directs a course in human genetics in the Clinical Research Training Program.
Selected publications since 2007
Herbert M. Lachman, Cathy S.J. Fann, Michael Bartzis, Oleg V. Evgrafov, Richard N. Rosenthal, Edward V. Nunes, Christian Miner, Maria Santana, Jebediah Gaffney, Amy Riddick, Chia-Lin Hsu, James Knowles (2007) Genomewide Suggestive Linkage of Opioid Dependence to Chromosome 14q. Human Molecular Genetics 16(11):1327-1334
Herbert M. Lachman Oriana A. Petruolo Erika Pedrosa, Tomas Novak, Karen Nolan, Pavla Stopkova (2008). Analysis of protocadherin alpha gene deletion variant in bipolar disorder and schizophrenia (in press: Psychiatric Genetics 18(3):110-115.
Erika Pedrosa, Radu Stefanescu, Oriana Petruolo, Yungtai Lo, Karen Nolan, Pavla Stopkova, Herbert M. Lachman (2008). Analysis of protocadherin alpha gene enhancer polymorphism in bipolar disorder and schizophrenia (Schizophrenia Research). 102 (1-3):210-219.
Rael D. Strous MD, Michael S. Ritsner MD PhD, Shmulik Adler BA, Yael Ratner MD, Rachel Maayan PhD, Moshe Kotler MD, Herbert Lachman MD, Abraham Weizman MD (2009) Improvement of Aggressive Behavior and Quality of Life Impairment Following S-Adenosyl-Methionine (SAM-e) Augmentation in Schizophrenia Eur. Neuropsychopharm. in press 19(1):14-22
Erika Pedrosa, Joseph Locker, Herbert M. Lachman (2009).Survey of schizophrenia and bipolar disorder candidate genes using chromatin immunoprecipitation and tiled microarrays (ChIP-chip) Journal of Neurogenetics, 18:1-12.
Erika Pedrosa, Karen A. Nolan, Radu Stefanescu, Pnina Hershcovitz, Tomas Novak, Ilja Zukov, Pavla Stopkova (2009) Herbert M. Lachman Analysis of a promoter polymorphism in the SMDF neuregulin 1 isoform in schizophrenia Neuropsychobiology 59:205-212.
Joshua T Kantrowitz, Karen Nolan, Srijan Sen, Arthur Simen, Herbert Lachman, Malcolm B Bowers (2009) Adolescent Cannabis Use, Psychosis and Catechol-O-Methyltransferase Genotype in African Americans and Caucasians. Psychiatr Q. 2009 Jul 25. [Epub ahead of print].
Erika Pedrosa, Abhishek Shah, Christopher Tenore, Michael Capogna, Catalina Villa, Herbert M. Lachman. Beta-catenin promoter ChiP-chip reveals potential schizophrenia and bipolar disorder gene network. J Neurogenet. 2010 Dec;24(4):182-93
Abhishek K. Shah, Nina M Tioleco, Karen Nolan, Joseph Locker, Katherine Groh, Catalina Villa, Tomas Novak, Pavla Stopkova, Erika Pedrosa, Herbert M. Lachman Rare NRXN1 promoter variants in patients with schizophrenia. Neuroscience Letters, 2010 475(2):80-4
Pedrosa E, Sandler V, Shah A, Carroll R, Chang C, Rockowitz S, Guo X, Zheng D, Lachman HM. Development of Patient-Specific Neurons in Schizophrenia Using Induced Pluripotent Stem Cells. J Neurogenet. 2011, 25(3):88-103
Mingyan Lin, Erika Pedrosa, Abhishek K. Shah, Anastasia Hrabovsky, Shahina Maqbool, Deyou Zheng, Herbert M. Lachman. Deep sequencing transcriptome analysis of human neurons derived from induced pluripotent stem cells identifies candidate long non-coding RNAs involved in neurogenesis and neuropsychiatric disorders. PLoS One, 2011;6(9):e23356.
Mingyan Lin, Anastasia Hrabovsky, Erika Pedrosa, Tao Wang, Deyou Zheng, Herbert M. Lachman. Allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders. PLoS One. 2012;7(8):e44017. Epub 2012 Aug 30.
Jian Chen, Mingyan Lin, John J. Foxe, Erika Pedrosa, Anastasia Hrabovsky, Reed Carroll, Deyou Zheng, Herbert M. Lachman Transcriptome comparison of human neurons generated using induced pluripotent stem cells derived from dental pulp and skin fibroblasts. PLoS One. 2013 Oct 3;8(10):e75682. doi: 10.1371/journal.pone.0075682. eCollection 2013. PMID: 24098394
Patch-Clamp Recordings Followed by Single-Cell PCR Reveal the Rise and Fall of 13 Genes in iPSC-Derived Human Neurons. Glenn S. Belinsky, Matthew T. Rich, Carissa L. Sirois, Shaina M. Short, Erika Pedrosa, Herbert M. Lachman, and Srdjan D. Antic. Stem Cell Res. 2014 Jan;12(1):101-18. PMID: 24157591
Characterization of Human Pseudogene-derived Non-coding RNAs for Functional Potential Xingyi Guo, Mingyan Lin, Shira Rockowitz, Herbert M. Lachman, and Deyou Zheng. PLOS ONE Published: April 03, 2014 DOI: 10.1371/journal.pone.0093972
Mingyan Lin, Dejian Zhao, Anastasia Hrabovsky, Erika Pedrosa, Deyou Zheng, Herbert M. Lachman. Gene expression profiling in an induced pluripotent stem cell model of the developing human telencephalon: effects of heat shock and its potential consequences in the development of neuropsychiatric disorders. PLoS One. 2014 Apr 15;9(4):e94968. doi: 10.1371/journal.pone.0094968. eCollection 2014.
Shira Rockowitz, Wen-Hui Lien, Erika M Pedrosa, Gang Wei, Mingyan Lin, Keji Zhao, Herbert M Lachman, Elaine Fuchs, Deyou Zheng Comparison of REST cistromes across human cell types reveals common and context-specific functions. PLOS Computational Biology. 2014 (in press)
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