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Faculty Profile

John J. Foxe, Ph.D.

Dr. John J. Foxe

Professor, Department of Pediatrics

Professor, Dominick P. Purpura Department of Neuroscience

Director of Research of the Children's Evaluation and Rehabilitation Center, Department of Pediatrics

 

Professional Interests

I am a translational researcher with a history of research studies on the basic neurophysiology of schizophrenia and autism. My work places special emphasis on the identification of endophenotypic markers in childhood neuropsychiatric diseases and in the linking of these biomarkers to the underlying genotype. Work in our lab has a consistent history of NIH and NSF funding, and a strong record of research productivity (160+ publications). Before joining the faculty at Einstein in January of 2010 (my alma mater), I served for 6 years as the Director of the PhD Program in Cognitive Neuroscience at The City College of New York. I was recruited to Einstein in January of 2010 as Director of Research for the Children’s Evaluation and Rehabilitation Center (CERC), with a mandate to develop and coordinate clinical pediatric research across the college.  Our lab employs an integrated multi-methodological approach to issues in the cognitive neurosciences, using structural and functional neuroimaging, high-density electrophysiology, imaging genomics, eye tracking, psychophysics and virtual reality to understand the neural basis of basic sensory-perceptual and cognitive functions. The work is translational at its core in that it employs an equal mix of basic-science projects in healthy individuals with clinical studies in patient populations. The approach taken is to first develop novel assays of a given perceptual or cognitive function in healthy individuals, which are then deployed in clinical populations of interest. The core mission of the lab is to understand the underlying neurobiology of developmental disorders, with a specific emphasis on Autism. The central goal is to develop more effective treatments and interventions through establishing basic knowledge and myself and my team have worked extensively in both adolescent Schizophrenia and Autism Spectrum Disorders. The lab also has a very extensive history of investigations into the neurophysiology of both basic and complex auditory processing, from investigations of the fundamental mechanisms of frequency representation all the way to high-level speech processing.

 

Selected Publications

2011 & “In Press”

  

Bell, R.P., Foxe, J.J., Nierenberg, J., Hoptman, M.J., Garavan, H.  White Matter Integrity as a Function of Abstinence Duration in Former Cocaine-Dependent Individuals. Drug and Alcohol Dependence, 2011, 114(2-3): 159-168.

  

Butler, J.S., Molholm, S., Fiebelkorn, I.C., Mercier, M.R., Schwartz, T.H., and Foxe, J.J. Common or redundant neural circuits for duration processing across audition and touch.  Journal of Neuroscience, 2011, 31(9): 3400-3406.

  

Krakowski, A., Ross, L.A., Sehatpour, P., Snyder, A.C., Kelly, S.P., and Foxe, J.J. The neurophysiology of human biological motion processing: A high-density electrical mapping study. Neuroimage, 2011, 56(1): 373-383.

  

Brandwein, A.B., Foxe, J.J., Russo, N., Altschuler, T., Gomes, H., Molholm, S. The development of audiovisual multisensory integration across childhood and early adolescence: A high-density electrical mapping study. Cerebral Cortex, 2011, 21(5): 1042-1055.  

  

Foxe, J.J., Yeap, S., Kelly, S.P., Snyder, A.C., Thakore, J.H., Molholm, S. The N1 auditory evoked potential component as an endophenotype for schizophrenia: High-density electrical mapping in clinically unaffected first-degree relatives, first-episode and chronic schizophrenia patients. European Archives of Psychiatry and Clinical Neuroscience, in press.

  

 Ross, L.A., Molholm, S., Blanco, D., Gomez-Ramirez, M., Saint-Amour, D., and Foxe, J.J.  The development of multisensory speech perception continues into the late childhood years. European Journal of Neuroscience, in press.

  

 Fiebelkorn, I.C., Foxe, J.J., Butler, J.S., and Molholm, S. Auditory Facilitation of Visual-Target Detection Persists Regardless of Retinal Eccentricity and Despite Wide Audiovisual Misalignments. Experimental Brain Research, in press.

  

 Senkowksi, D., Saint-Amour, D., Höfle, M., Foxe, J.J.  Multisensory Interactions in Early Evoked Brain Activity Follow the Principle of Inverse Effectiveness. Neuroimage, in press.

  

 O’Donoghue, T., Morris, D.W., Fahey, C., Da Costa, A., Foxe, J.J., Hoerold, D., Corvin, A., Gill, M., Donohoe, G.  A NOS1 variant previously associated with schizophrenia risk and cognitive deficits influences early sensory processing: A high density EEG study. Human Brain Mapping, in press.

 

 Banerjee, S., Molholm, S., Snyder, A.C., and Foxe, J.J. Oscillatory alpha-band mechanisms and the deployment of spatial attention to anticipated auditory and visual target locations: Supramodal or sensory-specific control mechanisms? Journal of Neuroscience, in press.

 

 Snyder, A.C., and Foxe, J.J. The countervailing forces of binding and selection in vision. Cortex, in press.

 

 Fiebelkorn, I.C., Foxe, J.J., Butler, J.S., Mercier, M.R., Snyder, A.C., Molholm, S.  Ready, Set, Reset: Stimulus-Locked Periodicity in Behavioral Performance Demonstrates the Consequences of Cross-sensory Phase Reset. Journal of Neuroscience, in press.

 

 Leavitt, V.M., Molholm, S., Gomez-Ramirez, M., and Foxe, J.J. “What” and “Where” in auditory sensory processing: A high-density electrical mapping study of distinct neural processes underlying sound object recognition and sound localization. Frontiers in Integrative Neuroscience, in press.

 

 

2010

 

 Fiebelkorn, I.C., Foxe, J.J., and Molholm, S. Dual mechanisms for the cross-sensory spread of attention: How much do learned associations matter? Cerebral Cortex, 2010, 20: 109-120.

  

 Lalor, E.C., and Foxe, J.J. Neural responses to uninterrupted natural speech can be extracted with precise temporal resolution. European Journal of Neuroscience, 2010, 31: 189-193.

  

 Snyder, A.C., and Foxe, J.J. Anticipatory attentional suppression of visual features indexed by oscillatory alpha-band power increases: a high-density electrical mapping study. Journal of Neuroscience, 2010, 30(11): 4024-4032.

  

 Keyes, H., Brady, N., Reilly, R.B., and Foxe, J.J. My face or yours? Event-related potential correlates of self-face processing. Brain and Cognition, 2010, 72(2): 244-254.

  

 Simões-Franklin, C., Hester, R., Shpaner, M., Foxe, J.J., and Garavan, H. Executive Function and Error Detection: The Effect of Motivation on Cingulate and Ventral Striatum Activity. Human Brain Mapping, 2010, 31(3): 458-469.

  

 Frey, H-P., Kelly, S.P., Lalor, E.C. and Foxe, J.J. Early spatial attentional modulation of inputs to the fovea. Journal of Neuroscience, 2010, 30(13): 4547-4551. 

  

 Kelly, S.P., Foxe, J.J., Newman, G., Edelman, J.A. Prepare for Conflict: EEG correlates of the anticipation of target competition during overt and covert shifts of visual attention. European Journal of Neuroscience, 2010, 31: 1690-1700.

  

 Fiebelkorn, I.C., Foxe, J.J., Schwartz, T.H., and Molholm, S. Staying within the lines: the formation of visuospatial boundaries influences multisensory feature integration. European Journal of Neuroscience, 2010, 31: 1737-1743.

 

 Sehatpour, P., Dias, E.C., Butler, P.D., Revheim, N., Guilfoyle, D.N., Foxe, J.J., Javitt, D.C. Impaired Visual Object Processing Across an Occipital-Frontal-Hippocampal Brain Network in Schizophrenia: An integrated neuro-imaging study. Archives of General Psychiatry, 2010, 67(8): 772-782.

 

 Leitman, D.I., Sehatpour, P., Higgins, B.A., Foxe, J.J., Silipo, G., Javitt, D.C. Sensory deficits and distributed hierarchical dysfunction in schizophrenia. American Journal of Psychiatry, 2010, 167(7): 818-827.

 

 Lucan, J.N., Foxe, J.J., Gomez-Ramirez, M., Sathian, K., and Molholm, S. Tactile shape discrimination recruits human lateral occipital complex during early perceptual processing. Human Brain Mapping, 2010, 31(11): 1813-1821.

 

Katz, R., De Sanctis, P., Mahoney, J.R., Sehatpour, P., Murphy, C., Gomez-Ramirez, M., Alexopoulos, G.S., and Foxe, J.J. Cognitive Control in Late-Life Depression: Response inhibition deficits and dysfunction of the Anterior Cingulate Cortex. American Journal of Geriatric Psychiatry, 2010, 18(11): 1017-1025. 

 

 Russo, N., Foxe, J.J., Brandwein, A., Altschuler, T., Gomes, H., Molholm, S. Multisensory processing in children with autism: high-density electrical mapping of auditory-somatosensory integration. Autism Research, 2010, 3(5): 253-267.

 

 

2009

 

Lalor, E.C., and Foxe, J.J. Visual evoked spread spectrum analysis (VESPA) responses to stimuli biased towards magnocellular and parvocellular pathways. Vision Research, 2009, 49: 127-133.

 

Fassbender, C., Hester, R., Murphy, K., Foxe, J.J., Foxe, D.M., and Garavan, H. Prefrontal and midline interactions mediating behavioural control. European Journal of Neuroscience, 2009, 29(1): 181-187.

 

Wylie, G.R., Murray, M.M., Javitt, D.C. and Foxe, J.J. Distinct neurophysiological mechanisms mediate mixing costs and switch costs. Journal of Cognitive Neuroscience, 2009, 21(1): 105-118.

 

O’Connell, R.G., Dockree, P.M., Bellgrove, M.A., Turin, A., Ward, S., Foxe, J.J., & Robertson, I.H. Two types of action error: electrophysiological evidence for separable inhibitory and sustained attention neural mechanisms producing error on Go/No-go tasks. Journal of Cognitive Neuroscience, 2009, 21(1): 93-104.

 

O’Connell, R., Bellgrove, M.A., Dockree, P.M., Lau, A., Hester, R., Garavan, H., Fitzgerald, M., Foxe, J.J., and Robertson, I.H. The neural correlates of deficient error awareness in attention-deficit hyperactivity disorder (ADHD). Neuropsychologia, 2009, 47(4): 1149-1159.

 

Ma, W.J., Zhou, X., Ross, L.A., Foxe, J.J. and Parra, L. Lip-reading aids word recognition most in moderate noise: a Bayesian explanation using high-dimensional feature space. PLoS ONE, 2009, 4(3): e4638.

 

Sperdin, H.F., Cappe, C., Foxe, J.J., & Murray, M.M. Early, low-level auditory-somatosensory multisensory interactions impact reaction time speed. Frontiers in Integrative Neuroscience, 2009, 3: Article 2.

 

De Sanctis, P., Molholm, S., Shpaner, M., Ritter, W., and Foxe, J.J. Right hemispheric contributions to fine auditory temporal discriminations: High-density electrical mapping of the duration mismatch negativity (MMN). Frontiers in Integrative Neuroscience, 2009, 3: Article 5.

 

O'Connell, R., Dockree, P.M., Robertson, I.H., Bellgrove, M.A., Foxe, J.J., Kelly, S.P. Uncovering the Neural Signature of Lapsing Attention: electrophysiological signals predict errors up to 20 s before they occur. Journal of Neuroscience, 2009, 29(26): 8604-8611.

 

Lalor, E.C., Power, A.J., Reilly, R.B. and Foxe, J.J. Resolving precise temporal processing properties of the auditory system using continuous stimuli. Journal of Neurophysiology, 2009, 102: 349–359.

 

Gomez-Ramirez, M., Kelly, S.P., Montesi, J.L., and Foxe, J.J. The effects of L-theanine on alpha-band oscillatory brain activity during a visuo-spatial attention task. Brain Topography, 2009, 22: 44-51.

 

Leitman, D.I., Foxe, J.J., Sehatpour, P., Shpaner, M., Javitt, D.C. Mismatch negativity (MMN) to tonal contours suggests preattentive perception of prosodic content. Brain Imaging and Behavior, 2009, 3(3): 284-291.

 

Yeap, S., Kelly, S.P., Reilly, R.B., Thakore, J.H., and Foxe, J.J. Visual sensory processing dysfunction as a common endophenotype for Bipolar Disorder and Schizophrenia. Journal of Psychiatry & Neuroscience, 2009, 34(6): 459-464.

 

Kemner, C., Foxe, J.J., Tankink, J.E., Kahn, R.S., and Lamme, V.A.F. Abnormal timing of visual feedback processing in young adults with Schizophrenia. Neuropsychologia, 2009, 47(14): 3105-3110.

 

De Sanctis, P., Gomez-Ramirez, M., Sehatpour, P., Wylie, G.R. and Foxe, J.J. Preserved executive function in high-performing elderly is driven by large-scale enhancement of prefrontal cortical mechanisms. Human Brain Mapping, 2009, 30(12): 4198-4214.

 

Shpaner, M., Murray, M.M., and Foxe, J.J. Early processing in human LOC is highly responsive to illusory contours but not to salient regions. European Journal of Neuroscience, 2009, 30(10): 2018-2028.

 

Kelly, S.P., Gomez-Ramirez, M., & Foxe, J.J.  The strength of anticipatory spatial biasing predicts target discrimination at attended locations: a high-density EEG study. European Journal of Neuroscience, 2009, 30(11): 2224-2234.

 

 

2008

 

 Lalor, E.C., Yeap, S., Reilly, R.B., Pearlmutter, B.A., and Foxe J.J. Dissecting the cellular contributions to early visual sensory processing deficits in schizophrenia using the VESPA evoked response. Schizophrenia Research, 2008, 98: 256-264.

 

 Donohoe, G., Morris, D.W., De Sanctis, P., Magno, E., Montesi, J.L., Garavan, H.P., Robertson, I.H., Javitt, D.C., Gill, M., Corvin, A.P. and Foxe, J.J. Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia. Biological Psychiatry, 2008, 63: 484-489.

 

 Wylie, G.R., Foxe, J.J., Taylor, T.L. Forgetting as an Active Process: An fMRI Investigation of Item-Method-Directed Forgetting. Cerebral Cortex, 2008, 18: 670-682.

 

 De Sanctis, P., Ritter, W., Molholm, S., Kelly, S.P., and Foxe, J.J. Auditory Scene Analysis: The interaction of stimulation rate and frequency separation on preattentive grouping. European Journal of Neuroscience, 2008, 27: 1271-1276.

 

 Sehatpour, P., Molholm, S., Schwartz, T.H., Mahoney, J.R., Mehta, A.D., Javitt, D.C., Stanton, P.K., and Foxe, J.J. Long-range oscillatory coherence across a frontal-occipital-hippocampal brain network during visual object processing: A human intracranial study. Proceedings of the National Academy of Sciences USA, 2008, 105: 4399-4404.

 

 Moran, R.J., Reilly, R.B., Molholm, S., and Foxe, J.J. Changes in Effective Connectivity of Human Superior Parietal Lobule under Multisensory and Unisensory Stimulation. European Journal of Neuroscience, 2008; 27: 2303–2312.

 

 Dale, C.L., Simpson, G.V., Foxe, J.J., Luks, T.L., Worden, M.S. ERP correlates of anticipatory attention: spatial and non-spatial specificity and relation to subsequent selective attention. Experimental Brain Research, 2008, 188: 45-62.

 

 McCourt, M.E., Shpaner, M., Javitt, D.C., and Foxe, J.J. Hemispheric asymmetry and callosal integration of visuospatial attention in schizophrenia: A tachistoscopic line bisection study. Schizophrenia Research, 2008, 102: 189-196.

 

 Yeap, S., Kelly, S.P., Thakore, J.H., and Foxe, J.J. Visual Sensory Processing Deficits in First-Episode Patients with Schizophrenia. Schizophrenia Research, 2008, 102: 340-343.

 

Kelly, S.P., Gomez-Ramirez, M., Montesi, J.L., and Foxe, J.J. The effects of L-theanine and caffeine on oscillatory alpha-band activity and attention task performance. Journal of Nutrition, 2008, 138: 1572S-1577S.

 

De Sanctis, P., Katz, R., Alexopoulos, G.S., Wylie, G.R. and Foxe, J.J. Enhancement and bilateralization of early sensory processing in the ventral visual stream may be a feature of normal aging: A high-density electrical mapping study. Neurobiology of Aging, 2008, 29: 1576-1586.

 

Magno, E., Yeap, S., Thakore, J.H., Garavan, H., De Sanctis, P., and Foxe, J.J.  Are Auditory-Evoked Frequency and Duration Mismatch Negativity (MMN) Deficits Endophenotypic for Schizophrenia?  High-Density Electrical Mapping in Clinically Unaffected First-Degree Relatives, First-Episode Psychosis and Chronic Schizophrenia. Biological Psychiatry, 2008, 64: 385-391.

 

Yeap, S., Kelly, S.P., Sehatpour, P., Magno, E., Garavan, H., Thakore, J.H., and Foxe, J.J. Visual sensory processing deficits in Schizophrenia and their relationship to disease state.  European Archives of Psychiatry and Clinical Neuroscience, 2008, 258: 305-316.

 

Foxe, J.J., Strugstad, E.C., Sehatpour, P., Molholm, S., Pasieka, W., Schroeder, C.E., McCourt, M.E. Parvocellular and Magnocellular contributions to the initial generators of the visual evoked potential: High-density electrical mapping of the “C1” component. Brain Topography, 2008, 12: 10-21.

 

Kelly, S.P., Gomez-Ramirez, M., & Foxe, J.J. Spatial attention modulates initial afferent activity in human primary visual cortex. Cerebral Cortex, 2008, 18: 2629-2636.

 

Senkowski, D., Schneider, T.R., Foxe, J.J. and Engel, A.K. Cross-modal binding by coherence of neural signals: new vistas on multisensory processing. Trends in Neuroscience, 2008, 31(8): 401-409.

 

Senkowski, D., Saint-Amour, D., Gruber, T., and Foxe, J.J. Look who’s talking: The deployment of visuo-spatial attention during multisensory speech processing under noisy environmental conditions, Neuroimage, 2008, 43(2): 379-387.

 

Barnett, K.J., Foxe, J.J., Molholm, S., Kelly, S.P., Shalgi, S., Mitchell, K.J., Newell, F.N. Differences in early sensory-perceptual processing in synesthesia: a visual evoked potentials study. Neuroimage, 2008, 43: 605-613.

 

 

2007

 

Saint-Amour, D., De Sanctis, P., Molholm, S., Ritter, W., and Foxe, J.J. Seeing Voices: High-density electrical mapping and source-analysis of the multisensory mismatch negativity evoked during the McGurk illusion. Neuropsychologia, 2007, 45: 587-597.

 

Butler, P.D., Martinez, A., Foxe, J.J., Kim, D., Silipo, G., Mahoney, J., Shpaner, M., Jalbrikowski, M., Javitt, D.C. Subcortical Visual Dysfunction In Schizophrenia Drives Secondary Cortical Impairments. Brain, 2007, 130: 417-430.

 

Gomez-Ramirez, M., Higgins, B.A., Rycroft, J.A., Owen, G.N., Mahoney, J., Shpaner, M. and Foxe, J.J. The deployment of Intersensory Selective Attention: A high-density electrical mapping study of the effects of theanine. Clinical Neuropharmacology, 2007, 30: 25-38.

 

Alexopoulos, G.S., Murphy, C., Gunning-Dixon, F.M., Kalayam, B., Katz, R., Kanellopoulos, D., Etwaroo, G.R., Klimstra, S. and Foxe, J.J. Event-related potentials in an affective Go/Nogo task and remission of geriatric depression. Neuroreport, 2007, 18: 217-221. [Cover article]

 

Senkowski, D., Gomez-Ramirez, M., Lakatos, P., Wylie, G.R., Molholm, S., Schroeder, C.E. and Foxe, J.J. Multisensory processing and oscillatory activity: analyzing non-linear electrophysiological measures in humans and simians. Experimental Brain Research, 2007, 177: 184-195.

 

Dockree, P.M., Kelly, S.P., Foxe, J.J., Reilly, R.B., Robertson, I.H. Optimal sustained attention is regulated by the spectral content of background EEG activity: Greater ongoing tonic alpha (~10Hz) power supports successful phasic goal activation. European Journal of Neuroscience, 2007, 25: 900-907. [Cover article]

 

Leitman, D.L., Hoptman, M., Foxe, J.J., Wylie, G.R., Nierenberg, J., Pasternak, R., Jalbrzikowski, M., Javitt, D.C. The neural substrates of impaired prosodic detection in schizophrenia and its sensorial antecedents. American Journal of Psychiatry, 2007, 164: 474-482.

 

Ross, L.A., Saint-Amour, D., Leavitt, V., Javitt, D.C., and Foxe, J.J. Do you see what I’m saying? Optimal Visual Enhancement of Speech Comprehension in Noisy Environments. Cerebral Cortex, 2007, 17: 1147-1153.

 

 O’Connell, R., Dockree, P.M., Bellgrove, M.A., Hester, R., Garavan, H., Robertson, I.H. and Foxe, J.J. The role of Cingulate Cortex in the detection of errors with and without awareness: A high-density electrical mapping study. European Journal of Neuroscience, 2007, 25: 2571-2579. 

 

 Senkowski, D. Saint-Amour, D., Kelly, S.P and Foxe, J.J. Multisensory processing of naturalistic objects in motion: A high-density electrical mapping and source estimation study. Neuroimage, 2007, 36: 877-888.

 

 Molholm, S., Martinez, A., Shpaner, M., Foxe, J.J. Object-Based Attention is Multisensory:  Co-activation of an Object’s Representations in Ignored Sensory Modalities. European Journal of Neuroscience, 2007, 26: 499-509.

 

 Martinez, A., Ramanathan, D.S., Foxe, J.J., Javitt, D.C., Hillyard, S.A. The role of spatial attention in the selection of real and illusory objects. Journal of Neuroscience, 2007, 27: 7963-7973.

 

 Leavitt, V.M., Molholm, S., Ritter, W., Shpaner, M., and Foxe, J.J. Auditory processing in schizophrenia during the middle latency period (10-50 milliseconds): High-density electrical mapping and source-analysis reveal subcortical antecedents to early cortical deficits. Journal of Psychiatry & Neuroscience, 2007, 32: 339-353.

 

 Hester , R., Barre, N., Mattingly, J.B., Foxe, J.J. and Garavan, H. Avoiding another mistake: Error and post-error neural activity associated with adaptive post-error behaviour change. Cognitive, Affective and Behavioural Neuroscience, 2007, 7: 317-326.

 

 Ross, L.A., Saint-Amour, D., Leavitt, V.M., Molholm, S., Javitt, D.C., and Foxe, J.J. Impaired Multisensory Processing in Schizophrenia: Deficits in Visual Enhancement of Speech Comprehension Under Noisy Environmental Conditions. Schizophrenia Research, 2007, 97: 173-183.

 

 Lalor, E.C., Kelly, S.P., Pearlmutter, B., Reilly, R.B., and Foxe, J.J. Isolating endogenous visuo-spatial attentional effects using the novel Visual Evoked Spread Spectrum Analysis (VESPA) technique. European Journal of Neuroscience, 2007, 26: 3536-3542.

 

 

2006

 

Sehatpour, P., Molholm, S., Javitt, D.C., and Foxe, J.J. Spatiotemporal Dynamics of Human Object Recognition Processing: An integrated high-density electrical mapping and functional imaging study of “closure” processes. Neuroimage, 2006, 29: 605-618.

 

Martinez, A., Teder-Sälajärvi, W., Vazquez, M., Molholm, S., Foxe, J.J., Javitt, D.C., Di Russo, F., Worden, M.S., and Hillyard, S.A. Objects are highlighted by spatial attention. Journal of Cognitive Neuroscience, 2006, 18: 298-310.

 

Wylie, G.R., Javitt, D.C., and Foxe, J.J. Jumping the Gun: Is Effective Preparation Contingent upon Anticipatory Activation in Task-relevant Neural Circuitry? Cerebral Cortex, 2006, 16: 394-404.

 

Kelly, S.P., Lalor, E.C., Reilly, R.B., and Foxe, J.J.  Alpha-Based Suppression Mechanisms Facilitate Sustained Visuo-Spatial Attention during Continuous Bilateral Stimulation. Journal of Neurophysiology, 2006, 95: 3844-3851.

 

Molholm, S., Sehatpour, P., Mehta, A.D., Shpaner, M., Gomez-Ramirez, M., Ortigue, S., Dyke, J.P., Schwartz, T.H., and Foxe, J.J. Audio-visual multisensory integration in superior parietal lobule revealed by human intracranial recordings. Journal of Neurophysiology, 2006, 96: 721-729.

 

Magno, E., Foxe, J.J., Molholm, S., Robertson, I.H., Garavan, H. The Anterior Cingulate and Error Avoidance. Journal of Neuroscience, 2006, 26: 4769-4773.

 

Kelly, A.M.C., Hester, R., Foxe, J.J., Shpaner, M., and Garavan, H. Flexible Cognitive Control: Effects of individual differences and brief practice on a complex cognitive task. Neuroimage, 2006, 31: 866-886.

 

Ritter, W., De Sanctis, P., Molholm, S., Javitt, D.C., and Foxe, J.J. Preattentively grouped tones do not elicit MMN with respect to each other. Psychophysiology, 2006, 43: 423-430.

 

Lalor, E.C. Pearlmutter, B.A., Reilly, R.B., McDarby, G., and Foxe, J.J. The VESPA: a Method for the Rapid Estimation of a Visual Evoked Potential. Neuroimage, 2006, 32: 1549-1561.

 

Dias. E.C., McGinnis, T., Smiley, J.F., Foxe, J.J., Schroeder, C.E. and Javitt, D.C. Activation of dorsolateral prefrontal and anterior cingulate cortices during performance of AX-CPT shown by intracranial recording in the monkey. Experimental Brain Research, 2006, 174: 279-291.

 

Simpson, G.V., Dale, C.L., Luks, T.L., Miller, W., Ritter, W., and Foxe, J.J. Rapid Targeting Followed by Sustained Deployment of Visual Spatial Attention. Neuroreport, 2006, 17: 1595-1599.

 

Senkowski, D., Molholm, S., Gomez-Ramirez, M., and Foxe, J.J. Oscillatory beta activity predicts response speed during a multisensory audiovisual reaction time task: A high-density electrical mapping study. Cerebral Cortex, 2006, 16: 1556-1565.

 

Butler, P.D., Hoptman, M.J., Nierenberg, J., Foxe, J.J., Javitt, D.C., Lim, K.O. Visual white matter integrity in schizophrenia. American Journal of Psychiatry, 2006, 163: 2011-2013.

 

Fassbender, C., Foxe, J.J., Garavan, H. Mapping the functional anatomy of task preparation: priming task-appropriate brain networks. Human Brain Mapping, 2006, 27: 819-827.

 

Yeap, S., Kelly, S.P., Sehatpour, P., Magno, E., Javitt, D.C., Garavan, H., Thakore, J.H., and Foxe, J.J.  Early Visual Sensory Deficits as Endophenotypes for Schizophrenia: High-Density Electrical Mapping in Clinically Unaffected First-Degree Relatives. Archives of General Psychiatry, 2006, 63: 1180-1188.

 

Murray, M.M., Imber, M.L., Javitt, D.C., and Foxe, J.J. Boundary Completion is Automatic and Dissociable from Shape Discrimination. Journal of Neuroscience, 2006, 26: 12043-12054.

 

Kelly, A.M.C., Foxe, J.J., and Garavan, H.  Patterns of normal brain plasticity following practice and their implications for neurorehabilitation. Archives of Physical Medicine and Rehabilitation, 2006, 87, 20-29.

 

 

2005

 

Senkowski, D., Rottger, S., Grimm, S., Foxe, J.J., Herrmann, C.S. Kanizsa subjective figures capture visual spatial attention: Evidence from electrophysiological and behavioral data. Neuropsychologia, 2005, 43: 872-886.

 

Foxe, J.J., and Schroeder, C.E. The case for feedforward multisensory convergence during early cortical processing. Neuroreport, 2005, 16: 419-423.

 

Molholm, S., Martinez, A.G., Ritter, W., Javitt, D.C., and Foxe, J.J. The neural circuitry of pre-attentive auditory change-detection: an fMRI study of pitch and duration mismatch negativity generators. Cerebral Cortex, 2005, 15: 545-551.

 

Roche, R.A.P., Garavan, H., Foxe, J.J. and O’Mara, S.M. Individual differences discriminate event-related potentials but not performance during response inhibition. Experimental Brain Research, 2005, 160: 60-70.

 

Murray, M.M., Molholm, S., Michel, C.M., Ritter, W., Heslenfeld, D.J., Schroeder, C.E., Javitt, D.C., and Foxe, J.J.  Grabbing your ear: Rapid auditory-somatosensory multisensory interactions in low-level sensory cortices are not constrained by stimulus alignment Cerebral Cortex, 2005, 15: 963-974.

 

Leitman, D.I., Foxe, J.J., Butler, P.D., Saperstein, A., Javitt, D.C. Sensory Contributions to impaired prosodic processing in Schizophrenia. Biological Psychiatry, 2005, 58: 56-61.

 

Kelly, S.P., Lalor, E., Reilly, R.B., and Foxe, J.J. Visual Spatial Attention Tracking using High-Density SSVEP Data for Independent Brain-Computer Communication. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2005, 13: 172-17.

 

Murray, M.M., Foxe, J.J., Wylie, G.R. The brain uses multisensory memories, discriminating without awareness. Neuroimage, 2005, 27: 473-478.

 

Dockree, P.M., Kelly, S.P., Robertson, I.H., Reilly, R.B., and Foxe, J.J. Neurophysiological markers of alert responding during goal-directed behaviour: a high-density electrical mapping study. Neuroimage, 2005, 27: 587-601. 

 

Schroeder, C.E., and Foxe, J.J. Multisensory contributions to low-level, “Unisensory” processing. Current Opinions in Neurobiology, 2005, 15(4): 454-458.

 

Hester, R., Foxe, J.J., Molholm, S., Shpaner, M., and Garavan, H. Neural correlates of error detection with and without awareness. Neuroimage, 2005, 27: 602-608.

 

Saint-Amour, D., Saron, C.D., Schroeder, C.E., and Foxe, J.J. Can whole brain nerve conduction velocity be derived from surface-recorded visual evoked potentials?: A comment on Reed, Vernon and Johnson (2004). Neuropsychologia, 2005, 43: 1838-1844.

 

Foxe, J.J., Simpson, G.V., Ahlfors, S.P., Saron, C.D. Biasing the brain's attentional set: I. Cue driven deployments of intersensory selective attention. Experimental Brain Research, 2005, 166: 370-392.

 

Foxe, J.J., Simpson, G.V. Biasing the brain's attentional set: II. Effects of selective intersensory attentional deployments on subsequent sensory processing. Experimental Brain Research, 2005, 166: 393-401.

 

Gonzalez Andino, S.L., Murray. M.M., Foxe, J.J., Grave de Peralta Menendez, R.  How single-trial electrical neuroimaging contributes to multisensory research? Experimental Brain Research, 2005, 166: 298-304.

 

Foxe, J.J., Murray, M.M., Javitt, D.C. Filling-in in Schizophrenia: a high-density electrical mapping and source-analysis investigation of illusory contour processing. Cerebral Cortex, 2005, 15: 1914-1927.

 

 

2004

 

McCourt, M.E., and Foxe, J.J.  Brightening Prospects for “Early” Cortical Coding of Perceived Luminance. Neuroreport, 2004, 15: 49-56. [Cover article]

 

Wylie, G.R., Javitt, D.C., and Foxe, J.J.  Don’t think of a white bear: an fMRI investigation of the effects of sequential instructional sets on cortical activity in a task-switching paradigm. Human Brain Mapping, 2004, 21: 279-297. [Cover article]

 

Molholm, S., Ritter, W., Javitt, D.C. and Foxe, J.J. Multisensory visual-auditory object recognition in humans: A high-density electrical mapping study. Cerebral Cortex, 2004, 14: 452-465.

 

Wylie, G.R., Javitt, D.C., and Foxe, J.J.  The role of response requirements in task switching: dissolving the residue. Neuroreport, 2004, 15: 1079-1087.

 

Roche, R.A.P., Dockree, P.M., Garavan, H., Foxe, J.J., Robertson, I.H., O’Mara, S.M. EEG alpha power changes reflect response inhibition deficits after traumatic brain injury (TBI). Neuroscience Letters, 2004, 362: 1-5.

 

Hester, R., Murphy, K., Foxe, J.J., Foxe, D.M., Javitt, D.C., and Garavan, H.  Predicting Success: Patterns of cortical activation and deactivation prior to response inhibition. Journal of Cognitive Neuroscience, 2004, 16: 776-785.

 

Kelly, A.M.C., Hester, R., Murphy, K., Javitt, D.C., Foxe, J.J., and Garavan, H. Prefrontal-subcortical dissociations underlying inhibitory control revealed by event-related fMRI. European Journal of Neuroscience, 2004, 19: 3105-3112.

 

Schroeder, C.E., Molholm, S., Lakatos, P., Ritter, W. and Foxe, J.J.  Human-Simian correspondence in the early cortical processing of multisensory cues. Cognitive Processing, 2004, 5(3): 140-151.

 

Fassbender, C., Murphy, K., Foxe, J.J., Wylie, G.R., Javitt, D.C., Robertson, I.H., and Garavan, H. A Topography of Executive Functions revealed by functional Magnetic Resonance Imaging. Cognitive Brain Research, 2004, 20: 132-143.

Murray, M.M., Foxe D.M., Javitt, D.C. and Foxe, J.J. Setting boundaries: Brain dynamics of modal and amodal illusory contour completion in humans. Journal of Neuroscience, 2004, 24: 6898-6903.

 

 

2003

Wylie, G.R., Javitt, D.C., and Foxe, J.J. Cognitive control processes during an anticipated switch of task. European Journal of Neuroscience, 2003, 17: 667-672.

 

Foxe, J.J., McCourt, M.E., Javitt, D.C. Right hemisphere control of visuo-spatial attention: 'Line-bisection' judgments evaluated with high-density electrical mapping and source-analysis. NeuroImage, 2003, 19: 710-726.

 

Dias, E.C., Foxe, J.J., Javitt D.C.  Changing Plans: a High Density Electrical Mapping Study of Cortical Control. Cerebral Cortex, 2003, 13: 701-715.

 

Worden, M.S. and Foxe J.J. The dynamics of the spread of selective visual attention. Proceedings of the National Academy of Science, USA, 2003, 100: 11933-11935.

 

Wylie, G.R., Javitt, D.C., and Foxe, J.J.  Task-switching: a High Density Electrical Mapping Study. NeuroImage, 2003, 20: 2322-2342.

 

 

2002

Foxe, J.J. and Simpson, G.V. Timecourse of activation flow from V1 to frontal cortex in humans: A framework for defining "early" visual processing. Experimental Brain Research, 2002, 142: 139-150.

 

Ritter, W., Sussman, E., Molholm, S., and Foxe, J.J. Memory reactivation or reinstatement and the mismatch negativity. Psychophysiology, 2002, 39: 158-165.

 

Molholm, S., Ritter, W., Murray, M.M., Javitt, D.C., Schroeder, C.E., Foxe, J.J. Multisensory auditory-visual interactions during early sensory processing in humans: A high-density electrical mapping study. Cognitive Brain Research, 2002, 14: 121-134. [Cover article]

 

Schroeder, C.E., and Foxe, J.J. The timing and Laminar Profile of Converging Inputs to Multisensory Areas of the Macaque Neocortex. Cognitive Brain Research, 2002, 14: 195-207.

 

Murray, M.M., Wylie, G.R., Higgins, B.A., Javitt, D.C., Schroeder, C.E. and Foxe, J.J.  A Spatio-Temporal Analysis of Illusory Contour Processing: Combined High-Density Electrical Mapping, Source Analysis, and Functional Magnetic Resonance Imaging. Journal of Neuroscience, 2002, 22: 5055-5073.

 

Foxe, J.J., Wylie, G.R., Martinez, A.G., Schroeder, C.E., Javitt, D.C., Guilfoyle, D., Murray, M.M. Auditory-Somatosensory Multisensory Processing in Auditory Association Cortex: An fMRI Study.  Journal of Neurophysiology, 2002, 88: 540-543.

 

Doniger, G.M., Foxe, J.J., Murray, M.M., Higgins, B.H., Javitt, D.C. Perceptual Closure Deficits in Schizophrenia: A High-Density Electrical Mapping Study. Archives of General Psychiatry, 2002, 59: 1011-1020.

 

 

2001

Doniger, G.M., Foxe, J.J., Murray, M.M., Higgins, B.A., Schroeder, C.E., and Javitt, D.C. Visual perceptual learning in human object recognition areas: A repetition priming study using high-density electrical mapping. NeuroImage, 2001, 13: 305-313.

 

Murray, M.M., Foxe, J.J., Higgins, B.A., Javitt, D.C. and Schroeder, C.E. Visuo-spatial neural response interactions in early cortical processing during a simple reaction time task: A high-density electrical mapping study. Neuropsychologia, 2001, 39(8): 828-844. 

  

Fu, K.G., Foxe, J.J., Murray, M.M., Higgins, B.A., Javitt, D.C., Schroeder, C.E., Attention-dependent suppression of distracter visual input can be cross-modally cued as indexed by anticipatory parieto-occipital alpha-band oscillations. Cognitive Brain Research, 2001, 12: 145-152. [Cover article] 

 

Saron, C.D., Schroeder, C.E., Foxe, J.J., and Vaughan, H.G. Jr. Visual activation of frontal cortex: segregation from occipital activity. Cognitive Brain Research, 2001, 12: 75-88. 

 

Foxe, J.J., Doniger, G.M., and Javitt, D.C. Visual processing deficits in Schizophrenia: Impaired P1 generation revealed by high-density electrical mapping. Neuroreport, 2001, 12(17): 3815-3820.  

 

Schroeder, C.E., Mehta, A.D. and Foxe, J.J. Determinants and mechanisms of attentional modulation of neural processing. Frontiers in Bioscience, 2001, 6: D672-684.

 

  

2000

Worden, M.S., Foxe, J.J., Wang, N., and Simpson, G.V. Anticipatory biasing of visuospatial attention indexed by retinotopically specific alpha-band EEG increases over occipital cortex. Journal of Neuroscience, 2000, 20: RC63 (1-6).

 

Doniger, G.M., Foxe, J.J., Murray, M.M., Higgins, B.A., Schroeder, C.E., and Javitt, D.C. Activation timecourse of ventral visual stream object-recognition areas: high density electrical mapping of perceptual closure processes. Journal of Cognitive Neuroscience, 2000, 12(4): 615-621.

 

Foxe, J.J., Morocz, I.A., Higgins, B.A., Murray, M.A., Javitt, D.C., Schroeder, C.E. Multisensory Auditory-Somatosensory Interactions in Early Cortical Processing.  Cognitive Brain Research, 2000, 10: 77-83.

 

 

1993-1998

 

Foxe, J.J. and Stapells, D.R. Normal infant and adult auditory brainstem responses to bone-conducted tones. Audiology, 1993, 32: 95-109.

 

Simpson, G.V., Pfleiger, M.E., Foxe, J.J., Ahlfors, S.P., Vaughan, H.G. Jnr., Hrabe, J., Ilmoniemi, R.J., & Lantos, G. Dynamic neuroimaging of brain function. Journal of Clinical Neurophysiology, 1995, 12(5): 1-18.

 

Simpson, G.V., Foxe, J.J., Vaughan, H.G., Jr. Mehta, A.D., and Schroeder, C.E. Integration of electrophysiological source analyses, MRI and animal models in the study of visual processing and attention. EEG and clin. Neurophysiology, 1995, Suppl. 44: pp.76-92.

 

Foxe, J.J., Simpson, G.V., and Ahlfors, S.P. Cued shifts of intermodal attention: Parieto-occipital ~10 Hz activity reflects anticipatory state of visual attention mechanisms. Neuroreport, 1998, 9(17): 3929-3933. [Cover article]

  

 

 

BOOK CHAPTERS, COMMENTARIES, PROCEEDINGS & OTHER EPHEMERA:

 

Saron, C. D., Foxe, J. J., Simpson, G. V. and Vaughan, H. G., Jr. Electrophysiological indices of interhemispheric visuomotor interaction [translated to Italian]. In: Proverbio, M. and Zani A.(Eds.), Psicofisiologia Cognitiva. Le basi neuro-funzionali delle mente umana [Cognitive Psychophysiology. The neuro-functional substrates of human mind], Carocci Editore: Roma, 2000.

 

Foxe, J.J., & Schroeder, C.E.  Preface: Multisensory Processing. Cognitive Brain Research, 2002, 14: 1-2.

 

Saron, C.D., Foxe J.J., Schroeder, C.E., and Vaughan, H.G. Jnr.  Complexities of interhemispheric communication in sensory-motor tasks revealed by high-density event-related potential mapping. In: Hugdahl & Davidson (Eds.) The Asymmetrical Brain, MIT Press, Cambridge Massachusetts, 2003, pp. 341-408.

 

Saron, C.D., Foxe J.J., Simpson, G.V. and Vaughan, H.G. Jnr., Spatiotemporal electrophysiology of interhemispheric integration: Relations with behaviour. In: E. Zeidel, and M. Iacaboni (Eds.) The Parallel Brain: The Cognitive Neuroscience of the Corpus Callosum, MIT Press, New York, 2003, pp. 171-219.

 

Schroeder, C.E. and Foxe, J.J.  Multisensory convergence in early cortical processing. In: G.A. Calvert, C. Spence & B.E. Stein (Eds.) The Handbook of Multisensory Processes, MIT Press, Cambridge Massachusetts, 2004, pp. 295-309.

 

Molholm, S. and Foxe, J.J. Look ‘hear’, primary auditory cortex is active during lip-reading. Neuroreport, 2005, 6: 123-124.

 

Soto-Faraco, S., Foxe, J.J., Wallace, M.T. Multisensory Processes. Experimental Brain Research, 2005, 166: 287-288.

 

Kelly, S.P., Lalor, E.C., Reilly, R.B., and Foxe, J.J. Independent brain computer interface control using visual spatial attention-dependent modulations of parieto-occipital alpha. 2nd International IEEE EMBS Conference on Neural Engineering, 2005, 2005: 667-670

 

Lalor, E.C., Reilly, R.B., Pearlmutter, B.A., and Foxe, J.J. A Spectrum of Colors: Investigating the Temporal Frequency Characteristics of the Human Visual System using a System Identification Approach. Conf Proc IEEE Eng Med Biol Soc. 2006, 1: 3720-3723.

 

Butler, P.D., Martinez, A., Foxe, J.J., Kim, D., Silipo, G., Mahoney, J., Shpaner, M., Jalbrikowski, M., Javitt, D.C.  Reply: A few remarks on assessing magnocellular sensitivity in patients with schizophrenia. Brain, 2007, 130(11): e84.

 

Lalor, E.C., Pearlmutter, B.A., and Foxe, J.J. Reverse Correlation and the VESPA Method. In: T.C. Handy (Ed) Brain Signal Analysis: Advances in Neuroelectric and Neuromagnetic Methods., MIT Press: Cambridge, Massachusetts, 2009, pp. 1-19.

 

Foxe, J.J. Toward the end of a “principled” era in Multisensory Science. Brain Research, 2008, 1242: 1-3. [Cover article]

 

Shalgi, S., and Foxe, J.J. The neurophysiology of bi-directional synesthesia (Commentary on Gebuis et al.). European Journal of Neuroscience, 2009, 29(8): 1701-1702.

 

Foxe, J.J. Crossed Wires in the Brain: Multisensory Integration in Synaesthesia (Chapter 8).  In: R.A.P. Roche, and S. Commins (Eds.) Pioneering Studies in Cognitive Neuroscience. McGraw-Hill, 2009, pp. 115-120.

 

Foxe, J.J. Multisensory integration: frequency tuning of audio-tactile integration. Current Biology, 2009, 19(9): R373-375.

 

Foxe, J.J. and Molholm, S. Ten years at the Multisensory Forum: Musings on the evolution of a field. Brain Topography, 2009, 21: 149-154.

 

Lalor, E.C., and Foxe, J.J.  Reply to Skottun & Skoyles. On interpreting responses to low contrast stimuli in terms of magnocellular activity - A few remarks. Vision Research, 2010, 50(10): 991-994.

 

Molholm, S., and Foxe, J.J. Making sense of multisensory integration. European Journal of Neuroscience, 2010, 31: 1709-1712. [Cover article]

 

Foxe, J.J., Ross. L.A., Molholm, S. Multisensory integration deficits in schizophrenia. In: B.E. Stein (Ed.) The Handbook of Multisensory Processes, 2nd Edition, MIT Press, Cambridge Massachusetts, in press.

 

Foxe, J.J. The interface of multisensory processing and selective attention. In: B.E. Stein (Ed.) The Handbook of Multisensory Processes, 2nd Edition, MIT Press, Cambridge Massachusetts, in press.

 

Fiebelkorn, I.C., Foxe, J.J., Molholm, S. Attention and multisensory feature integration. In: B.E. Stein (Ed.) The Handbook of Multisensory Processes, 2nd Edition, MIT Press, Cambridge Massachusetts, in press.

 

Foxe, J.J., and Snyder, A.C. The role of alpha-band oscillations as a sensory suppression mechanism during selective attention. Frontiers in Perception Science, in press.

 

More Information About Dr. John Foxe

The Cognitive Neurophysiology Laboratory @ Einstein

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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Van Etten, Room 1C-3C
Bronx, NY 10461

Tel: 718.862.1822
Fax: 718.862.1807
john.foxe@einstein.yu.edu

 
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Media Coverage

MSNBC interviews Dr. John Foxe about the new CDC report that finds the rate of autism is now 1 in 68 U.S. children, up 30% from 1 in 88 in 2008.

Scientific American interviews Dr. John Foxe about Mobile Brain/Body Imaging, or MoBI. The mobile and wireless technology allows electroencephalographic (EEG) brain-wave detection while patients are moving, allowing scientists to study the brain in more natural settings.

More media coverage