Professor, Department of Medicine (Cardiology)
Professor, Department of Microbiology & Immunology
Edmond J. Safra/Republic National Bank of New York Chair in Cardiovascular Medicine
Dr Frangogiannis’ research explores the mechanisms of cardiac injury and repair. His laboratory has identified key molecular signals responsible for orchestrating the healing response in myocardial infarction. Research has focused on four main directions:
a) The role of chemokine-mediated pathways in cardiac injury and repair. Current research studies the significance of specific chemokine/chemokine receptor interactions in recruitment of monocyte and lymphocyte subsets with anti-inflammatory properties.
b) Signals involved in resolution of the inflammatory reaction and in containment of the fibrotic response following infarction. Dr Frangogiannis’ laboratory has identified endogenous molecular pathways preventing excessive inflammation and uncontrolled fibrosis following cardiac injury.
c) The role of the dynamic alterations in the composition of the extracellular matrix network in modulating inflammatory pathways and cellular behavior in the injured and remodeling heart.
d) The mechanisms involved in the pathogenesis of cardiac fibrosis in the cardiomyopathy associated with diabetes and obesity.
The goal of the Frangogiannis laboratory is to identify therapeutic targets for attenuation of adverse remodeling following cardiac injury, thus preventing the development of heart failure.
Selected recent publications:
M Bujak, G Ren, HJ Kweon, M Dobaczewski, A Reddy, G Taffet, XF Wang, and NG Frangogiannis. Essential Role of Smad3 in Infarct Healing and in the Pathogenesis of Cardiac Remodeling. Circulation 2007; 116:2127-38.
P Huebener, T Abou-Khamis, P Zymek, M Bujak, Ying X, K Chatila, S Haudek, G Thakker, and NG Frangogiannis, CD44 is critically involved in infarct healing by regulating the inflammatory and fibrotic response. J Immunol 2008; 180:2625-33.
M Bujak, HJ Kweon, K Chatila, N Li, G Taffet, and NG Frangogiannis. Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction. J Am Coll Cardiol 2008; 51:1384-92.
M Bujak, M Dobaczewski, K Chatila, L Mendoza, N Li, A Reddy, and NG Frangogiannis. Interleukin-1 type (IL-1RI) signaling critically regulates infarct healing and cardiac remodeling. Am J Pathol 2008; 173:57-67.
M Bujak, M Dobaczewski, C Gonzalez-Quesada, Y Xia, T Leucker, P Zymek, V Veeranna, A Tager, A Luster, and NG Frangogiannis. Induction of the CXC Chemokine Interferon-g-Inducible Protein (IP)-10 Regulates the Reparative Response Following Myocardial Infarction. Circ Res 2009; 105:973-83.
M Dobaczewski, Y Xia, M Bujak, C Gonzalez-Quesada, and NG Frangogiannis. CCR5 signaling suppresses inflammation and reduces adverse remodeling following myocardial infarction mediating recruitment of regulatory T cells. Am J Pathol 2010; 176: 2177-87.
M Dobaczewski, M Bujak, N Li, C Gonzalez-Quesada; LH Mendoza, XF Wang, and NG Frangogiannis. Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ Res 2010; 107 (3): 418-28.
M Dobaczewski, W Chen and NG Frangogiannis. Transforming Growth Factor (TGF)-beta signaling in cardiac remodeling. J Mol Cell Cardiol 2011; 51:600-606.
NG Frangogiannis. The SDF-1/CXCR4 axis in cardiac injury and repair. J Am Coll Cardiol 2011; 58: 2424-2426.
Y Xia, M Dobaczewski, C Gonzalez-Quesada, W Chen, A Biernacka, N Li, D Lee, and NG Frangogiannis. Endogenous Thrombospondin-1 protects the pressure-overloaded myocardium by modulating fibroblast phenotype and matrix metabolism. Hypertension 2011; 58: 902-911.
NG Frangogiannis. Regulation of the inflammatory response in cardiac repair. Circ Res 2012: 110: 159-173.
NG Frangogiannis. Matricellular proteins in cardiac adaptation and disease. Physiol Rev 2012; 92:635-688.
W Chen, A Saxena, N Li, J Sun, DW Lee, Q Tian, M Dobaczewski, and NG Frangogiannis. Endogenous IRAK-M attenuates post-infarction remodeling through effects on macrophages and fibroblasts. Arterioscl Thromb Vasc Biol 2012; 32:2598-608.
W Chen and NG Frangogiannis. Fibroblasts in post-infarction inflammation and cardiac repair. BBA Mol Basis Dis. 2013; 1833:945-53
P Christia, M Bujak, C Gonzalez-Quesada, W Chen, M Dobaczewski, A Reddy, and NG Frangogiannis. Systematic characterization of myocardial inflammation, repair and remodeling in a mouse model of reperfused myocardial infarction. J Histochem Cytochem 2013; 61:555-570.
P Christia, and NG Frangogiannis. Targeting inflammatory pathways in myocardial infarction. Eur J Clin Invest 2013; 43: 986-95.
P Kong, C Gonzalez-Quesada, N Li, M Cavalera, D-W Lee, and NG Frangogiannis. Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation. Am J Physiol Endocrinol Metab 2013; 305:E439-450.
P Kong, P Christia, A Saxena, Y Su, and NG Frangogiannis. Lack of specificity of Fibroblast Specific Protein (FSP)1 in cardiac remodeling and fibrosis. Am J Physiol Heart Circ Physiol 2013;305(9):H1363-72.
A Saxena, W Chen, Y Su, V Rai, OU Uche, N Li, and NG Frangogiannis. IL-1 induces proinflammatory leukocyte infiltration and regulates fibroblast phenotype in the infarcted myocardium. J Immunol 2013; 191(9):4838-48.
C Gonzalez-Quesada, M Cavalera, A Biernacka, P Kong, DW Lee, A Saxena, O Frunza, M Dobaczewski, AV Shinde, and NG Frangogiannis. Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix while promoting vascular rarefaction through angiopoietin-2 upregulation. Circ Res 2013; 113(12):1331-44.
P Kong, P Christia, and NG Frangogiannis. The pathogenesis of cardiac fibrosis. Cell Mol Life Sci 2014 ; 71: 549-574.
AV Shinde and NG Frangogiannis. Fibroblasts in myocardial infarction: a role in inflammation and repair. J Mol Cell Cardiol 2014; 70:74-82.
NG Frangogiannis. The inflammatory response in myocardial injury, repair and remodeling. Nat Rev Cardiol 2014; 11:255-265.
A Saxena, M Bujak, O Frunza, M Dobaczewski, C Gonzalez-Quesada, B Lu, C Gerard, and NG Frangogiannis. CXCR3-independent actions of the CXC chemokine CXCL10 in the infarcted myocardium and in isolated cardiac fibroblasts are mediated through proteoglycans. Cardiovasc Res 2014; 103:217-227.
M Cavalera, J Wang, and NG Frangogiannis. Obesity, metabolic dysfunction and cardiac fibrosis: pathophysiologic pathways, molecular mechanisms and therapeutic opportunities. Transl Res 2014; 164:323-335.
A Saxena, M Dobaczewski, V Rai, Z Haque, W Chen, N Li, and NG Frangogiannis. Regulatory T cells are recruited in the infarcted mouse myocardium and may modulate fibroblast phenotype and function. Am J Physiol Heart Circ Physiol 2014; 307(8):H1233-42.
NG Frangogiannis. The pathophysiology of myocardial infarction. Compr Physiol 2015; 5:1841-75.
AV Shinde and NG Frangogiannis. Mediators secreted by myeloid cells may protect and repair the infarcted myocardium Circ Res 2015; 117:10-12.
A Biernacka, M Cavalera, J Wang, I Russo, A Shinde, P Kong, C Gonzalez-Quesada, V Rai, M Dobaczewski, DW Lee, XF Wang, and NG Frangogiannis. Smad3 signaling promotes fibrosis, while preserving cardiac and aortic geometry in obese diabetic mice. Circ Heart Fail 2015; 8: 788-798.
A Saxena, AV Shinde, Z Haque, YJ Wu, W Chen, Y Su, and NG Frangogiannis. The role of Interleukin receptor associated kinase (IRAK)-M in regulation of myofibroblast phenotype in vitro, and in an experimental model of non-reperfused myocardial infarction. J Mol Cell Cardiol 2015; 89: 223-31.
NG Frangogiannis. The reparative function of cardiomyocytes in the infarcted myocardium Cell Metab 2015; 21: 797-798.
NG Frangogiannis. Emerging roles for macrophages in cardiac injury: cytoprotection, repair and regeneration J Clin Invest 2015; 125: 2927-30.
I Russo, and NG Frangogiannis. Diabetes-associated cardiac fibrosis: cellular effectors, molecular mechanisms and therapeutic opportunities. J Mol Cell Cardiol 2015; 90:84-93.
Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.
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