Faculty Profile

Dr. Neeraj K. Saini, Ph.D.

Neeraj K. Saini, Ph.D.

Associate, Department of Microbiology & Immunology

Selected Publications

Johnson AJ, Kennedy SC, Lindestam Arlehamn CS, Goldberg MF, Saini NK, Xu J, Paul S, Hegde SS, Blanchard JS, Chan J, Jacobs WR Jr, Sette A, Porcelli SA. Identification of Mycobacterial RplJ/L10 and RpsA/S1 Proteins as Novel Targets for CD4+ T Cells. Infect Immun. 2017 Mar 23;85(4),PMID: 28115505

Saini NK, Sinha R, Singh P, Sharma M, Pathak R, Rathor N, Varma-Basil M, Bose M. Mce4A protein of Mycobacterium tuberculosis induces pro inflammatory cytokine response leading to macrophage apoptosis in a TNF-α dependent manner. Microb Pathog. 2016 Aug 31; 100:43-50,PMID: 27592091.

Saini NK, Baena A, Ng TW, Venkataswamy MM, Kennedy SC, Kunnath-Velayudhan S, Carreño LJ, Xu J, Chan J, Larsen MH, Jacobs WR Jr, Porcelli SA. Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47. Nat Microbiol. 2016 Aug 15;1(9):16133, PMID: 27562263. 

Arora P, Kharkwal SS, Ng TW, Kunnath-Velayudhan S, Saini NK, Johndrow CT, Chang YT, Besra GS, Porcelli SA. "Endocytic pH regulates cell surface localization of glycolipid antigen loaded CD1d complexes". Chem Phys Lipids. 2016 Jan; 194:49-57, PMID: 26496152. 

Singh P, Sinha R, Tandon R, Tyagi G, Khatri P, Chandra Shekhar Reddy L, Saini NK, Pathak R, Varma-Basil M, Prasad AK, Bose M. Revisiting a protocol for extraction of mycobacterial lipids. Int J Mycobacteriol. 2014 Sep;3(3):168-72, PMID: 26786484.

Pasricha R, Saini NK, Rathor N, Pathak R, Sinha R, Varma-Basil M, Mishra K, Brahmachari V, Bose M. The Mycobacterium tuberculosis recombinant LprN protein of mce4 operon induces Th-1 type response deleterious to protection in mice. Pathog Dis. 2014 Dec;72(3):188-96. PMID: 24989028.

Chandolia A, Rathor N, Sharma M, Saini NK, Sinha R, Malhotra P, Brahmachari V,   Bose M. Functional analysis of mce4A gene of Mycobacterium tuberculosis H37Rv using antisense approach. Microbiol Res. 2014 Sep-Oct;169(9-10):780-7, PMID: 24556072.

Arora P, Baena A, Yu KO, Saini NK, Kharkwal SS, Goldberg MF, Kunnath-Velayudhan S, Carreño LJ, Venkataswamy MM, Kim J, Lazar-Molnar E, Lauvau G, Chang YT, Liu Z, Bittman R, Al-Shamkhani A, Cox LR, Jervis PJ, Veerapen N, Besra GS, Porcelli SA. A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens. Immunity. 2014 Jan 16;40(1), PMID: 24412610; PubMed Central PMCID: PMC3895174.

Rathor N, Chandolia A, Saini NK, Sinha R, Pathak R, Garima K, Singh S, Varma-Basil M, Bose M. An insight into the regulation of mce4 operon of Mycobacterium tuberculosis. Tuberculosis (Edinb). 2013 Jul;93(4):389-97, PMID: 23622789.

Baghel AS, Tandon R, Gupta G, Kumar A, Sharma RK, Aggarwal N, Kathuria A, Saini NK, Bose M, Prasad AK, Sharma SK, Nath M, Parmar VS, Raj HG. Characterization of protein acyltransferase function of recombinant purified GlnA1 from Mycobacterium tuberculosis: a moon lighting property. Microbiol Res. 2011 Dec 20;166(8):662-72. PMID: 21411303.

Pasricha R, Chandolia A, Ponnan P, Saini NK, Sharma S, Chopra M, Basil MV, Brahmachari V, Bose M. Single nucleotide polymorphism in the genes of mce1 and mce4 operons of Mycobacterium tuberculosis: analysis of clinical isolates and standard reference strains. BMC Microbiol. 2011 Feb 23; 11:41 PMID: 21345183.

Saini NK, Sharma M, Chandolia A, Pasricha R, Brahmachari V, Bose M. Characterization of Mce4A protein of Mycobacterium tuberculosis: role in invasion and survival. BMC Microbiol. 2008 Nov 19; 8:200, PMID: 19019220.

Gupta G, Baghel AS, Bansal S, Tyagi TK, Kumari R, Saini NK, Ponnan P, Kumar A, Bose M, Saluja D, Patkar SA, Parmar VS, Raj HG. Establishment of glutamine synthetase of Mycobacterium smegmatis as a protein acetyltransferase utilizing polyphenolic acetates as the acetyl group donors. J Biochem. 2008 Dec;144(6):709-15, PMID: 18826970. 

Goldberg MF, Saini NK, Porcelli SA. Evasion of Innate and Adaptive Immunity by Mycobacterium tuberculosis. Microbiol Spectr. 2014 Oct;2(5). doi:  10.1128/microbiolspec.MGM2-0005-2013. Review. PubMed PMID: 26104343

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Albert Einstein College of Medicine
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Research Information