Faculty Profile

Dr. Sayan Nandi, Ph.D.

Sayan Nandi, Ph.D.

Research Assistant Professor, Department of Developmental & Molecular Biology

Areas of Research: Inflammation, glial biology, neurogenesis, synaptic plasticity, behavior, signal transduction, growth factor, noncoding RNA, developmental, vascular and stress-related disorders

Professional Interests

Two broad reserch goals are- 1) To understand how information is processed and encoded in the brain, and how these are altered in mental illnesses. 2) To understand how brain interacts with other organ systems in normal and pathological state.

Primary focus is on the roles of neural and immune cells in their maintenance of cellular communication and homeostasis within and outside the brain and its relevance in neurological and psychiatric conditions. 

Selected Publications

Selected research articles

Nandi, S., Alviña, K., Lituma, P.J., Castillo, P.E., Hébert, J.M. (2018). Neurotrophin and FGF signaling adapter proteins, FRS2 and FRS3 regulate dentate granule cell maturation and excitatory synaptogenesis. Neuroscience. 369:192-201 

Nandi, S., Gutin, G., Blackwood, C.A., Kamatkar, N.G., Lee, K.W., Wang, F., Fishell, G., Goldfarb, M., Hébert, J.M. (2017). FGF-dependent, context-driven role for FRS adapters in the early telencephalon. Journal of Neuroscience. 37(23):5690-5698   

Nandi, S., Chandramohan, D., Fioriti, L., Melnick, A.M., Hébert, J.M., Mason, C.E., Rajasethupathy, P., Kandel, E.R. (2016). Roles for small noncoding RNAs in silencing of retrotransposons in the mammalian brain. Proceedings of the National Academy of Sciences. 113(45):12697-12702

Nandi, S., Cioce, M., Yeung, Y.G., Nieves, E., Tesfa, L., Lin, H., Hsu, A.W., Halenbeck, R., Cheng, H.Y., Gokhan, S., Mehler, M.F., Stanley, E.R. (2013). Receptor-type protein tyrosine phosphatase zeta is a functional receptor for interleukin-34. The Journal of Biological Chemistry. 288(30):21972-86         

Nandi, S., Gokhan, S., Dai, X.M., Wei, S., Enikolopov, G., Lin, H., Mehler, M.F., Stanley, E.R. (2012). The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation. Developmental Biology. 367(2):100-13

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M.F., Conway, S.J., Ng, L.G., Stanley, E.R., Samokhvalov, I.M., Merad, M. (2010). Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science. 330(6005):841-5                      

Wei, S., Nandi, S., Chitu, V., Yeung, Y.G., Huang, M., Williams, L.T., Lin, H., Stanley, E.R. (2010). Functional overlap, but differential expression of CSF-1 and IL-34, in their CSF-1 receptor-mediated regulation of myeloid cells. Journal of Leukocyte Biology. 88(3):495-505 

Nandi, S., Akhter, M.P., Seifert, M.F., Dai, X.M., Stanley, E.R. (2006). Developmental and functional significance of the CSF-1 proteoglycan chondroitin sulfate chain. Blood. 107(2): 786-95  

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Research Information