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Faculty Profile

Andrew J. Yates, Ph.D.

Dr. Andrew J. Yates

Professional Interests

Our group combines mathematical and computational methods with experimental data to address questions in immunology, the ecology of host-pathogen interactions and the epidemiology of infectious disease. Our current interests include (i) modeling the dynamics of clearance of pathogen-infected cells by cytotoxic T lymphocytes (CTL), with the aim of establishing a quantitative framework to estimate the numbers of CTL required to provide sterilizing immunity in a given tissue. This work has applications to the early events in HIV infection; (ii) understanding how T cells integrate signals to determine the onset and extent of contraction following antigen-driven clonal responses; (iii) modeling mechanisms of thymocyte selection and naive T cell homeostasis; and (iv) modeling the decision-making underlying the generation of the transmission stage of the Malaria parasite in mammalian hosts.


Selected Publications

Asymmetric thymocyte death underlies the CD4:CD8 T cell ratio in the adaptive immune system
Charles Sinclair, Iren Bains, Andrew J. Yates*, Benedict Seddon* (joint senior auths)
Proc. Nat. Acad. Sci. USA, 110(31):E2905-E2914 (2013)
Models of self-peptide sampling identify candidate mechanisms of fate determination in thymocytes
Iren Bains, Hisse M. van Santen, Benedict Seddon, Andrew J. Yates
PLoS Computational Biology, 9(7):e1003102 (2013)
Clonally diverse T cell homeostasis is maintained by a common programme of cell cycle control
Thea Hogan, Andrey Shuvaev, Daniel Commenges, Andrew J. Yates, Robin Callard, Rodolphe Thiebaut and Benedict Seddon
Journal of Immunology, 190(8):3985-93 (2013)
Heterogeneity in thymic emigrants: implications for thymectomy and immunosenescence
Iren Bains, Andrew J. Yates, Robin Callard
PLoS One, 8(2):e49554 (2013)
Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T cell diversity with age
Philip L.F. Johnson, Andrew J. Yates, Jorg J. Goronzy, Rustom Antia
Proc. Nat. Acad. Sci. USA, 109(52):21432-7 (2012)
Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naive CD4+ and CD8+ T cells
Judith N. Mandl, Rachel Liou, Frederick Klauschen, Nienke Vrisekoop, João P. Monteiro, Andrew J. Yates, Alex Y. Huang, Ronald N. Germain
Proc. Nat. Acad. Sci. USA, 109(44):18036-41 (2012)
Plasticity in transmission strategies of the malaria parasite, Plasmodium chabaudi: environmental and genetic effects
Angus Cameron, Sarah E. Reece, Damien R. Drew, Daniel T. Haydon, Andrew J. Yates
Evolutionary Applications, 6(2):365-76 (2012)
The race for the prize - T cell trafficking strategies for optimal surveillance
Minyi Lee, Judith N Mandl, Ronald N Germain, Andrew J. Yates
Blood, 120(7):1432-8 (2012)
Virus replication strategies and the critical CTL numbers required for the control of infection
Andrew Yates, Minus van Baalen and Rustom Antia
PLoS Computational Biology, 7(11) e1002274 (2011)

More Information About Dr. Andrew Yates

Yates Group Homepage

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Albert Einstein College of Medicine
Michael F. Price Center
1301 Morris Park Avenue , Room 453B
Bronx, NY 10461

Tel: 718.678.1198
Fax: 718.678.1018

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