Faculty Profile

Dr. Mark E. Wagshul, Ph.D.

Mark E. Wagshul, Ph.D.

Associate Professor, Department of Radiology

Assistant Professor, Department of Physiology & Biophysics

Professional Interests

My primary interest is in using imaging technology for elucidating the pathophysiology of hydrocephalus.  Hydrocephalus, a disease which is most common in newborns and young children, although it is also one of the causes of dementia in the elderly, is characterized by an increased accumulation of fluid in the brain.  It is associated with brain development, cognitive and motor function delays and deficits.  In collaboration with researchers at the Washington University in St. Louis, we are working on characterizing the role of brain pulsations in the development and progression of ventricular dilation in hydrocephalus.  We use MRI and multi-photon confocal microscopy to image blood and cerebrospinal fluid flow in an animal, and are now working with the Einstein Behavioral Core to evaluate potential biomarkers of disease severity and of recovery following shunting of the fluid from the brain.  The work obviously has important clinical application, and we are working on improved imaging techniques for quantifying pulsatile fluid flow in the brain and its relationship to hydrocephalus and recovery following shunt surgery.

Finally, I am interested in MRI pulse sequence development, i.e. manipulating the MRI machine to extract new types of information from MRI images.

Focus areas:

  • Quantitative flow imaging
  • Hydrocephalus
  • Animal models of disease
  • Dynamic MRI and sleep apnea
  • Multiple sclerosis
  • Diffusion tensor imaging
  • Volumetric analysis
  • MRI Pulse sequence development

Selected Publications

  1. Lucas M., Wagshul M.E., Izzetoglu M., Holtzer R. “Moderating Effect of White Matter Integrity on Brain Activation During Dual-Task Walking in Older Adults.”, J Gerontol A Biol Sci Med Sci. Jun 18 (2018).
  2. K. Tan, A. Meiri, W. Mowrey, R. Abbott, J.T. Goodrich, A.L. Sandler, A.K. Suri, M.L. Lipton, M.E. Wagshul, “Diffusion tensor imaging and ventricular volume quantification in chronically shunted hydrocephalus patients: a matched case-control study”, Journal of Neurosurgery (2018).
  3. J. Cha, J.A. Zea-Hernandez, S. Sin, K. Graw-Panzer, K. Shifteh, C.R. Isasi, M.E. Wagshul, E.E. Moran, J. Posner, M.E. Zimmerman, R. Arens.  "The Effects of Obstructive Sleep Apnea Syndrome on the Dentate Gyrus and Learning and Memory in Children." J Neurosci. 37(16):4280-4288 (2017).
  4. D.M. Wootton, S. Sin, H. Luo, A. Yazdani, J.M. McDonough, M.E. Wagshul, C.R. Isasi, R. Arens, "Computational Fluid Dynamics Upper Airway Effective Compliance, Critical Closing Pressure, and Obstructive Sleep Apnea Severity in Obese Adolescent Girls", J Appl Physiol, 121(4):925-931 (2016).
  5. Y. Tong, J.K.Udupa, D. Odhner, C. Wu, S. Sin, M.E. Wagshul, R. Arens, "Minimally Interactive Segmentation of 4D Dynamic Upper Airway MR Images via Fuzzy Connectedness", Medical Physics 43:2323 (2016).
  6. Y. Tong, J.K. Udupa, D. Odhner, S. Sin, M.E. Wagshul, R. Arens, "A novel non-registration based segmentation approach of 4D dynamic upper airway MR images: minimally interactive fuzzy connectedness",  Proc. SPIE 9038, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging, 90380Z (March 13, 2014); doi:10.1117/12.2044473.
  7. M.E. Wagshul, S. Sin, K. Shifteh, M.L. Lipton, R. Arens, "Novel Retrospective, Respiratory-Gating Method Enables 3D, High Resolution, Dynamic Imaging of the Upper Airway during Tidal Breathing", Mag Reson Med (2013).
  8. H.J Yu, C. Christodoulou, V. Bhise, D. Greenblatt, Y. Patel, D. Serafin, M. Maletic-Savatic, L.B. Krupp, M.E. Wagshul, "Multiple white matter tract abnormalities underlie cognitive impairment in RRMS", Neuroimage, 59:3713-3722 (2012). PMID: 22062194.
  9. S. Rashid, J.P. McAllister, Y. Yu, M.E. Wagshul, “Neocortical capillary flow pulsatility is not elevated in experimental communicating hydrocephalus”, J Cereb Blood Flow Metab, 32:318-329  (2012).
  10. M.E. Wagshul, P.K. Eide, J.R. Madsen, “The Pulsating Brain: A review of experimental and clinical studies of intracranial pulsatility”, Fluid and Barriers of the CNS, 8:5 (2011).
  11. M.E. Wagshul, J.P. McAllister, S. Rashid, J. Li, M.R. Egnor, M.L. Walker, M. Yu, S.D. Smith, G. Zhang, J.J. Chen, H. Benveniste, “Ventricular dilation and elevated aqueductal pulsations in a new experimental model of communicating hydrocephalus”, Exp Neurol, 218(1):33-40 (2009).
  12. M.E. Wagshul, E.J. Kelly, H.J. Yu, B. Garlick, T. Zimmerman, M.R. Egnor, “Resonant and notch behavior in intracranial pressure dynamics”, J Neurosurg Pediatr. 3(5):354-64 (2009).
  13. M. Maletiæ-Savatiæ, L.K. Vingara, L.N. Manganas, Y. Li, S. Zhang, A. Sierra, R. Hazel, D. Smith, M.E. Wagshul, F. Henn, L. Krupp, G. Enikolopov, H. Benveniste, P.M. Djuriæ, I. Pelczer, “Metabolomics of neural progenitor cells: a novel approach to biomarker discovery”, Cold Spring Harb Symp Quant Biol. 73:389-401 (2008).
  14. F.A. Dilmanian, P. Romanelli, Z. Zhong, R. Wang, M.E. Wagshul, J. Kalef-Ezra, M.J. Maryanski, E.M. Rosen, D.J. Anschel, “Microbeam radiation therapy: Tissue dose penetration and BANG-gel dosimetry of thick-beam array interlacing, Eur J Radiol, 68:S129-S136 (2008).
  15. R. Zou, E.H. Park, E. McCormack-Kelly, M. Egnor, M.E. Wagshul, J.R. Madsen, “Intracranial pressure waves: Characterization of a pulsation absorber with notch filter properties using systems analysis”, J Neurosurg Pediatrics, 2:83-94 (2008).
  16. G. Nagra, J. Li, J.P. Mcallister, J. Miller, M.E. Wagshul, M. Johnston, “Lymphatic cerebrospinal fluid absorption impaired in a kaolin-induced hydrocephalus model in the rat”, Am J Physiol Regul Integr Comp Physiol, 294(5):R1752-1759 (2008).
  17. J. Li, Y. Shen, J.P. McAllister II, M.E. Wagshul, J.M. Miller, M.R. Egnor, M.G. Johnston, E.M. Haacke, M.L. Walker, “Communicating Hydrocephalus in Adult Rats with Obstruction of the Basal Cisterns or Cortical Subarachnoid Spaces, Experimental Neurology, 211:351-361 (2008). 
  18. L.R. Mujica-Parodi, M. Korgaonkar, B. Ravindranath, T. Greenberg, D. Tomasi, M. E. Wagshul, B. Ardekani, D. Guilfoyle, J. Kilpatrick, M. Sedler, D. Malaspina, “Limbic Dysregulation Predicts Lowered Heart Rate Variability and Increased Trait Anxiety in Healthy Adults”, Human Brain Mapping, 30:47-58  (2008).
  19. L. Manganas, S. Zhang, R. Hazel, M. E. Wagshul, H. Benveniste, P. Djuric, G. Enikolopov, M. Maletic-Savatic, “Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain”, Science 318(5852):980-985 (2007).
  20. E.J. McCormack, M.R. Egnor, M.E. Wagshul, “Improved cerebrospinal fluid flow measurements using phase contrast balanced steady state free precession”, Magnetic Resonance Imaging, 25:172-182 (2007).
  21. M.E. Wagshul, J.J. Chen, M.R. Egnor, E.J. McCormack, P.E. Roche, “Amplitude and Phase of Cerebrospinal Fluid Pulsations: Experimental Studies and Review of the Literature”, J Neurosurg 104:810-819 (2006).
  22. R. Zou, E. McCormack, M. Egnor, D. Kim, M. Wagshul, B. Macdonald, J. Madsen, “Increased Phase Synchronization between Intracranial Pressure and Arterial Blood Pressure during Elevated Intracranial Pressure in Dogs.”, Conf Proc IEEE Eng Med Biol Soc. 1(1):315-318 (2005).
  23. M. Egnor, M. Wagshul, L. Zheng, A. Rosiello, “Resonance and the Synchrony of Arterial and CSF Pulsations”, Pediat Neurosurg38:273-276 (2003).
  24. J.P. Mugler, B. Driehuys, J.R. Brookeman, G.D. Cates, S.S. Berr, R.G. Bryant, T.M. Daniel, E.E. de Lange, J.H. Downs, C.J. Erickson, W. Happer, D.P. Hinton, N.F. Kassel, T. Maier, C.D. Phillips, B.T. Saam, K.L. Sauer, and M. E. Wagshul, “MR Imaging and Spectroscopy Using Hyperpolarized 129Xe Gas: Preliminary Human Results”, Magn. Res. Med. 37, 809-815 (1997).
  25. M. E. Wagshul, T. Button, H. Li, Z. Liang, C. Springer, K. Zhong and A. Wishnia, “In Vivo MR Imaging and Spectroscopy Using Hyperpolarized 129Xe”, Magn. Res. Med.36, 183 (1996).
  26. L.P. Ratliff, M.E. Wagshul, P.D. Lett, S.L. Rolston and W.D. Phillips, “Photoassociative Spectroscopy of 1g, Ou+, and Og- States of Na2”, J. Chem. Phys. Lett. 101, 2638 (1994). 
  27. M.E. Wagshul and T.E. Chupp, “Laser Optical Pumping of High-density Rb in Polarized 3He Targets”, Phys. Rev. A 49, 3854 (1994).
  28. T. E. Chupp, M. E. Wagshul, K. P. Coulter, A. B. McDonald and W. Happer, “Polarized, High-density, Gaseous 3He Targets”, Phys. Rev. C 36, 2244-2251 (1987). 

More Information About Dr. Mark Wagshul

Gruss Magnetic Resonance Research Center

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Albert Einstein College of Medicine
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MRRC, Room 208
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