My primary interest is in using imaging technology for elucidating the pathophysiology of hydrocephalus. Hydrocephalus, a disease which is most common in newborns and young children, although it is also one of the causes of dementia in the elderly, is characterized by an increased accumulation of fluid in the brain. It is associated with brain development, cognitive and motor function delays and deficits. In collaboration with researchers at the University of Utah, we are working on characterizing the role of brain pulsations in the development and progression of ventricular dilation in hydrocephalus. We use MRI and multi-photon confocal microscopy to image blood and cerebrospinal fluid flow in an animal, and are now working with the Einstein Behavioral Core to evaluate potential biomarkers of disease severity and of recovery following shunting of the fluid from the brain. The work obviously has important clinical application, and we are working on improved imaging techniques for quantifying pulsatile fluid flow in the brain and its relationship to hydrocephalus and recovery following shunt surgery.
I am also interested in a technique called MR-spectroscopy (MRS), in which MRI can be used to quantify concentrations of common metabolites in the brain. We use MRS to understand white and grey matter degradation in multiple sclerosis. Using techniques based on principle component analysis and metabolomic analysis, we are able detect changes in MS lesions as well as in "normal-appearing" white matter in the MS brain. We also use diffusion tensor imaging, a technique which can detect changes in myelin microstructure, as well as volumetric analyses to understand the effect of hippocampal atrophy, for example, on cognitive function. This work is ongoing in collaboration with investigators are Stony Brook University.
Finally, I am interested in MRI pulse sequence development, i.e. manipulating the MRI machine to extract new types of information from MRI images.Focus areas:
- Quantitative flow imaging
- Animal models of disease
- Multi-photon confocal microscopy
- Multiple sclerosis
- MR spectroscopy
- Diffusion tensor imaging
- Volumetric analysis
- MRI Pulse sequence development
1. M.E. Wagshul
, J.P. McAllister, S. Rashid, J. Li, M.R. Egnor, M.L. Walker, M. Yu, S.D. Smith, G. Zhang, J.J. Chen, H. Benveniste, “Ventricular dilation and elevated aqueductal pulsations in a new experimental model of communicating hydrocephalus”, Exp Neurol
, 218(1):33-40 (2009).
2. M.E. Wagshul
, E.J. Kelly, H.J. Yu, B. Garlick, T. Zimmerman, M.R. Egnor, “Resonant and notch behavior in intracranial pressure dynamics”, J Neurosurg Pediatr
. 3(5):354-64 (2009).
3. M. Maletiæ-Savatiæ, L.K. Vingara, L.N. Manganas, Y. Li, S. Zhang, A. Sierra, R. Hazel, D. Smith, M.E. Wagshul
, F. Henn, L. Krupp, G. Enikolopov, H. Benveniste, P.M. Djuriæ, I. Pelczer, “Metabolomics of neural progenitor cells: a novel approach to biomarker discovery”, Cold Spring Harb Symp Quant Biol.
4. F.A. Dilmanian, P. Romanelli, Z. Zhong, R. Wang, M.E. Wagshul
, J. Kalef-Ezra, M.J. Maryanski, E.M. Rosen, D.J. Anschel, “Microbeam radiation therapy: Tissue dose penetration and BANG-gel dosimetry of thick-beam array interlacing, Eur J Radiol,
5. R. Zou, E.H. Park, E. McCormack-Kelly, M. Egnor, M.E. Wagshul
, J.R. Madsen, “Intracranial pressure waves: Characterization of a pulsation absorber with notch filter properties using systems analysis”, J Neurosurg Pediatrics,
6. G. Nagra, J. Li, J.P. Mcallister, J. Miller, M.E. Wagshul
, M. Johnston, “Lymphatic cerebrospinal fluid absorption impaired in a kaolin-induced hydrocephalus model in the rat”, Am J Physiol Regul Integr Comp Physiol,
7. J. Li, Y. Shen, J.P. McAllister II, M.E. Wagshul
, J.M. Miller, M.R. Egnor, M.G. Johnston, E.M. Haacke, M.L. Walker, “Communicating Hydrocephalus in Adult Rats with Obstruction of the Basal Cisterns or Cortical Subarachnoid Spaces, Experimental Neurology,
8. L.R. Mujica-Parodi, M. Korgaonkar, B. Ravindranath, T. Greenberg, D. Tomasi, M. E. Wagshul
, B. Ardekani, D. Guilfoyle, J. Kilpatrick, M. Sedler, D. Malaspina, “Limbic Dysregulation Predicts Lowered Heart Rate Variability and Increased Trait Anxiety in Healthy Adults”, Human Brain Mapping, 30:
9. L. Manganas, S. Zhang, R. Hazel, M. E. Wagshul
, H. Benveniste, P. Djuric, G. Enikolopov, M. Maletic-Savatic, “Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain”, Science
10. E.J. McCormack, M.R. Egnor, M.E. Wagshul,
“Improved cerebrospinal fluid flow measurements using phase contrast balanced steady state free precession”, Magnetic Resonance Imaging, 25
11. M.E. Wagshul
, J.J. Chen, M.R. Egnor, E.J. McCormack, P.E. Roche, “Amplitude and Phase of Cerebrospinal Fluid Pulsations: Experimental Studies and Review of the Literature”, J Neurosurg 104
12. R. Zou, E. McCormack, M. Egnor, D. Kim, M. Wagshul
, B. Macdonald, J. Madsen, “Increased Phase Synchronization between Intracranial Pressure and Arterial Blood Pressure during Elevated Intracranial Pressure in Dogs.”, Conf Proc IEEE Eng Med Biol Soc. 1
13. M. Egnor, M. Wagshul
, L. Zheng, A. Rosiello, “Resonance and the Synchrony of Arterial and CSF Pulsations”, Pediat Neurosurg
14. J.P. Mugler, B. Driehuys, J.R. Brookeman, G.D. Cates, S.S. Berr, R.G. Bryant, T.M. Daniel, E.E. de Lange, J.H. Downs, C.J. Erickson, W. Happer, D.P. Hinton, N.F. Kassel, T. Maier, C.D. Phillips, B.T. Saam, K.L. Sauer, and M. E. Wagshul
, “MR Imaging and Spectroscopy Using Hyperpolarized 129
Xe Gas: Preliminary Human Results”, Magn. Res. Med. 37
, 809-815 (1997).
15. M. E. Wagshul
, T. Button, H. Li, Z. Liang, C. Springer, K. Zhong and A. Wishnia, “In Vivo
MR Imaging and Spectroscopy Using Hyperpolarized 129
Xe”, Magn. Res. Med.
, 183 (1996)
16. L.P. Ratliff, M.E. Wagshul
, P.D. Lett, S.L. Rolston and W.D. Phillips, “Photoassociative Spectroscopy of 1g
, and Og-
States of Na2
”, J. Chem. Phys. Lett. 101
, 2638 (1994).
17. M.E. Wagshul
, K. Helmerson, P.D. Lett, W.D. Phillips, L.P. Ratliff and S.L. Rolston, “Observation of Long Range Molecular States of Na2
by Photoassociation of Laser Cooled Na”, in Laser Spectroscopy XI,
Ed. by L. Bloomfield, T. Gallagher, and S. Larson (AIP, New York, 1994), p. 29.
18. M.E. Wagshul
and T.E. Chupp, “Laser Optical Pumping of High-density Rb in Polarized 3He
Targets”, Phys. Rev. A 49
, 3854 (1994).
19. M.E. Wagshul
, K. Helmerson, P.D. Lett, S.L. Rolston and W.D. Phillips, “Hyperfine Effects on Associative Ionization of Ultracold Sodium”, Phys. Rev. Lett. 70
, 2074 (1993).
20. Wagshul, M. E.,
K. Helmerson, P. D. Lett, W. D. Phillips, L. P. Ratliff, S. L. Rolston, “Observation of Long Range Molecular States of Na2
by Photo-associative Spectroscopy of Laser Cooled Na”, AIP Conference Proceedings, Vol. 290, No. 1, 20 October 1993, pp. 29-34.
21. P.D. Lett, K. Helmerson, W.D. Phillips, L.P. Ratliff, S.L. Rolston and M.E. Wagshul
, “Spectroscopy of Na2
by Photoassociation of Laser Cooled Sodium”, Phys. Rev. Lett., 71
, 2200 (1993).
22. M.E. Wagshul
and T.E. Chupp, “Optical Pumping of High-density Rb with a Broadband Dye Laser and GaAlAs Diode Laser Arrays: Application to 3
He Polarization”, Phys. Rev. A 40
, 4447-4454 (1989).
23. T. E. Chupp, M. E. Wagshul
, K. P. Coulter, A. B. McDonald and W. Happer, “Polarized, High-density, Gaseous 3
He Targets”, Phys. Rev. C 36
, 2244-2251 (1987).