Faculty Profile

Dr. Jeannette R. Mahoney, Ph.D.

Jeannette R. Mahoney, Ph.D.

Assistant Professor, The Saul R. Korey Department of Neurology

Areas of Research: Multisensory Integration (MSI); Aging; Gait; Balance & Postural Stability; Cognition; Executive Functioning; Mild Parkinsonian Symptoms (MPS)

Professional Interests

Multisensory integration (MSI) is an integral aspect of functioning and mobility in everyday life and ability to function well in the real world requires intact MSI. MSI is not well understood in aging, and its relation to cognitive and motor function has not been fully evaluated. The main objective of my research is to investigate the behavioral, functional, and anatomical correlates of MSI in older adults and to determine whether MSI has associations with specific cognitive and motor outcomes. Studying the facilitative benefit of multisensory information processing in older adults could have important clinical and public health implications! These include potentially providing insight into the cognitive and physical attributes of the aging process, affording an understanding of the biological basis of aging, and subsequently aiding in the identification of opportunities to introduce cognitive and physical remediation to older adults. Although admittedly speculative at this point, we believe that optimizing integration of visual-somatosensory inputs may ultimately provide the framework for successful interventions that will reduce falls, improve mobility, and help maintain functional independence in older adults.

Selected Publications

  1. Santos, D., Mahoney, J.R., Allali, G., & Verghese, J. Physical Activity in Older Adults with Mild Parkinsonian Signs: A cohort study. Journal of Gerontology, Medical Sciences, Accepted 2017.
  2. Mahoney, J.R., Oh-Park, M., Ayers, E., & Verghese, J.  Quantitative Trunk Sway and Prediction of Incident Falls in Older Adults. Gait and Posture, 58: 183-187, 2017. PMID: 28797962
  3. Chen, M., Pillemer, S., England, S., Izzetoglu, M., Mahoney, J.R., & Holtzer, R. Neural Correlates of Obstacle Negotiation in Older Adults: An fNIRS Study.  Gait and Posture, 18 (58): 130-135, 2017. PMID: 28778021
  4. Holtzer, R., Schoen, C., Demetriou, E., Mahoney, J.R., Izzetoglu, M., Wang, C., & Verghese, J. Stress and gender effects on prefrontal cortex oxygenation levels assessed during single and dual-task walking conditions. Eur J Neurosci., 45 (5) :660-670, 2017. PMID: 28028863
  5. Verghese, J., Ayers, E., Mahoney, J.R., Ambrose, A., Wang, C., Holtzer, R. Cognitive remediation to enhance mobility in older adults: the CREM study. Neurodegener Dis Manag, 6(6):457-466, 2916. PMID:2781345
  6. Holtzer, R., Yuan, J, Verghese, J., Mahoney, J.R., Izzetoglu, M., & Wang, C. Interactions of Subjective and Objective Measures of Fatigue Defined in the Context of Brain Control of Locomotion.Journal of Gerontology, Medical Sciences, 72(3):417-423, 2017. PMID: 27567110
  7. Dumas, K., Holtzer, R., & Mahoney, J.R. Visual-Somatosensory Integration in Older Adults: Links to Sensory Acuity and Balance. Multisensory Research, 29 (4-5): 397-420, 2016.
  8. Holtzer, R., Verghese, J., Allali, G., Izzetoglu, M., Wang, C., & Mahoney, J.R., Neurological Gait Abnormalities Moderate the Functional Brain Signature of the Posture First Hypothesis.Brain Topography, 2015. PMID: 26613725 
  9. Mahoney, J.R., Holtzer, R., Izzetoglu, M., Zemon, V., Verghese, J., & Allali, G. The role of the prefrontal cortex in postural control in Parkinsonian syndromes. Brain Research, 163: 126-138, 2015. PMID: 26551767 
  10. LeMonda, B., Mahoney, J.R., Verghese, J., & Holtzer, R. The Association between High Neuroticism-Low Extraversion and Dual-Task Performance during Walking while Talking in Healthy Older Adults. J Int Neuropsychol Soc., 21 (7):519-530, 2015. PMID: 26527241
  11. Mahoney, J.R., Molholm, S., Butler, J.S., Sehatpour, P., Gomez-Ramirez, M., Ritter, W. & Foxe, J.J.  Keeping in Touch with the Visual System: Spatial Alignment and Multisensory Integration of Visual- Somatosensory Inputs. Frontiers in Psychology, 5 (6): 1068, 2015. PMID: 26300797
  12. Mahoney, J.R., Verghese, J., Dumas, K. & Holtzer, R. Visual-Somatosensory Integration is linked to Physical Activity Level in Older Adults. Multisensory Research, 28 (1-2): 11-29, 2015.  PMID: 26152050
  13. Holtzer, R., Mahoney, J.R., Izzetoglu, M., Wang, C., England, S., & Verghese, J. Online Fronto-cortical Control of Simple and Attention-Demanding Locomotion in Humans. Neuroimage, 112: 152-159, 2015. PMID: 25765257
  14. England, S., Verghese, J., Mahoney, J.R., Trantzas, K., & Holtzer, R. Three level rating of turns while walking, Gait and Posture, 41(1):300-3, 2015.  PMID: 25282258
  15. Lee, S., Verghese, J., Holtzer, R., Mahoney, J.R., & Oh-Park, M. Trunk Sway during Walking among Older Adults: Norms and Correlation with Gait Velocity. Gait & Posture, 40(4):676-681, 2014. PMID: 25155693
  16. Mahoney, J.R., Holtzer, R., Dumas, K., & Verghese, J. Visual-Somatosensory Integration & Balance: Evidence for Psychophysical Integrative Differences in Aging. Multisensory Research, 27(1): 17-42, 2014. PMID: 25102664
  17. Mahoney, J.R., Verghese, J., Holtzer, R. & Allali, G. The evolution of mild parkinsonian signs in aging. Journal of Neurology, 261(10):1922-1928, 2014. PMID: 25047763
  18. Allali, G., Verghese, J. & Mahoney, J.R.  Contributions of Parkinsonian features to Gait in the Elderly. Age (Dordr), 36:9678, 2014. PMID: 24981115
  19. Holtzer, R., Epstein, N., Mahoney, J.R., Izzetoglu, M., & Blumen, H.M. Neuroimaging of Mobility in Aging: A Targeted Review. Journal of Gerontology, Medical Sciences, 69(11):1375-88, 2014. PMID: 24739495
  20. Mahoney, J.R., Verghese, J., Dumas, K., & Holtzer, R. Visual-Somatosensory Integration in Aging: Does Stimulus Location Really Matter? Visual Neuroscience, 31(3):275-83, 2014. PMID: 24698637
  21. Parihar, R., Mahoney, J.R., & Verghese, J.  Relationship of Gait and Cognition in the Elderly.  Current Translational Geriatrics and Experimental Gerontology Reports, 2:167-173, 2013. PMID: 24349877
  22. Shapiro, M., Mahoney, J., Zingman, B, Pogge, D, & Verghese, J.  Apathy Correlates with Cognitive Performance, Functional Disability, and HIV RNA Plasma Levels in HIV-Positive Individuals. Journal of Clinical and Experimental Neuropsychology, 35(9):934-945, 2013. PMID: 24090038
  23. Shapiro, M, Mahoney, J.R., Peyser, D., Zingman, B. & Verghese, J.  Cognitive Reserve Protects Against Apathy in Individuals with Human Immunodeficiency Virus. Archives of Clinical Neuropsychology, 29(1):110-120, 2014. PMID: 24021844
  24. Mahoney, J.R., Verghese J, Dumas K, Wang C, Holtzer R. The effect of multisensory cues on attention in aging. Brain Res. 1472, 63-73, 2012. PMID: 22820295
  25. Holtzer, R., Mahoney, J.R., Verghese, J. Intraindividual variability but not speed of processing or conflict resolution predicts performance differences in gait speed in older adults. Journal of Gerontology: Medical Sciences, 69(8): 980-986, 2014. PMID: 24285744
  26. Oh-Park, M., Holtzer, R., Mahoney, J., Wang, Raghavan, P. & Verghese, J. Motor dual-task effect on gait and task of upper limbs in older adults under specific task prioritization: pilot study.  Aging Clinical and Experimental Research, 25(1):99-106, 2013. PMID: 23740639
  27. Oh-Park, M., Holtzer, R., Mahoney, J., Wang, C., & Verghese, J.  Effect of treadmill training on specific gait parameters in older adults with frailty: case series. J Geriatr Phys Ther. 34(4), 184-188, 2011. PMID: PMC3226950
  28. Mahoney, J.R., Li, P., Oh-Park, M., Verghese, J., & Holtzer, R. Multisensory Integration Across the Senses in Young and Old Adults. Brain Research, 426, 43-53, 2011. PMID: PMC3232048
  29. Holtzer, R., Shuman, M., Mahoney, J., Lipton, R., & Verghese, J. Cognitive Fatigue Defined in the Context of Attention Networks. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn., 18, 108-128, 2011. PMID: PMC3058923
  30. Holtzer,R., Mahoney, J.R., Izzetoglu,M., Izzetoglu,K., Onaral, B., & Verghese, J.  fNIRS Study of Walking and Walking While Talking in Young and Old Individuals. J Int Neuropsychol Soc., 16(5), 877-89, 2011. PMID: PMC3148759
  31. Mahoney, J., Verghese, J. Goldin, Y., Lipton, R. & Holtzer, R.  Alerting, Orienting, and Executive Attention in Older Adults. J Int Neuropsychol Soc., 16(5), 877-889, 2010. PMID: PMC3134373
  32. Verghese J., Mahoney J., Wang C., Ambrose A.F., & Holtzer, R. Effect of cognitive remediation on gait in sedentary seniors. J Gerontol A Biol Sci Med Sci.,65(12), 1338-1343, 2010. PMID: 20643703
  33. Katz, R., De Sanctis, P., Mahoney, J.R., Sehatpour, P., Murphy, C., Gomez-Ramirez, M., Alexopoulos, G.A., & Foxe, J.J.  Cognitive Control in Late-Life Depression: Response inhibition deficits and dysfunction of the Anterior Cingulate Cortex. Am J Geriatr Psychiatry, 18(11), 1017-1025, 2010. PMID: 20808083
  34. Sehatpour, P., Molholm, S., Schwartz, T.H., Mahoney, J.R., Mehta, A., Javitt, D., Stanton, P.K., & Foxe, J.J. A human intracranial study of long-range oscillatory coherence across a frontal-occipital-hippocampal brain network during visual object processing. Proc Natl Acad Sci U S A., 105(11), 4399-4404, 2008. PMID: PMC 2393806
  35. Gomez-Ramirez, M., Higgins, B.A., Rycroft, J.A., Owen, G.N., Mahoney, J., Shpaner, M., &  Foxe, J.J. The deployment of intersensory selective attention: A high-density electrical mapping study of the effects of Theanine. Clin Neuropharmacol., 30 (1), 25-38, 2007. PMID: 17272967
  36. Butler, P.D., Martinez, A., Foxe, J.J., Kim, D., Zemon, V., Silipo, G., Mahoney, J., Shpaner, M., Jalbrzikowski, M., &. Javitt, D. C.  Subcortical visual dysfunction in schizophrenia drives secondary cortical impairments. Brain, 130, 417-430, 2007. PMC2072909

More Information About Dr. Jeannette Mahoney

Neurology Division of Cognitive & Motor Aging

Saul R. Korey Department of Neurology

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Albert Einstein College of Medicine
1225 Morris Park Avenue
Van Etten, Room 316G
Bronx, NY 10461

Tel: 718.430.3809
Fax: 718.430.3829

Research Information