Faculty Profile

Dr. Regina Hanstein, Ph.D.

Regina Hanstein, Ph.D.

Instructor, Department of Orthopaedic Surgery

Areas of Research: pediatric neuromuscular disorders, spine, sports medicine, trauma, cerebral palsy

Professional Interests

I am the Assistant Director of Research for the Division of Pediatric Orthopaedics and an experienced research scientist, data analyst and creative problem solver with a passion for science communication. I am dedicated to enhancing and facilitating research efforts of medical professionals and students to optimize research performance with high-quality outcomes. Areas of interest include pediatric neuromuscular disorders, pediatric orthopaedic trauma and cerebral palsy.

After earning my PhD from the University of Mainz, Germany, I completed my postdoctoral training in the neuroscience department of the Albert Einstein College of Medicine. I studied pain signaling pathways and mechanisms for pain release. In 2015, I joined the department of orthopaedic surgery as a research coordinator. In this role, I design, implement and conduct clinical trials and research projects. As both a scientist and administrator, I thrive in environments that provide opportunities to work in and lead teams, use my analytical skills to solve problems and manage complex projects.

I published numerous articles arising from my research in pediatric orthopaedics, neuroscience and translational science. In addition, I mentor student research and serve as faculty advisor for clinical fellows.



Selected Publications

Gomez JA, Grzywna A, Hanstein R, Emans JB, Hresko MT, Hedequist D, Karlin LI, Glotzbecker MP. Staged Growing Rods With Preimplantation of Spinal Anchors for Complex Early Onset Scoliosis. J Pediatr Orthop. 2017 Feb 27. doi: 10.1097/BPO.0000000000000957. [Epub ahead of print]

Burton D, Hanstein R, Schulz JF, Gomez JA. How Are We Affecting Spinopelvic Parameters in Patients with Idiopathic Scoliosis. J Pediatr Orthop. 2017 Mar;37(2):156-157. doi: 10.1097/01.bpo.0000513119.90348.97.

Gomez JA, Lafage V, Scuibba DM, Bess S, Mundis GM Jr, Liabaud B, Hanstein R, Shaffrey C, Kelly M, Ames C, Smith JS, Passias PG, Errico T, Schwab F; International Spine Study Group. Adult Scoliosis Deformity Surgery: Comparison of Outcomes Between 1 vs. 2 Attending Surgeons. Spine (Phila Pa 1976). 2017 Jan 16. doi: 10.1097/BRS.0000000000002071.

Hanstein R, Hanani M, Scemes E, Spray DC. (2016): Glial pannexin1 contributes to tactile hypersensitivity in a mouse model of orofacial pain. Sci Rep. 2016 Dec 2;6:38266. doi: 10.1038/srep38266.

Leong DJ, Choudhury M, Hanstein R, Hirsh DM, Kim SJ, Majeska RJ, Schaffler MB, Hardin JA, Spray DC, Goldring MB, Cobelli NJ, Sun HB (2014). Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model. Arthritis Res Ther. 2014 Dec 17;16(6):508. doi: 10.1186/s13075-014-0508-y.

Hanstein, R., Negoro, H., Patel, N.K., Charollais, A., Meda, P., Spray, D.C., Suadicani, S.O., Scemes, E. (2013): Promises and pitfalls of conditional Pannexin1 knockout mice. Front Pharmacol. May 9;4:61. doi: 10.3389/fphar.2013.00061. PMID: 23675350 PMCID: PMC3648696

Stumm, C., Hiebel, C., Hanstein, R., Purrio, M., Nagel, H., Conrad, A., Lutz, B., Behl, C., Clement, A.B. (2013): Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition. Neurobiol Aging. Nov;34(11):2574-84. doi: 10.1016/j.neurobiolaging.2013.05.027. Epub 2013 Jul 6. PMID: 23838176

Spray, D.C., Hanstein, R., Lopez-Quintero, S.V., Stout, R., Suadicani, S.O., Thi, M.M. (2012): Gap junctions and Bystander Effects: Good Samaritans and executioners. Wires Membrane Transport and Signaling, Jan;2(1):1-15. Epub 2012 Dec 11. PMID: 23565352 PMCID: PMC3614363

Hanstein, R., Zhao, J.B., Basak, R., Smith, D.N., Zuckerman, Y.Y., Hanani, M., Spray, D.C., Gulinello, M. (2010): Focal Inflammation Causes Carbenoxolone-Sensitive Tactile Hypersensitivity in Mice. Open Pain J. Jan;3:123-133. PMID: 21151805 PMCID: PMC2999631

Hanstein, R., Trotter, J., Behl, C., Clement, A.B. (2009): CRH Protects Neurons towards Oxidative Stress by Increasing Connexin43 Expression and Promoting Gap Junctional Coupling. Molecular Endocrinology, Sep;23(9):1479-93. PMID: 19460861 PMCID: PMC2737551

Hanstein, R., Lu, A., Wurst, W., Holsboer, F., Deussing, J., Clement, A.B., Behl, C. (2008): Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress. Neuroscience, Oct 15;156(3):712-21. PMID: 18708129

Clement, A.B., Hanstein, R., Schröder, A., Nagel, H., Endres, K., Fahrenholz, F., Behl, C. (2008): Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress. Neuroscience; Mar 18;152(2):459-68. PMID: 18276079

Book Chapter

Wahezi, S.E., Hanstein, R., Spray, D.C. (2013): Understanding the pathways of pain. Chapter 12. In: Basic Science of Spinal Diseases. Eds Dr. Alok Sharan, Dr. Alexander Vaccaro and Dr. Simon Tang. Jaypee Brothers Medical Publishers Pvt. Ltd., 1 edition

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