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Faculty Profile

Bin Zhou, M.D., Ph.D.

Dr. Bin Zhou

Associate Professor, Department of Genetics

Associate Professor, Department of Pediatrics

Associate Professor, Department of Medicine (Cardiology)

 

Professional Interests

The research of my lab focuses on molecular and cellular mechanisms in cardiovascular development and diseases. We apply an integrated approach of mouse genetics, developmental embryology, cell and molecular biology to study how cardiovascular precursor cells are specified and differentiated into different cardiovascular tissues during development and regeneration. We are currently working on four projects: (1) endocardial cell specification and differentiation, (2) transcriptional regulation of cardiac valve development, (3) modeling of heart valve diseases, and (4) epigenetic and genetic regulation of heart and coronary vessel development.

 

Selected Publications

  1. Zhou, B., Boudreau, N., Coulber, C., Hammarback, J. and Rabinovitch, M. Microtubule-associated Protein 1 Light Chain 3 is a Fibronectin mRNA-binding Protein Linked to mRNA Translation in Lamb Vascular Smooth Muscle Cells.  J. Clin. Invest. 100:3070-3082, 1997 (On the issue cover)
  2. Zhou, B., Hammarback, J. and Rabinovitch, M. Microtubule involvement in translational regulation of fibronectin mRNA by light chain 3 of microtubule-associated protein 1 in vascular smooth muscle Cells.   Circ. Res.  83:481-489, 1998 (On the issue cover)
  3. Zhou, B., Coulber, C. and Rabinovitch, M. Tissue-specific and developmental regulation of Transforming growth factor -fl expression in fetal lamb ductus arteriosus. Pediatr. Res. 44:865-72, 1998
  4. Jones, P. L., Jones, F. S., Zhou, B. and Rabinovitch, M. Induction of vascular smooth muscle cell tenascin-C gene expression by denatured type I collagen is dependent upon a beta3 integrin-mediated mitogen-activated protein kinase pathway and a 122-base pair promoter element. J. Cell Sci. 112:435-445, 1999
  5. Mason, C. A., Bigras, J. L., O'Blenes, S. B., Zhou, B., McIntyre, B., Nakamura, N., Kaneda, Y. and Rabinovitch, M. Gene transfer in utero biologically engineers a patent ductus arteriosus in lambs by arresting fibronectin-dependent neointimal formation. Nat. Med. 5:176-82, 1999
  6. Robson, P. Stein, P., Zhou, B., Schultz, R. and Baldwin, H.S. Inner cell mass-specific expression of a cell adhesion molecule (PECAM-1/CD31) in the mouse blastocyst. Dev. Biol.  234:317-329, 2001
  7. Cron RQ, Zhou B., Brunvand M.W., Lewis D.B. Octamer proteins inhibit IL-4 gene transcription in normal human CD4 T cells. Genes Immun. 2:464-8, 2001
  8. Zhou, B., Cron, R.Q. Wu, B., Genin, A., Wang, Z., Liu S., Robson, P. and Baldwin, H.S. NFATc1 expression is increased by NFATc2 during T cell activation. J. Biol. Chem. 277:10704-11, 2002. PMID: 11786533
  9. Phoon C.K.L., Ji, R-P., Aristizábal, O., Worrad, D.M., Wu, B., Zhou, B., Baldwin, H.S. and Turnbull, D.H. Embryonic heart failure in NFATc1-/- mice: novel mechanistic insights from in utero ultrasound biomicroscopy. Circ. Res. 95:92-9. 2004
  10. Zhou, B.*, Wu, B., Tompkins, K.L., Boyer, K.L., Grindley, J.C., and Baldwin, H.S. Characterization of NFATc1 regulation identifies an enhancer required for gene expression that is specific to pro-valve endocardial cells in the developing heart. Development 132:1137-1146. 2005. PMID: 15689382 *Corresponding author
  11.  Chen J-W., Zhou, B.*, Shin, J., Schneider, M.D. H., Baldwin H.S., and Bergelson, J.M. Cardiomyocyte-Specific expression of the coxsackievirus and adenovirus receptor is essential for normal left ventricular development. Circ Res. 98:923-30. 2006. PMID: 16543498 *Co-first author
  12. Kim, K., Lee, J., Kim, J.H., Jin, H.M., Zhou, B., Lee, S.Y. and Kim, N. Protein Inhibitor of Activated STAT 3 Modulates Osteoclastogenesis by Down-Regulation of NFATc1 and Osteoclast-Associated Receptor J. Immunol. 178(9):5588-94, 2007. PMID: 17442941
  13. Wu, H., Kao, S-C., Barrientos, T., Baldwin, H.S., Olson, E.N., Crabtree, G.R., Zhou, B. and Chang, C-P. ‘DSCR1 is a transcriptional target of NFATc1 within the endocardium during heart development’ J. Biol. Chem. 282:30673-9, 2007. PMCID: 2366997
  14. Cann, G.M. Guignabert, C., Ying, L., Deshpande, N., Powers, J.M., Wang, L., Zhou, B., and Rabinovitch, M.  Developmental Expression of LC3a and b: Absence of Fibronectin or Autophagy Phenotype in LC3b Knockout Mice.  Dev. Dyn. 237:187-95, 2008. PMID: 18069693
  15. Langworthy, M., Zhou, B., de Caestecker, M., Moeckel G., and Baldwin, H.S. NFATc1 Identifies a Population of Proximal Tubule Cell Progenitors J. Am. Soc. Nephrol. 20:311-21. 2009. PMCID: 2637056
  16. Ying, L., Lau, A, Alvira, C.M., West R., Cann G.M., Zhou, B., Kinnear, C., Jan, E., Sarnow, P., Van de Rijn, M., and Rabinovitch, M. LC3 Mediated Fibronectin mRNA Translation Induces Fibrosarcoma Growthby Increasing Connective Tissue Growth Factor. J. Cell Sci. 122:1441-5, 2009. PMCID: 2672968
  17. Zhou, B., Ma, Q., Kong, S.W., Hu, Y., Campbell, P.H., McGowan, F.X., Ackerman, K.G., Wu, B., Zhou, B., Tevosian S.G., and Pu, W.T. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J. Clin. Invest. 119(6):1462-76, 2009. PMCID: 2689123
  18. Torgerson， T.R., Genin,J., Chen, C., Zhang,M., Zhou, B., Anover-Sombke, S., Barton Frank, M., Dozmorov, I., Ocheltree, E., Kulmala, P., Centola, M. Ochs, H.D., Wells, A.D., and Cron, R.Q. FOXP3 Inhibits Activation-Induced NFAT2 Expression in T Cells Thereby Limiting Effector Cytokine Expression1. J. Immuol. 183(2):907-15, 2009. PMCID: 2778477
  19. Zeini M., Hang C-T, Lehrer-Graiwer, J., Zhou, B., and Chang C-P. Endothelial calcineurin-NFAT signaling functions within a narrow developmental window to regulate coronary vascular patterning. Development 136:3335-45, 2009
  20. 20.  Wu, B., Zhou, B., Wang, Y., Cheng H-L, Hang, C.T., Pu, W.T., Chang, C-P and Zhou, B. Inducible cardiomyocyte-specific gene disruption directed by the rat Tnnt2 promoter in the mouse. Genesis 48:63-72, 2010. PMID: 20014345
  21. Hang, CT, Yang, J, Han, P, Cheng, HL, Shang, C, Ashley, E, Zhou, B, Chang, CP. Chromatin regulation by Brg1 underlies heart muscle development and disease. Nature 466:62-7, 2010. PMCID: 2898892
  22. Song, L., Zhao, M., Wu, B., Zhou, B., Wang, Q., and Jiao, K. Cell Autonomous Requirement of Endocardial Smad4 during Atrioventricular Cushion Development in Mouse Embryos. Developmental Dynamics 240:211-220, 2011. PMID: 21089072
  23. Wu, B., Wang, Y., Lui, W., Langworthy, M., Tompkins, K.L., Hatzopoulos, A.K., Baldwin, H.S., Zhou, B. Nfatc1 Coordinates Valve Endocardial Cell Lineage Development Required for Heart Valve Formation. Circ. Res. 2011 May 19 [Epub ahead of print] NIHMSID: 299095. PMID: 21597012

 

 

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Contact

Albert Einstein College of Medicine
Michael F. Price Center
1301 Morris Park Avenue , Room 420
Bronx, NY 10461

Tel: 718.678.1067
Fax: 718.678.1016
bin.zhou@einstein.yu.edu

 
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