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Faculty Profile

Bryen A. Jordan, Ph.D.

Dr. Bryen A. Jordan

Assistant Professor, Dominick P. Purpura Department of Neuroscience

Assistant Professor, Department of Psychiatry and Behavioral Sciences

 

Professional Interests

Exploring synaptic function and activity-dependent synapse-to-nucleus signaling

 

One of the principal questions in neuroscience is how does neuronal activity alter synaptic transmission.  This question is critically important since activity-dependent changes in neurotransmission are the underlying processes regulating higher order brain functions such as learning and memory.  Our lab is interested in understanding how do transient changes in synaptic neurotransmission become long-term. Specifically we are interested in exploring activity-dependent synapse-to-nucleus signaling in neurons. The activity-dependent regulation of nuclear functions is essential for the long-term maintenance of synaptic strengthening and the storage of memories.  While the nature of this signaling pathway is widely debated, it is well known that neuronal activity results in the rapid nuclear accumulation of many proteins, including AIDA-1, Jacob, NFATc4 and NF-kB, suggesting this may be a mechanism in nuclear signaling. We seek to understand how synapses relay fast synaptic information to the nucleus and specifically what are the key players in this process, what signals they respond to and what are their nuclear functions. To study this, we use proteomics and mass spectrometry to explore the composition and dynamics of excitatory synapses and nuclei. These methods provide us with a global view of synaptic complexity as well as help us identify novel components of synapse-to-nucleus signaling mechanisms, which we can then further study using reductionist methods in cell and molecular biology as well as biochemistry and imaging analysis.  Using these methods we found that a number of synaptic components can shuttle to the nucleus in response to synaptic activity.   We also found that a number of nuclear proteins are incorporated into the synapse in response to synaptic activity suggesting that the reverse pathway, nucleus-to-signaling pathway regulates synaptic function.  Our immediate goal is to study these novel synapse to nucleus signaling messengers and to explore their synaptic and nuclear functions.   

 

Selected Publications

Jordan BA., Fernholz BD., Khatri L., Ziff EB. NMDA receptor-dependent AIDA-1 synapse-to-nucleus signaling regulates nucleolar number in neurons. Nat. Neurosci. 2007 Apr; 10(4):427-35

 

Jordan BA, Ziff EB.  To the Nucleus with Proteomics. In Regulation of Transcription by Neuronal Activity. Edited by: Dudek SM. Springer Science; November 2007

 

Jordan BA., Ziff EB. Getting to synaptic complexes through systems biology.  Genome Biology, 2006 7:214. doi:10.1186/gb-2006-7-4-214

 

Monea, S., Jordan BA., Srivastava S., DeSouza S., and Ziff EB.  Membrane Localization of Membrane Type 5 Matrix Metalloproteinase by AMPA Receptor Binding Protein and Cleavage of Cadherins. J. Neurosci. 2006 26: 2300-2312

 

Jordan BA, Fernholz BD, Neubert TA, Ziff EB: New tricks for an old dog: proteomics of the PSD. In The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology. Volume 29. Edited by: Kittler JT, Moss SJ. Boca Raton: CRC/Taylor & Francis; 2006:37-55.

 

Jordan, BA., Fernholz, BD., Boussac, M., Xu, C., Grigorean, G., Ziff, EB., and Neubert, TA. Identification and Verification of Novel Rodent Postsynaptic Density Proteins. Mol. Cell. Proteomics, 2004: 3(9):857-71

 

Jordan BA, Gomes I, Rios CD, Filipovska J, Devi L.  mu opioid and a2a-adrenergic receptor interactions in neurons.  Mol Pharm 2003; 64(6) 1317-1324

 

Gomes I, Filipovska J, Jordan BA, Devi LA.  Oligomerization of opioid receptors. Methods 27 (4): 358-365 Aug 2002

 

Rios CD, Jordan BA, Gomes I, and Devi LA.  G-protein-coupled receptor dimerization: modulation of receptor function. Pharmacol Therapeut 92 (2-3): 71-87 Nov-Dec 2001 

 

Gomes I, Jordan BA, Gupta A, Rios C, Trapaidze N, Devi LA.  G protein coupled receptor dimerization: implications in modulating receptor function. Journal of Mol Med 79 (5-6): 226-242 Jun 2001

 

Jordan, BA., Trapaidze, N., Gomes, I., Nivarthi, R., and Devi, L. Opioid receptors heterodimerize with beta-adrenergic receptors: A role in trafficking and MAPK activation. PNAS 2001; 98(1): 343-348.

 

Gomes, I., Jordan, BA., Nagy, V., Trapaidze, N., Bansinath, M., and Devi, L.Interaction between Mu and Delta opioid receptors: A role for dimerization in opioid receptor cross-talk, J. Neurosci. 2000; 20: RC110

 

Jordan, BA., Cvejic, S., and Devi, L. Opioids and their complicated receptor complexes,  Neuropsychopharmacology. 2000; 19, 19-27

 

Jordan, BA., Cvejic, S., and Devi, L. Kappa opioid receptor endocytosis by dynorphin peptides, DNA Cell Biol. 2000; 19, 19-27

 

Jordan, BA., and Devi, L. G protein coupled receptor heterodimerization modulates receptor function, Nature 1999; 399, 697-700

 

Jordan, B., and Devi, L. Molecular mechanisms of opioid receptor signal transduction, Br J Anaesth. 1998; 81, 12-19

 

Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.

Contact

Albert Einstein College of Medicine
Rose F. Kennedy Center
1410 Pelham Parkway South , Room 825
Bronx, NY 10461

Tel: 718.430.8821
bryen.jordan@einstein.yu.edu

 
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