Faculty Profile

Dr. Johanna M. Van Oers, Ph.D.

Johanna M. Van Oers, Ph.D.

Associate, Department of Cell Biology

Professional Interests

My research interests are directed toward understanding the role of DNA repair and subsequent genomic instability in early intestinal tumorigenesis. Specifically, I aim to unravel early genetic events in repair-deficient intestinal stem cells. My work combines a genetic approach with cell biological techniques. I'm currently using genetic mouse models of repair to induce genomic instability in intestinal stem cells, and use my extensive experience in intestinal crypt culture and stem cell sorting to assess genetic targets of instability in vivo and in vitro. In addition, I will study the effect of dietary carcinogens on repair-deficient intestinal stem cells and subsequent intestinal tumorigenesis in order to advance colorectal cancer prevention and treatment.

Selected Publications

Will B, Vogler TO, Narayanagari S, Bartholdy B, Todorova TI, da Silva Ferreira M, Chen J, Yu Y, Mayer J, Barreyro L, Carvajal L, Neriah DB, Roth M, van Oers JMM, Schaetzlein S, McMahon C, Edelmann W, Verma A, Steidl U (2015). Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia. Nature Med 21:1172-1181.

Dietlein F, Thelen L, Jokic M, Jachimowicz RD, Ivan L, Knittel G, Leeser U, van Oers JMM, Edelmann W, Heukamp LC, Reinhardt HC (2014). A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDC. Cancer Discov 5:592-605.

van Oers JMM, Edwards Y, Chahwan R, Zhang W, Smith C, Pechuan J, Schaetzlein S, Jin B, Wang Y, Sellers RS, Bergman A, Scharff MD, Edelmann W (2014). The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both double strand break repair and mismatch repair. Oncogene 33:3939-3946.

Chahwan R, van Oers JMM, Avdievich E, Zhao C, Edelmann W, Scharff MD, Roa S (2012). The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination. J Exp Med209:671-678.

van Oers JMM*, Roa S*, Werling U, Liu Y, Genschel J, Hou H, Sellers R, Modrich P, Scharff MD, Edelmann W (2010). PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance. Proc Natl Acad Sci USA 107:13384-13389.

Hafner C, Stoehr R, van Oers JMM, Zwarthoff EC, Hofstaedter F, Klein C, Landthaler M, Hartmann A, Vogt T (2009). The absence of BRAF, FGFR3, and PIK3CA mutations differentiates lentigo simplex from melanocytic nevus and solar lentigo. J Invest Dermatol129:2730-2735.

Hafner C, Stoehr R, van Oers JMM, Zwarthoff EC, Hofstaedter F, Landthaler M, Hartmann A, Vogt T (2009). FGFR3 and PIK3CA mutations are involved in the molecular pathogenesis of solar lentigo. Br J Dermatol 160:546-551.

van Oers JMM, Zwarthoff EC, Rehman I, Azzouzi A, Cussenot O, Meuth M, Hamdy FC, Catto JWF (2009). FGFR3 mutations indicate better survival in invasive upper urinary tract and bladder tumours. Eur Urol 55:650-657.

Burger M, van der Aa MNM, van Oers JMM, Brinkman A, van der Kwast TH, Steyerberg EW, Stoehr R, Kirkels WJ, Denzinger S, Wild PJ, Wieland WF, Hofstaedter F, Hartmann A, Zwarthoff EC (2008). Prediction of progression of non-muscle invasive bladder cancer by WHO 1973 and 2004 grading and by FGFR3 mutation status: a prospective study. Eur Urol 54:835-843.

Junker K*, van Oers JMM*, Zwarthoff EC, Kania I, Schubert J, Hartmann A (2008). Fibroblast growth factor receptor 3 mutations in bladder tumors correlate with low frequency of chromosome alterations. Neoplasia 10:1-7.

Hafner C, Hartmann A, van Oers JMM, Stoehr R, Zwarthoff EC, Hofstaedter F, Landthaler M, Vogt T (2007). FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization. Mod Pathol 20:895-903.

Eiber M, van Oers JMM, Blaszyk H, Zwarthoff EC, van der Kwast TH, Stoehr R, Burger M, Cheville JC, Sauter G, Amin M, Hofstaedter F, Hartmann A (2007). Low frequency of molecular changes and tumor recurrence in inverted papillomas of the urinary tract. Am J Surg Pathol31:938-946.

van Oers JMM, Wild PJ, Burger M, Denzinger S, Stoehr R, Rosskopf E, Hofstaedter F, Steyerberg EW, Klinkhammer-Schalke M, Zwarthoff EC, van der Kwast TH, Hartmann A (2007). FGFR3 mutations and a normal CK20 staing pattern define low-grade noninvasive urothelial bladder tumours. Eur Urol52:760-768.

Wild PJ, Giedl J, Stoehr R, Junker K, Boehm S, van Oers JMM, Zwarthoff EC, Blaszyk H, Fine SW, Humphrey PA, Dehner LP, Amin MB, Epstein JI, Hartmann A (2007). Genomic aberrations are rare in urothelial neoplasms of patients 19 years or younger. J Pathol 211:18-25.

Hafner C, van Oers JMM, Hartmann A, Landthaler M, Stoehr R, Blaszyk H, Hofstaedter F, Zwarthoff EC, Vogt T (2006). High frequency of FGFR3 mutations in adenoid seborrheic keratoses. J Invest Dermatol 126:2404-2407.

Hafner C, van Oers JMM, Vogt T, Landthaler M, Stoehr R, Hofstaedter F, Zwarthoff EC, Hartmann A (2006). Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi. J Clinical Invest 116:2201-2207.

van Oers JMM, Adam C, Denzinger S, Stoehr R, Bertz S, Zaak D, Stief C, Hofstaedter F, Zwarthoff EC, van der Kwast TH, Knuechel R, Hartmann A (2006). Chromosome 9 deletions are more frequent than FGFR3 mutations in flat urothelial hyperplasias of the bladder. Int J Cancer 119:1212-1215.

van Oers JMM, Lurkin I, van Exsel AJA, Nijsen Y, van Rhijn BWG, van der Aa MNM, Zwarthoff EC (2005). A simple and fast method for the simultaneous detection of nine fibroblast growth factor receptor 3 mutations in bladder cancer and voided urine. Clin Cancer Res 11:7743-7748.

Slager EH, van der Minne CE, Goudsmit J, van Oers JMM, Kostense S, Havenga MJ, Osanto S, Griffioen M (2004). Induction of CAMEL/NY-ESO-ORF2-specific CD8+ T cells upon stimulation with dendritic cells infected with a modified Ad5 vector expressing a chimeric Ad5/35 fiber. Cancer Gene Ther 11:227-236.

 

 

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Research Information