Faculty Profile

Dr. Pooja Arora, Ph.D.

Pooja Arora, Ph.D.

Associate, Department of Microbiology & Immunology

Selected Publications

Peer-Reviewed and Original Communications(* Equal Authorship)

  1. Trivedi OA, Arora P, Sridharan V, Tickoo R, Mohanty D, Gokhale RS. Enzymic activation and transfer of fatty acids as acyl-adenylates in mycobacteria.  Nature. 2004 Mar 25;428(6981):441-5.
  2. Trivedi OA, Arora P, Vats A, Ansari MZ, Tickoo R, Sridharan V, Mohanty D, Gokhale RS. Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid. Mol Cell. 2005 Mar 4;17(5):631-43.
  3. Arora P, Vats A, Saxena P, Mohanty D, Gokhale RS. Promiscuous fatty acyl CoA ligases produce acyl-CoA and acyl-SNAC precursors for polyketide biosynthesis. J Am Chem Soc. 2005 Jul 6;127(26):9388-9.
  4. Goyal A, Yousuf M, Rajakumara E, Arora P, Gokhale RS, Sankaranarayanan R. Crystallization and preliminary X-ray crystallographic studies of the N-terminal domain of FadD28, a fatty-acyl AMP ligase from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Apr 1;62(Pt 4):350-2.
  5. Pearce MJ, Arora P, Festa RA, Butler-Wu SM, Gokhale RS, Darwin KH. Identification of substrates of the Mycobacterium tuberculosis proteasome. EMBO J. 2006 Nov 15;25(22):5423-32.
  6. Arora P, Porcelli SA. A glycan shield for bacterial sphingolipids. Chem Biol. 2008 Jul 21;15(7):642-4.
  7. Arora P*, Goyal A*, Natarajan VT, Rajakumara E, Verma P, Gupta R, Yousuf M, Trivedi OA, Mohanty D, Tyagi A, Sankaranarayanan R, Gokhale RS. Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis. Nat Chem Biol. 2009 Mar;5(3):166-73.
  8. Im JS*, Arora P*, Bricard G, Molano A, Venkataswamy MM, Baine I, Jerud ES, Goldberg MF, Baena A, Yu KO, Ndonye RM, Howell AR, Yuan W, Cresswell P, Chang YT, Illarionov PA, Besra GS, Porcelli SA. Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation. Immunity. 2009 Jun 19;30(6):888-98.
  9. Arora P, Venkataswamy MM, Baena A, Bricard G, Li Q, Veerapen N, Ndonye R, Park JJ, Lee JH, Seo KC, Howell AR, Chang YT, Illarionov PA, Besra GS, Chung SK, Porcelli SA. A rapid fluorescence-based assay for classification of iNKT cell activating glycolipids. J Am Chem Soc. 2011 Apr 13;133(14):5198-201.
  10. Tyznik AJ, Farber E, Girardi E, Birkholz A, Li Y, Chitale S, So R, Arora P, Khurana A, Wang J, Porcelli SA, Zajonc DM, Kronenberg M, Howell AR. Glycolipids that elicit IFN-γ-biased responses from natural killer T cells. Chem Biol. 2011 Dec 23;18(12):1620-30.
  11. Arora P, Foster EL, Porcelli SA. CD1d and natural killer T cells in immunity to Mycobacterium tuberculosis. Adv Exp Med Biol. 2013;783:199-223.
  12. Arora P, BaenaA, YuKO, SainiNK, Kharkwal SS, GoldbergMF, Kunnath-VelayudhanS, CarreñoLJ, VenkataswamyMM, KimJ, Lazar-MolnarE, LauvauG, Chang YT, Liu Z, Bittman R, Al-Shamkhani A, Cox LR, Jervis PJ, Veerapen N, Besra GS, Porcelli, SA.  A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens. Immunity. 2014 Jan, 10.1016/j.immuni.2013.12.004 19;30(6):888-98.

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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
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Bronx, NY 10461

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Research Information