Associate Professor, Department of Microbiology & Immunology
Activation of the innate immune system is essential for effective eradication of invading pathogens. Dendritic cell (DC) activation plays a central role in these responses. DCs reside at all mucosal surfaces and act as ëimmunological sensorsí by sampling invading pathogens. Pathogen recognition results in DC activation and their egress to the local lymph nodes where they alert lymphocytes (adaptive immune response) to respond. Understanding how the innate immune system responds to microbial infections will provide us with novel strategies to tackle these invaders. In addition, identification of microbial components that activate immunity in the absence of pathology (known as adjuvants) can be used to build more effective vaccines. Vaccines for measles, diphtheria and tetanus confer good protection whilst others, such as those for influenza, are not very effective. Suboptimal responses can often be attributed to absence of adjuvant activity in the attenuated vaccine. Certain pathogen components can act as adjuvants and can activate DCs as effectively as the whole organism from which they are derived.
Our aim is to assess the role of novel genes involved in dendritic cell activation using in vitro and in vivo and RNA interference (RNAi)-based approaches.
More Information About Dr. Deborah Palliser
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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Forchheimer Building, Room 403
Bronx, NY 10461
Reuters cites research by Dr. Deborah Palliser on an experimental liquid that shows long-acting protection against genital herpes. Dr. Palliser is an assistant professor of microbiology & immunology. The finding appears in the latest edition of Cell Host & Microbe.