Associate, Department of Microbiology & Immunology
I am interested in environmentally dependent regulation of bacterial gene expression and survival mechanisms of tuberculosis bacilli. I am specifically focused on the problem of persistence, the ability of small populations of tuberculosis bacilli to survive antibiotic treatment despite lacking alleles that code for genotypic drug resistance. The phenomenon of persistence may be the basis of the need for lengthy treatment regimens to cure tuberculosis and could also contribute the ability of the bacteria to establish a latent infection. I have characterized the transcriptome of tuberculosis persister cells to identify genes that may be involved in the phenomenon, and have created mutant strains defective for persistence. I am in the process of characterizing these mutants using mouse models and various -omics technologies and work collaboratively on other projects that require systems biological approaches.
Jain P*, Weinrick BC*, Kalivoda EJ, Yang H, Munsamy V, Vilchèze C, Weisbrod T, Larsen MH, O’Donnell MR, Pym A, Jacobs WR Jr. Dual-Reporter Mycobacteriophages (Φ2DRMs) Reveal Pre-existing Mycobacterium tuberculosis Persistent Cells in Human Sputum. MBio. 2016 in press. *equal contribution
Petro CD, Weinrick B, Khajoueinejad N, Burn C, Sellers R, Jacobs WR Jr, Herold BC. HSV-2 ∆gD Elicits FcγR-Effector Antibodies that Protect Against Clinical Isolates. JCI Insight. 2016 Aug 4;1(12):e88529.
Prados-Rosales R, Carreño LJ, Weinrick B, Batista-Gonzalez A, Glatman-Freedman A, Xu J, Chan J, Jacobs WR Jr, Porcelli SA, Casadevall A.The Type of Growth Medium Affects the Presence of a Mycobacterial Capsule and Is Associated With Differences in Protective Efficacy of BCG Vaccination Against Mycobacterium tuberculosis. J Infect Dis. 2016 Apr 18.
Packiam M, Weinrick B, Jacobs Jr. WR, Maurelli AT. Structural characterization of muropeptides from Chlamydia trachomatis peptidoglycan by mass spectrometry resolves "chlamydial anomaly". Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11660-5.
Chandrabos C, M'Homa Soudja S, Weinrick B, Gros M, Frangaj A, et al. The p60 and NamA autolysins from Listeria monocytogenes contribute to host colonization and induction of protective memory. Cell Microbiol. 2015 Feb;17(2):147-63.
Hartman T, Weinrick B, Vilchèze C, Berney M, Tufariello J, et al. Succinate dehydrogenase is the regulator of respiration in Mycobacterium tuberculosis. PLoS Pathog. 2014 Nov;10(11):e1004510
Vilchèze C, Molle V, Carrère-Kremer S, Leiba J, Mourey L, et al. Phosphorylation of KasB regulates virulence and acid-fastness in Mycobacterium tuberculosis. PLoS Pathog. 2014 May;10(5):e1004115.
Prados-Rosales R, Weinrick BC, Piqué DG, Jacobs WR Jr, Casadevall A, Rodriguez GM. A role for Mycobacterium tuberculosis membrane vesicles in iron acquisition. J Bacteriol. 2014 Mar;196(6):1250-6.
Wang F, Sambandan D, Halder R, Wang J, Batt SM, Weinrick B, Ahmad I, Yang P, Zhang Y, Kim J, Hassani M, Huszar S, Trefzer C, Ma Z, Kaneko T, Mdluli KE, Franzblau S, Chatterjee AK, Johnson K, Mikusova K, Besra GS, Fütterer K, Jacobs WR Jr, Schultz PG. Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc Natl Acad Sci U S A. 2013 Jun 17.
Vilchèze C, Hartman T, Weinrick B, Jacobs WR Jr. Mycobacterium tuberculosis is extraordinarily sensitive to killing by a vitamin C-induced Fenton reaction. Nat Commun. 2013; 4:1881.
Sambandan D, Dao DN, Weinrick BC, Vilchèze C, Gurcha SS, Ojha A, Kremer L, Besra GS, Hatfull GF, Jacobs WR Jr. Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive Mycobacterium tuberculosis. MBio. 2013 May 7; 4(3).
Kalscheuer R, Weinrick B, Veeraraghavan U, Besra GS, Jacobs WR Jr. Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2010 Dec 14; 107 (50): 21761-6.
Kalscheuer R, Syson K, Veeraraghavan U, Weinrick B, Biermann KE, Liu Z, Sacchettini JC, Besra G, Bornemann S, Jacobs WR Jr. Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway. Nat Chem Biol. 2010 May; 6 (5): 376-84.
Vilchèze C, Weinrick B, Wong KW, Chen B, Jacobs WR Jr. NAD+ auxotrophy is bacteriocidal for the tubercle bacilli. Mol Microbiol. 2010 Apr; 76 (2): 365-77.
Waters WR, Palmer MV, Nonnecke BJ, Thacker TC, Scherer CF, Estes DM, Hewinson RG, Vordermeier HM, Barnes SW, Federe GC, Walker JR, Glynne RJ, Hsu T, Weinrick B, Biermann K, Larsen MH, Jacobs WR Jr. Efficacy and immunogenicity of Mycobacterium bovis DeltaRD1 against aerosol M bovis infection in neonatal calves. Vaccine. 2009 Feb 18; 27 (8): 1201-9.
Weinrick B, Dunman PM, McAleese F, Murphy E, Projan SJ, Fang Y, Novick RP. Effect of mild acid on gene expression in Staphylococcus aureus. J Bacteriol. 2004 Dec; 186 (24): 8407-23.
Limbago B, McIver KS, Penumalli V, Weinrick B, Scott JR. Restoration of Mga function to a Streptococcus pyogenes strain (M Type 50) that is virulent in mice. Infect Immun. 2001 Feb; 69 (2): 1215-20.
Limbago B, Penumalli V, Weinrick B, Scott JR. Role of streptolysin O in a mouse model of invasive group A streptococcal disease. Infect Immun. 2000 Nov; 68 (11): 6384-90.
More Information About Dr. Brian Weinrick
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Albert Einstein College of Medicine
Jack and Pearl Resnick Campus
1300 Morris Park Avenue
Ullmann Building, Room 115
Bronx, NY 10461