Faculty Profile

Dr. Michal L. Melamed, M.D.

Michal L. Melamed, M.D.

Associate Professor, Department of Medicine (Nephrology)

Associate Professor, Department of Epidemiology & Population Health

Areas of Research: Risk factors for chronic kidney disease (CKD) and acute kidney injury (AKI); racial disparities in kidney disease; clinical trials of bicarbonate therapy, vitamin D, group care; vitamin D deficiency and outcomes

Professional Interests

Dr. Michal Melamed is an Associate Professor of Medicine and Epidemiology & Population Health at the Albert Einstein College of Medicine.  She has served as the Director of Residency Research and Fellowship Guidance since 2014. She has been the Nephrology Fellowship Program Director since 2012. After completing her undergraduate degree in Dramatic Literature at New York University summa cum laude, she trained at Johns Hopkins School of Medicine for medical school, Internal Medicine residency, and Nephrology fellowship. Additionally, she completed a Masters in Clinical Epidemiology from the Johns Hopkins Bloomberg School of Public Health during her fellowship.

She has been continuously funded by the National Institutes of Health since 2007 and her research interests include the epidemiology of and ethnic and racial disparities in chronic kidney disease and its complications, the epidemiology and health consequences of Vitamin D deficiency and acute kidney injury. Dr. Melamed is the Principal Investigator of several NIH-funded research studies including studies on vitamin D therapy and the use of group-based care in CKD.  


Selected Publications

Fine DM, Gelber AC, Melamed ML, Lin JC, Zhang L, Eustace JA. Risk factors for renal failure among 72 consecutive patients with rhabdomyolysis related to illicit drug use. Am J Med. 2004 Oct 15;117(8):607-10.
Melamed ML, Kim HS, Jaar BG, Molmenti E, Atta MG, Samaniego MD. Combined percutaneous mechanical and chemical thrombectomy for renal vein thrombosis in kidney transplant recipients. Am J Transplant. 2005 Mar;5(3):621-6.
Powe NR, Melamed ML.Racial Disparities in the Optimal Delivery of Chronic Kidney Disease Care. Med Clin North Am. 2005 May;89(3):475-488.
Melamed ML, Eustace JA, Plantinga L, Jaar BG, Fink NE, Klag MJ, Coresh J, Powe NR. Changes in Serum Calcium, Phosphate and PTH and the Risk of Death in Incident Dialysis Patients: A Longitudinal Study. Kidney Int 2006 Jul;70(2):351-7.
Gupta R, Plantinga LC, Fink NE, Melamed ML, Coresh J, Fox CS, Levin NW, Powe NR. Statin use and hospitalization for sepsis in patients with chronic kidney disease. JAMA 2007 Apr 4;297(13):1455-64.
Hailpern SM, Melamed ML, Cohen HW, Hostetter T.  Moderate Chronic Kidney Disease and Cognitive Function in Adults 20-59 Years of Age (NHANES III). J Am Soc Nephrol 2007 Jul;18(7):2205-13.
Melamed ML, Eustace JA, Plantinga LC, Jaar BG, Fink NE, Parekh RS, Coresh J, Yang Z, Cantor T, Powe NR. Third-Generation Parathyroid Hormone Assays and All-Cause Mortality in Incident Dialysis Patients: The CHOICE Study. Nephrol Dial Transplant. 2008 May; 23(5):1650-8.
Michos ED, Melamed ML. Vitamin D and cardiovascular disease risk. Curr Opin Clin Nutr Metab Care. 2008 Jan;11:1:7-12.
Bauer C, Melamed ML, Hostetter TH. Staging of Chronic Kidney Disease: Time for a Course Correction. J Am Soc Nephr 2008 May;19(5):844-6.
Raff AC, Lieu S, Melamed ML, Quan Z, Ponda M, Meyer TW, Hostetter TH. Relationship of Impaired Olfactory Function in ESRD to Malnutrition and Retained Uremic Molecules. Am J Kidney Dis. 2008 Jul;52(1):102-110.
Wolf M, Betancourt J, Chang Y, Shah A, Teng M, Tamez H, Camargo CA, Melamed M, Norris K, Stampfer MJ, Powe NR, Thadhani R. Impact of Activated Vitamin D and Race on Hemodialysis Survival. J Am Soc Nephrol 2008 Jul;19(7)1379-88.
Huang CX, Plantinga LC, Fink NE, MelamedML, Coresh J, Powe NR. Phosphate Levels and Blood Pressure in Incident Hemodialysis Patients: A Longitudinal Study. Adv in Chronic Kidney Dis. 2008 Jul;15(3):321-31.
Melamed ML, Bauer C, Hostetter TH. eGFR: is it ready for early identification of CKD? Clin J Am Soc Nephrol. 2008 Sep;3(5):1569-72.
Melamed ML*, Muntner P*, Michos ED, Uribarri J, Weber C, Sharma J, Raggi P. Serum 25-hydroxyvitamin D Levels and the Prevalence of Peripheral Arterial Disease: Results from NHANES 2001-2004. Atheroscler Thromb Vasc Biol. 2008 Jun;28(6)1179-85.
Plantinga LC, Fink NE, Melamed ML, Briggs WA, Powe NR, Jaar BG. Serum Phosphate Levels and the Risk of Infection in Incident Dialysis Patients. Clin J Am Soc Nephrol. 2008 Sep;3(5):1398-406.
Melamed ML*, Michos ED*, Post W, Astor B. 25-Hydroxyl Vitamin D Levels and the Risk of Mortality in the General Population. Arch Intern Med. 2008 Aug 11;168(15):1629-37.
Muntner P, Jones TM, Hyre AD, Melamed ML, Alper A, Raggi P, Leonard MB. Elevated serum intact parathyroid hormone associated with decreased estimated glomerular filtration rate. Clin J Am Soc Nephrol 2009 Jan;4(1):186-94. Epub 2008 Nov 19.
Shah S, Abramowitz M, Hostetter TH, Melamed ML. Serum Bicarbonate Levels and the Progression of Kidney Disease: A Cohort Study. Am J Kidney Dis. 2009 Aug;54(2):270-7.
Melamed ML, Thadhani R. Low calcidiol levels and coronary artery calcification: true, true and related? J Am Soc Nephrol. 2009 Aug;20(8):1663-5
Kumar J, Muntner P, Kaskel FJ, Hailpern SM, Melamed ML. Prevalence and Associations of 25- Hydroxyvitamin D Deficiency in Children and Adolescents in the United States: Results from NHANES 2001-2004. Pediatrics. Aug 3 2009. Electronic pages.
Plantinga LC, Fink NE, Coresh J, Sozio SM, Parekh RS, Melamed ML, Powe NR, Jaar BG. Peripheral vascular disease-related procedures in dialysis patients: predictors and prognosis. Clin J Am Soc Nephrol. 2009 Oct;4 (10):1637-45.
Golestaneh L, Melamed ML, Hostetter TH. Uremic memory: the role of acute kidney injury in long-term outcomes. Kidney Int. 2009 Oct: 76(8):813-4.
Tonelli M, Curhan G, Pfeffer M, Sacks F, Thadhani R, Melamed ML, Wiebe N, Muntner P. Relation Between Alkaline Phosphatase, Serum Phosphate, and All-Cause or Cardiovascular Mortality. Circulation. 2009 Oct. 19 Epub. 2009 Nov 3;120(18):1784-92.
Melamed ML, Astor B, Michos ED, Hostetter TH, Powe NR, Muntner P. 25-Hydroxyvitamin D levels, Race and the Progression of Kidney Disease. J Am Soc Nephrol. 2009 Dec.;20(12) 2631-9.
Abramowitz M, Muntner P, Coco M, Southern W, Lotwin I, Hostetter TH, Melamed ML. Serum alkaline phosphatase and phosphate and risk of mortality and hospitalization. Clin J Am Soc Nephrol. 2010 Apr 8 Epub. 2010 Jun;5(6):1064-71.
Millen AE, Wactawski-Wende J, Pettinger M, Melamed ML, Tylavsky FA, Liu S, Robbins J, LaCroix AZ, LeBoff MS, Jackson RD. Predictors of serum 25-hydroxyvitamin D concentrations among postmenopausal women: the Women’s Health Initiative Calcium plus Vitamin D clinical trial. Am J Clin Nutr. 2010 May; 91(5):1324-35.
Ponda MP, Quan Z, Melamed ML, Raff A, Meyer TW, Hostetter TH. Methylamine clearance by haemodialysis is low. Nephrol Dial Transplant. 2010 May; 25(5):1608-13.
Melamed ML, Kumar J. Low levels of 25-hydroxycitamin D in the pediatric populations: prevalence and clinical outcomes. Ped Health. 2010 Feb;4(1):89-97.
Murea M, Park JK, Sharma S, Kato H, Gruenwald A, Niranjan T, Si H, Thomas DB, Pullman JM, Melamed ML, Susztak K. Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function. Kidney Int. 2010 June 9; 78(5):514-22.
Melamed ML, Hostetter TH. Ionizing radiation exposure: another under recognized risk factor for poor health outcomes in dialysis patients.  Invited editorial. Kidney Int. 2010 Oct;78(8):724-5.
Melamed ML, Blackwell T, Neugarten J, Arnsten J, Ensrud K, Ishani A, Cummings S, Silbiger S. Raloxifene, a selective estrogen receptor modulator, is renoprotective: a post-hoc analysis. Kidney Int. 2011 Jan;79(2):241-9
O’ Seaghdha CM, Hwang S-J, Muntner P, Melamed ML*, Fox CS*. Serum phosphorus predicts incident Chronic Kidney Disease and End-Stage Renal Disease. Nephrol Dial Transplant 2011 Sep;26(9):2885-90. Epub 2011 Feb 3.
Abramowitz MK, Hostetter TH, Melamed ML. Association of Serum Bicarbonate Levels with Gait Speed and Quadriceps Strength in Older Adults. Am J Kidney Dis 2011 Feb 25.
Sharief S, Jariwala S, Kumar J, Muntner P, Melamed ML. Vitamin D levels and food and environmental allergies in the United States: Results from NHANES 2005-6. Journal of Allergy and Clinical Immunology 2011 May;127(5):1195-202. Epub 2011 Feb 16. PMID: 21329969
Sokol SI, Tsang P, Aggarwal V, Melamed ML, Srinivas VS. Vitamin D Status and Risk of Cardiovascular Events: Lessons Learned via Systematic Review and Meta-Analysis. Cardiol Rev. 2011 July/Aug 19(4):192-201.
Melamed ML, Manson JE. Vitamin D and cardiovascular disease and cancer: not too much and not too little? The need for clinical trials. Women’s Health. 2011 Jul;7(4):419-24.
Skversky AL, Kumar J, Abramowitz MK, Kaskel FJ, Melamed ML. Association of Glucocorticoid Use and Low 25-Hydroxyvitamin D Levels: Results from the National Health and Nutrition Examination Survey (NHANES): 2001-2006. J Clin Endocrinol Metab. 2011 Sept 28. (Epub)
Michos ED, Reis JP, Post WS, Lutsey PL, Gottesman RF, Mosley TH, Sharrett AR, Melamed ML. 25-Hydroxyvitamin D deficiency is associated with fatal stroke among whites but not blacks: The NHANES III linked mortality files. Nutrition 2012 Apr; 28(4)367-71.
Lai JY-C, Atzmon G, Melamed ML, Hostetter TH, Crandall JP, Barzilai N, Bitzer M. Family History of Exceptional Longevity is Associated with Lower Serum Uric Acid Levels. Journal of the American Geriatrics Society. 2012 Apr; 60(4):745-50, PMCID: PMC3325371.
Abramowitz MK, Hostetter TH, Melamed ML. Lower serum bicarbonate and a higher anion gap are associated with lower cardiorespiratory fitness in young adults. Kidney International. 2012 May;81(10):103342. Epub 2012 Feb 1. PMCID: PMC3340439
Turner JM, Bauer C, Abramowitz MK, Melamed ML, Hostetter TH. Treatment of chronic kidney disease. Kidney Int. 2012 Feb;81(4):351-62
Melamed ML, Thadhani RI. Vitamin D Therapy in Chronic Kidney Disease and End-Stage Renal Disease. Clin J Am Soc Nephrol. 2012 Feb;7(2)358-65. PMCID: PMC3280034
Abramowitz MK, Hostetter TH, Melamed ML. The serum anion gap is altered in early kidney disease and associates with mortality. Kidney International. 2012 Sep;82 (6):701-9.
Abramowitz MK, Melamed ML, Bauer C, Raff AC, Hostetter TH. Effects of Oral Sodium Bicarbonate in Patients with CKD. Clinical Journal of the American Society of Nephrology. 2013 Feb 7th Epub ahead of print. 2013 May; 8(5)714-20.
Berman N, Lectura M, Thurman JM, Reinecke J, Raff AC, Melamed ML, Quan Z, Evans T, Meyer TW, Hostetter TH. A Zebrafish Model for Uremic Toxicity: Role of the Complement Pathway. Blood Purif. 2013 May 8;35(4):265-269.
Melamed ML, Plantinga L, Shafi T, Parekh R, Meyer TW, Hostetter TH, Coresh J, Powe NR. Retained organic solutes, patient characteristics and all-cause and cardiovascular mortality in hemodialysis: results from the retained organic solutes and clinical outcomes (ROSCO) investigators. BMC Nephrol 2013 June 27;14(1)134.
Essien U, Goel N, Melamed ML. Role of vitamin D receptor activation in racial disparities in kidney disease outcomes. Seminars in Nephrology. 2013 Sep.; 33(5) 416-24.
Atkinson MA, Melamed ML, Kumar J, Roy CN, Miller ER 3rd, Furth SL, Fadrowski JJ. Vitamin D, Race, and Risk for Anemia in Children.  J Pediatrics. 2013 Oct 8th Epub. 164(1):153-158.
Inda Filho AJ, Melamed ML.  Vitamin D and kidney disease: what we know and what we do not know. J Bras Nrfrol. 2013: 35 (4):323-31.
Milman S, Schulder-Katz M, Deluty J, Zimmerman ME, Crandall JP, Barzilai N, Melamed ML*, Atzmon G*.  Individuals with Exceptional Longevity Manifest a Delayed Association Between Vitamin D Insufficiency and Cognitive Impairment. J Am Geriatr Soc. 2014 Jan Epub.
Akchurin OM, Melamed ML, Hashim BL, Kaskel FJ, Del Rio M. Medication adherence in the transition of adolescent kidney transplant recipients to the adult care. Pediatric Transplantation. 2014 May 12 Epub. 18(5):538-48.
Melamed ML, Manson JE. Genetics: Vitamin D and blood pressure- a preliminary verdict. Nat Rev Endocrinol. 2014 Oct; 10(10):579-80.
Chen W, Melamed ML, Abramowitz MK. Serum bicarbonate and Bone Mineral Density in US Adults. Am J Kidney Dis. 2014 Aug 26 Epub. 2015 Feb;65(2):240-8. 
Sarathy H, Pramanik V, Kahn J, Abramowitz MK, Meier K, Kishore P, Melamed ML. The Effects of Short-term Vitamin D Supplementation on Glucose Metabolism in Dialysis Patients: A Systematic Review and Meta-Analysis.  Int Urol Nephrol. 2015 Mar;47(3):537-49. 
Barry EL, Mott LA, Melamed ML, Rees JR, Ivanova A, Sandler RS, Ahnen DJ, Bresalier RS, Summers RW, Bostick RM, Baron JA. Calcium supplementation increases blood creatinine concentration in a randomized controlled trial. PLoS One. 2014. Oct 15;9(10):e108094.
Chen W, Melamed ML. Vascular Calcification in Predialysis CKD: Common and Deadly. Clin J Am Soc Nephrol. 2015;10(4)551-3.
Shafi T, Meyer TW, Hostetter TH, Melamed ML, Parekh RS, Hwang S, Banerjee T, Coresh J, Powe NR. Free levels of Selected Organic Solutes and Cardiovascular Morbidity and Mortality in Hemodialysis Patients: Results from the Retained Organic Solutes and Clinical Outcomes (ROSCO) Investigators. PLoS One. 2015 May 4;10(5)e0126048.
Scialla JJ, Parekh RS, Eustace JA, Astor BC, Plantinga L, Jaar BG, Shafi T, Coresh J, Powe NR, Melamed ML. Race, Mineral Homeostasis and Mortality in Patients with End-Stage Renal Disease on Dialysis. Am J Nephrol. 2015;42(1):25-34.
Parikh C, Gutgarts V, Eisenberg E, Melamed ML. Vitamin D and Clinical Outcomes in Dialysis. Semin Dial. 2015 Nov-Dec; 28(6):604-9.
Calp-Inal S, Ajaimy M, Melamed ML, Savchik C, Masiakos P, Colovai A, Akalin E. The prevalence and clinical significance of C1q-binding donor-specific anti-HLA antibodies early and late after kidney transplantation.  Kidney Int 2015 Nov 4 (Epub ahead of print)
Kumar J, McDermott K, Abraham AG, Friedman LA, Johnson VL, Kaskel FJ, Furth SL, Warady BA, Portale AA, Melamed ML. Prevalence and correlates of 25-hydroxyvitamin D deficiency in the Chronic Kidney Disease in Children (CKID) cohort. Pediatr Nephrol. 2016 Jan; 31(1):121-9.

Desir J, Neugarten J, Melamed M, Pullman J, Golestaneh L. Glomerular size reduction associated with severe cardiorenal syndrome.  Clin Nephrol. 2016 Jan 19 Epub ahead of print

Ricardo AC, Flessner MF, Eckfeldt JH, Eggers PW, Franceschini N, Go AS, Gotman NM, Kramer HJ, Kusek JW, Loehr LR, Melamed ML, Peralta CA, Raij L, Rosas SE, Talavera GA, Lash JP. Prevalence and Correlates of CKD in Hispanics/Latinos in the United States.  Clin J Am Soc Nephrol. 2015 Oct 7; 10(10):1757-66.

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Research Information

In the News

Reuters quotes Dr. Michal Melamed, who explains that a poor diet and lack of exercise can contribute to both obesity and kidney damage.

Reuters interviews Dr. Michal Melamed about her research that found many young, obese adults are unaware they are at risk for kidney disease.

More media coverage