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Faculty Profile

David A. D'Alessandro, M.D.

Dr. David A. D'Alessandro

Associate Professor of Clinical Cardiovascular & Thoracic Surgery, Department of Cardiovascular & Thoracic Surgery

Director, Cardiac Transplantation Program at Montefiore Medical Center, Moses & Weiler Divisions, Department of Cardiovascular & Thoracic Surgery

Director, Cardiovascular & Thoracic Surgery Clinical Trials at Montefiore Medical Center, Moses & Weiler Divisions, Department of Cardiovascular & Thoracic Surgery

Erika & Jay Abramson Dinstinguished Surgeon, Department of Cardiovascular & Thoracic Surgery


Professional Interests

David A. D’Alessandro, MD is an Associate Professor of Cardiothoracic Surgery at the Montefiore Medical Center/Albert Einstein College of Medicine in New York, New York.  He is the Surgical Director of Montefiore's Heart Transplant Program.


Before joining the Montefiore Medical Center faculty, Dr. D’Alessandro was on the faculty of the Columbia-Presbyterian Medical Center in New York where he served as a clinical instructor and an active participant in the heart transplantation and mechanical assist device programs, one of the largest such programs in the nation.


Dr. D’Alessandro received his undergraduate degree from Cornell University.  He received his medical education at the Columbia University College of Physicians and Surgeons where he was elected to the Alpha Omega Alpha Medical Honor Society.  Dr. D’Alessandro completed his residency in General Surgery, a fellowship in Renal Transplantation and a clinical and research fellowship in Cardiothoracic Surgery at the Columbia Presbyterian Medical Center in New York. 


Dr. D’Alessandro’s clinical focus has been on surgical treatments of end stage heart failure including mechanical assistance and heart transplantation.  He has a broad experience with all aspects of adult cardiothoracic surgery including on and off pump coronary artery bypass surgery, valve repair and replacement, treatment of thoracic aneurysms, and heart transplantation.  Additionally, he has extensive experience with the latest generation of mechanical assist devices and is a co-investigator in their ongoing clinical trials. 


In addition to numerous publications and scientific presentations, he was awarded a U.S. patent for a novel cardiac stabilizer with a potential application to beating heart surgery.  Dr. D’Alessandro is central figure in the Montefiore’s research effort investigating the application of endogenous stem cells for the rescue of advanced heart failure.


Selected Publications

Ashton RC, Jr., Goldstein DJ, D’Alessandro D, Weinberg AD, Burkhoff D, Rosskothen HD, Lemole GM, Oz MC. Development of an intraluminal device for the treatment of aortic regurgitation: prototype and in vitro testing system. Journal of Thoracic and Cardiovascular Surgery1996;112(4):979-983.

Dean DA, Cabreriza SE, Jia C-X, D’Alessandro DA, Sardo MJ, Chalik N, Soto PF, Dickstein ML, Spotnitz HM. Validation study of a new transit-time ultrasonic flow probe for continuous measurements of the great vessels. ASAIO 1996;42(5):M671-6

Goldstein DJ, Ashton RC, Slater JP, Pearson M, Seldomridge JA, D’Alessandro DA, Jordan DA, Oz MC. Venoarterial shunting for the treatment of right sided circulatory failure following left ventricular assist device placement. ASAIO 1997;43(3):171-6.

Landry DW, Levin HR, Gallant EM, Ashton RC Jr, Seo S, D’Alessandro D, Oz MC, Oliver JA. Vasopressin deficiency contributes to the vasodilitation of septic shock. Circulation 1997;95(5):1122-5.

Landry DW, Levin HR, Gallant EM, Seo S, D’Alessandro DA, Oz MC, Oliver JA. Vasopressin pressor hypersensitivity in vasodilatory septic shock. Critical Care Medicine 1997;25(8):1279-82.

D’Alessandro DA, Rao V, DiGiorgi PL,Oz MC. Current options for mechanical heart technology. Journal of Cardiac Surgery 2002;17(1): 81-8.

Liu EH, D’Alessandro DA, Hardy MA. Ethical issues in living renal donation. Transplant Proceedings 2003;35(3):1174-6.

Bearzi C, Rota M. Hosoda T, Tillmanns J, Nascimbene A, De Angelis A, Yasuzawa-Amano S, Trofimova I, Siggins RW, Lecapitaine N, Cascapera S, Beltrami AP, D'Alessandro DA, Zias E, Quaini F, Urbanek K, Michler RE, Bolli R, Kajstura J, Leri A, Anversa P. Human cardiac stem cells. Proceedings of the National Academy of Sciences of the United States of America 2007;104(35):14068-73.

Bearzi C, Leri A, Monaco FL, Rota M, Gonzalez A, Hosoda T,  Pepe M, Qanud K, Ojaimi C, Bardelli S, D’Amario D, D’Alessandro DA,  Michler RE, Dimmeler S, Zeiher AM, Urbanek K, Hintze TH, Kajstura J, Anversa P. Identification of a coronary vascular progenitor cell in the human heart.  Proceedings of the National Academy of Sciences of the United States of America 2009;106 (37):15885-90.

D’Alessandro DA, Kajstura J, Hosoda T, Zheng H, Bello R, Gatti A, Padin-Iruegas ME, Carvalho AB,  Mosna F, Bardelli S, Bearzi C, Rota M, Zembala MO, Stern D, Rimoldi O, Urbanek K, Michler RE, Leri A, Anversa P. Progenitor cells from the recipient generate immunocompatible myocardium within the transplanted heart. Circulation Research 2009;105(11):1128-40.

Ryan S, Chirumamilla V, Bello RA, D’Alessandro DA, Michler RE, Rabin J, Ashton RC, DeRose JJ.  How Informed is “Informed consent” for robotic cardiothoracic surgery? Innovations 2009;4(6):307-10.

Stern DR, Kazam J, Edwards P, Maybaum S, Bello RA, D’Alessandro DA, Goldstein DJ. Increased incidence of gastrointestinal bleeding following implantation of the HeartMate II LVAD. J Card Surg 2010;25:352-6.

Stern DR, Steiner C, Bello RA, Sutton N, Spevack DM, Leyvi G, Michler RE, D'Alessandro DA, Weinstein S.  Congenitally corrected transposition of the great arteries and concomitant coronary artery and valvular disease in the adult patient.  Congenital Heart Disease (2010) Nov;5(6):629-34.

D’Alessandro DA, Michler RE. Current and Future Status of Stem Cell Therapy in Heart Failure.Current Treatment Options in Cardiovascular Medicine. Curr Treat Options Cardiovasc Med. 2010;12(6):614-27.

Hosoda T, Zheng H, Cabral-de-Silva M, Sanada F, Ide-Iwata N, Ogórek B, Ferreira-Martins J, Arranto C, D’Amario D, del Monte F, Urbanek K, D’Alessandro DA, Michler RE, Anversa P, Rota M, Kajstura J, Leri A.Human cardiac stem cell differentiation is regulated by a mircrine mechanism. Circulation. 2011;123(12):1287-96.

Goichberg P, Bai Y, D'Amario D, Ferreira-Martins J, Fiorini C, Zheng H, Signore S, del Monte F, Ottolenghi S, D'Alessandro DA, Michler RE, Hosoda T, Anversa P, Kajstura J, Rota M, Leri A. The ephrin A1-EphA2 system promotes cardiac stem cell migration after infarction. Circ Res. 2011;108(9):1071-83.

D'Amario D, Cabral-Da-Silva MC, Zheng H, Fiorini C, Goichberg P, Steadman E, Ferreira-Martins J, Sanada F, Piccoli M, Cappetta D, D'Alessandro DA, Michler RE, Hosoda T, Anastasia L, Rota M, Leri A, Anversa P, Kajstura J.  Insulin-like growth factor-1 receptor identifies a pool of human cardiac stem cells with superior therapeutic potential for myocardial regeneration.  Circ Res. 2011;108(12):1467-81.

Perrault LP, Moskowitz AJ, Kron IL, Acker MA, Miller MA, Horvath KA, Thourani VH, Argenziano M, D'Alessandro DA, Blackstone EH, Moy CS, Mathew JP, Hung J, Gardner TJ, Parides MK. Optimal surgical management of severe ischemic mitral regurgitation: To repair or to replace?  J Thorac Cardiovasc Surg. 2012;143(6):1396-403.

Patel SR, D'alessandro D, Shin JJ. Combined heart and liver transplantation in an adult with familial heterozygous hypercholesterolemia and severe ischemic cardiomyopathy. J Heart Lung Transplant. 2012;31:229.

D’Alessandro DA, Forest SJ, Lamour J, Hsu D, Weinstein S, Goldstein D. First Reported Use of the HeartWare HVAD in the US as Bridge to Transplant in an Adolescent. Pediatric Transplantation (In Press).

Goldstein DJ, Bello R, Shin JJ, Stevens G, Zolty R, Maybaum S, D'Alessandro D. Outcomes of cardiac transplantation in septuagenarians. J Heart Lung Transplant. 2012;31(7):679-85.

Neragi-Miandoab S, Goldstein D, Bello R, Michler R, D'Alessandro D. Right ventricular dysfunction following continuous flow left ventriccular assist device placement in 51 patients: predicators and outcomes.  J Cardiothorac Surg. 2012;7(1):60.

Kajstura J, Rota M, Cappetta D, Ogórek B, Arranto C, Bai Y, Ferreira-Martins J, Signore S, Sanada F, Matsuda A, Kostyla J, Caballero MV, Fiorini C, D'Alessandro DA, Michler RE, Del Monte F, Hosoda T, Perrella MA, Leri A, Buchholz BA, Loscalzo J, Anversa P. Cardiomyogenesis in the aging and failing human heart. 2012;126(15):1869-81.

Kelesidis I, Yang F, Maybaum S, Goldstein D, D'Alessandro DA, Ferrick K, Kim S, Palma E, Gross J, Fisher J, Krumerman A.  Examination of explanted heart after radiofrequency ablation for intractable ventricular arrhythmia. Circ Arrhythm Electrophysiol. 2012;5(6):e109-10.


Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.


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