Faculty Profile

Dr. Wenfei Kang, Ph.D.

Wenfei Kang, Ph.D.

Visiting Associate, Dominick P. Purpura Department of Neuroscience

Professional Interests

Glial cells in the central nervous system, mainly including astrocytes, oligodendrocytes, microglia, and neural stem cells, are involved in diverse biological processes of CNS. Defects in glial cell functions are found to be associated with many common neurological disorders including neurodegenerative diseases and psychiatric diseases. I am particularly interested in the molecular regulation of glial cell functions in both physiological and pathological conditions with emphasis on astocytes and neural stem cells. For the study on astrocytes, my work focuses on the regulation of astrocyte-driven neuroinflammation by FGF signaling in both uninjured brain and injured brain. For the study on neural stem cells, molecular mechanisms that regulate adult neurogenesis and oligodendrogenesis in neurogenic niches of the brain are focused, aiming to identify means to improve repair and cell replacement in neurological disorders.   

Selected Publications

1. Kang W, Hebert JM (2015). FGF signaling is necessary for neurogenesis in young mice and sufficient to reverse its decline in old mice. Journal of Neuroscience 35(28):10217-23.
2. Kang W, Balordi F, Fishell, G and Hebert JM (2014). Astrocyte activation is suppressed in both normal and injured brain by FGF signaling. PNAS 111(29):E2987-95.
3. Diaz F, Mckeehan N, Kang W and Hebert JM (2013). Apoptosis of glutamatergic neurons fails to trigger a neurogenic response in the adult neocortex. Journal of Neuroscience 33(15):6278-84.
4. Kang W and Hebert JM (2012). A Sox2 BAC transgenic approach for targeting adult neural stem cells. PLoS One 7(11):e49038.
5. Khonsari RH, Delezoide AL, Kang W, Hébert JM, Bessières B, Bodiguel V, Collet C, Legeai-Mallet L, Sharpe PT, Fallet-Bianco C (2012). Central nervous system malformations and deformations in FGFR2-related craniosynostosis. Am J Med Genet A. 158A(11):2797-806.
6. Kang W, Hébert JM (2011). Signaling in reactive astrogliosis, a genetic perspective. Molecular Neurobiology 43: 147-154.
7. Kang W, Wong LC, Shi SH, Hébert JM. (2009). The transition from radial glial to intermediate progenitor cell is inhibited by FGF signaling during corticogenesis. Journal of Neuroscience 29:14571-80.
8. Qin J, Kang W, Mcleod M. (2003). Ste11p, a High-Mobility-Group Box DNA-binding Protein, Undergoes Pheromone- and Nutrient-Regulated Nuclear-Cytoplasmic Shuttling. Molecular and Cellular Biology 23:3253-3264.

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