Science at the heart of medicine

7031 Structural Molecular Biology

COURSE DESCRIPTION: Structural Molecular Biology seeks to provide a complete and coherent picture of biological phenomena at the molecular and atomic level. The goals include developing a comprehensive understanding of the molecular shapes and forms embraced by biological macromolecules and extending this knowledge to understand how different molecular architectures and mechanisms are used to perform the reactions and processes that are central to life.

Related processes will be included such as protein folding, protein dynamics, molecular modeling, drug design and computational biology. Central tools used in this research include X-ray diffraction, NMR, electron microscopy, small angle scattering, integrative approaches to larger systems, and simulation and experimental comparison using molecular dynamics. The course will be complimented by specific workshops on the technical aspects. In addition, students with specific interests will be guided to ancillary courses for deep immersion in detailed topics.

REQUIRED MATERIALS: Laptop

PREREQUISITES: Biochemistry

STUDENT PREPARATION:N/A

SUITABLE FOR 1ST YEAR STUDENTS: Yes

UNIQUE TRAINING OFFERED IN THIS COURSE:The overall objective is that students will be able to assess the literature in this area critically, and to design their own use of the covered methods to answer critical biomedical questions.

STUDENT ASSESSMENTS:Quizzes, Exam, Participation

CREDIT HOURS: 4.0