COURSE DESCRIPTION: The course will provide a gentle introduction to basic NMR theory, and a more thorough treatment of the application of NMR to solving biochemical problems. Topics will include one-, two-, and possibly 3-dimensional methods applied to: the covalent structure and conformation of small molecules and macromolecules, ligand binding and exchange rates, pKa values, and enzyme mechanisms. Three weekly discussion sessions based on assigned readings will be combined with hands-on sessions in the NMR lab, where students will be assigned projects to be completed on the NMR spectrometers.
REQUIRED MATERIALS: Access to a computer or laptop.
STUDENT PREPARATION: A general familiarity with organic chemistry and biochemistry.
SUITABLE FOR 1ST YEAR STUDENTS: Yes
UNIQUE TRAINING OFFERED IN THIS COURSE: This is a fairly practical, hands-on course on using high resolution solution NMR to answer chemical and biochemical questions. It does not overlap with it or any other course.
STUDENT ASSESSMENTS: Student learning will be assessed by problem sets, lab write-ups, and one exam.
CREDIT HOURS: 2.0