Science at the heart of medicine

7014 Molecular Approaches to Drug Action and Design

COURSE DESCRIPTION: As a society, where would we be without drugs? Antibiotics, chemotherapeutics and small molecules for the treatment of infections, cancer, diabetes, blood pressure, pain and a multitude of other conditions has allowed us to live longer, healthier and more productive lives. This course will involve in depth discussion of how some of our most impactful drugs were discovered or designed and their mechanisms of action. Modules will cover the principles of modern pharmacology (e.g. pharmacokinetics, pharmacodynamics, pharmacogenomics), methodologies of drug discovery/design and therapeutics for the treatment of cancer, metabolic diseases and infections. The course will also introduce the concept of aging as a drug target, with an overview of preclinical data and examples of how aging therapeutics are headed towards clinical use. Throughout, emphasis will be placed on the biology and chemistry of interactions between chemotherapeutic agents and their cellular targets, including specific enzymes, their cellular processes and the eventual development of resistance.

REQUIRED MATERIALS: N/A

PREREQUISITES: Undergraduate biochemistry or higher.

STUDENT PREPARATION: Thermodynamics, enzyme kinetics, protein structure and function, receptor ligand interactions.

SUITABLE FOR 1ST YEAR STUDENTS: Yes

UNIQUE TRAINING OFFERED IN THIS COURSE: I am not aware of any overlap between this course and other graduate courses at Einstein. Students will learn basic concepts central to pharmacology. In addition, a variety of cutting edge methods being employed to design new drugs by both academia and industry will be discussed. In addition, the course will survey a variety of major drugs and drug classes and their molecular mechanisms of action.

STUDENT ASSESSMENTS: There will be two take home exams (30% each) and team-based learning discussions (10%) and two group presentations (15% each).

CREDIT HOURS: 3.0