Science at the heart of medicine

7014 Molecular Approaches to Drug Action and Design

COURSE DESCRIPTION: This course will involve a discussion of drugs employed in the treatment of cancer, diabetes, cardiovascular, bacterial, viral, fungal, parasitic disease, and CNS pathology. The principles of pharmacokinetics, pharmacodynamics, and drug metabolism, and a variety of drug design methods will be studied. The molecular mechanisms of drug resistance will also be analyzed. Emphasis will be placed on the biology and chemistry of interactions between chemotherapeutic agents and their cellular targets, including specific enzymes and receptors, the cytoskeleton, cell membrane components, transport processes, DNA and the ribosome.

REQUIRED MATERIALS: N/A

PREREQUISITES: Undergraduate biochemistry or higher

STUDENT PREPARATION: Thermodynamics, enzyme kinetics, protein structure and function, receptor ligand interactions

SUITABLE FOR 1ST YEAR STUDENTS: Yes

UNIQUE TRAINING OFFERED IN THIS COURSE: I am not aware of any overlap between this course and other graduate courses at Einstein. Students will learn basic concepts central to pharmacology. In addition, a variety of cutting edge methods being employed to design new drugs by both academia and industry will be discussed. In addition, the course will survey a variety of major drugs and drug classes and their molecular mechanisms of action. 

STUDENT ASSESSMENTS: There will be two take home exams (35% each) and two group presentations (15% each)

CREDIT HOURS: 3.0