Science at the heart of medicine

7016 Glycobiology

COURSE DESCRIPTION: This course will introduce students to known biological roles for the major classes of glycans on glycoproteins and glycolipids

REQUIRED MATERIALS: Online textbook "Essentials of Glycobiology", laptop computer to access the internet in class.

PREREQUISITES: Undergraduate Biochemistry or Chemistry.

STUDENT PREPARATION: Students should read the Introductory chapter to the online textbook in Pubmed "Essentials of Glycobiology" by Varki et al., (2009)


UNIQUE TRAINING OFFERED IN THIS COURSE: Glycobiology is a relatively new area often bypassed in undergraduate curricula. There are now many clearly defined functions for glycans and mechanisms by which they act are known. The majority of proteins in the secretory pathway are glycosylated and many cytosolic and nuclear proteins are modified by O-GlcNAc. There are many diseases known to originate in defective glycosylation. Basic concepts will be taught from the textbook "Essentials of Glycobiology". However, areas of focus will depend on the scientific interests of participating students. Overlap with Biochemistry or Molecular Cell Biology will be minimal or non-existent. There will be a strong emphasis on biological relevance and how to define functional roles for glycans in biology. Outside seminar speaker(s) will be invited to speak on related topics in the Cell Biology seminar series. Faculty with expertise in Glycobiology including Hannes Buelow, Peng Wu and Fred Brewer will be asked to participate depending on the topic.

STUDENT ASSESSMENTS: Critique of a paper from the literature and a take home exam.

NOTE: In order for this course to be given a (minimum of 4 students) must be registered.