Science at the heart of medicine

7004 Biophysical Methods

COURSE DESCRIPTION: The goal of Human Metabolism: Regulation and Disease is to provide students with an understanding of the principles of the interrelated pathways of human metabolism and the ability to apply those principles to discussion of the pathophysiology and the design of new therapies for human disease. The course combines lecture, self-study and weekly small group student-led discussions of contemporary literature relevant to the lecture topics.

REQUIRED MATERIALS: Students are requested to obtain a copy of the 6th edition of Thomas M. Devlin (ed) Textbook of Biochemistry With Clinical Correlations that is used by several of the lecturers. Used copies of this textbook are available online for less than $10.

PREREQUISITES: A passing grade in, or exemption from, course 7001, Biochemistry, is required.

STUDENT PREPARATION: The student should be conversant in the basic concepts of biochemistry that are presented in the Biochemistry course prerequisite. These include, but are not limited to a familiarity with the fundamental biochemical species of amino acids, lipids, oligosaccharides and nucleic acids, biochemical energetics, the fundamental energy-producing biochemical pathways, enzymatic catalysis and enzyme regulation.


UNIQUE TRAINING OFFERED IN THIS COURSE: The course is both an extension of Biochemistry taught during Block 1 as well as an opportunity for students to develop a more cohesive view of the nature and regulation of human metabolism. The course will cover key areas in metabolism and will highlight relationships to clinically relevant topics and the integration and regulation of carbohydrate, lipid, amino acid and nucleic acid metabolism.

STUDENT ASSESSMENTS: Student learning will be assessed with two in-class examinations and participation in the small group discussions. Attendance at, and active participation in, the small group discussions is mandatory.