“Extreme cellular adaptation”
Saeed Tavazoie, Ph.D.
Department of Biochemistry and Molecular Biophysics & Department of Systems Biology
Monday, April 24, 2017
Abstract: The ability to adapt to changes in the external environment is a defining capacity of cellular life. As such, dedicated signaling pathways and regulatory networks have evolved to detect changes in the parameters of the external world and to reprogram gene expression in order to achieve internal homeostasis. However, dedicated sensory and regulatory networks are inadequate when cells are exposed to novel extreme environments that are foreign to their evolutionary history. Our recent work has revealed new insights into genetic and epigenetic mechanisms by which cells meet this critical challenge. Our findings have important implications for cellular fitness and survival on both physiological and evolutionary timescales.