Department of Physiology and Biophysics

Publication Highlights

Publication Highlights in 2009

  Riegelhaupt PM, Cassera MB, Fröhlich RF, Hazleton KZ, Hefter JJ, Schramm VL, Akabas MH. Transport of Purines and Purine Salvage Pathway Inhibitors by the Plasmodium falciparum Equilibrative Nucleoside Transporter PfENT1. Mol Biochem Parasitol. 2010 Jan; 169(1):40-9.
  Martinez LR, Mihu MR, Han G, Frases S, Cordero RJ, Casadevall A, Friedman AJ, Friedman JM, Nosanchuk JD. The use of chitosan to damage Cryptococcus neoformans biofilms. Biomaterials. 2010 Feb; 31(4):669-79.  
  Guo F, Friedman JM. Osmolyte-Induced Perturbations of Hydrogen Bonding between Hydration Layer Waters: Correlation with Protein Conformational Changes. J Phys Chem B. 2009 Dec 4. [Epub ahead of print]
  Egawa T, Lin MT, Hosler JP, Gennis RB, Yeh SR, Rousseau DL. Communication between R481 and Cu(B) in Cytochrome bo3 Ubiquinol Oxidase from Escherichia coli. Biochemistry. 2009 Dec 3. [Epub ahead of print]
  Udho E, Jakes KS, Buchanan SK, James KJ, Jiang X, Klebba PE, Finkelstein A. Reconstitution of bacterial outer membrane TonB-dependent transporters in planar lipid bilayer membranes. Proc Natl Acad Sci U S A. 2009 Dec 3. [Epub ahead of print]
  Wu H, Shekar SC, Flinn RJ, El-Sibai M, Jaiswal BS, Sen KI, Janakiraman V, Seshagiri S, Gerfen GJ, Girvin ME, Backer JM. Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20258-63.
  Jakes KS, Finkelstein A. The colicin Ia receptor, Cir, is also the translocator for colicin Ia. Mol Microbiol. 2009 Nov 17. [Epub ahead of print]
  Roche CJ, Friedman JM. NO reactions with sol-gel and solution phase samples of the ferric nitrite derivative of HbA. Nitric Oxide. 2009 Nov 15. [Epub ahead of print]
  Nickel E, Nienhaus K, Lu C, Yeh SR, Nienhaus GU. Ligand and substrate migration in human indoleamine 2,3-dioxygenase. J Biol Chem. 2009 Nov 13;284(46):31548-54.
  Han G, Martinez LR, Mihu MR, Friedman AJ, Friedman JM, Nosanchuk JD. Nitric oxide releasing nanoparticles are therapeutic for Staphylococcus aureus abscesses in a murine model of infection. PLoS One. 2009 Nov 12; 4(11):e7804.
  Egawa T, Lee HJ, Ji H, Gennis RB, Yeh SR, Rousseau DL. Identification of heme propionate vibrational modes in the resonance Raman spectra of cytochrome c oxidase. Anal Biochem. 2009 Nov 1;394(1):141-3. Epub 2009 Jun 27.
  Prado CM, Fine EJ, Koba W, Zhao D, Rossi MA, Tanowitz HB, Jelicks LA. Micro-positron emission tomography in the evaluation of Trypanosoma cruzi-induced heart disease: Comparison with other modalities. Am J Trop Med Hyg. 2009 Nov;81(5):900-5.
  Rath U, Rogers GC, Tan D, Gomez-Ferreria MA, Buster DW, Sosa HJ, Sharp DJ. The Drosophila kinesin-13, KLP59D, impacts Pacman- and Flux-based chromosome movement. Mol Biol Cell. 2009 Nov;20(22):4696-705.
  Lewis-Ballester A, Batabyal D, Egawa T, Lu C, Lin Y, Marti MA, Capece L, Estrin DA, Yeh SR. Evidence for a ferryl intermediate in a heme-based dioxygenase. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17371-6.
  Sharp DJ, Rath U. Mitosis: KLP61F goes wee! Curr Biol. 2009 Oct 13;19(19):R899-901.
  Egawa T, Lee HJ, Gennis RB, Yeh SR, Rousseau DL. Critical structural role of R481 in cytochrome c oxidase from Rhodobacter sphaeroides. Biochim Biophys Acta. 2009 Oct;1787(10):1272-5.
  Schweitzer AD, Howell RC, Jiang Z, Bryan RA, Gerfen G, Chen CC, Mah D, Cahill S, Casadevall A, Dadachova E. Physico-chemical evaluation of rationally designed melanins as novel nature-inspired radioprotectors. PLoS One. 2009 Sep 30;4(9):e7229.
  Lu C, Lin Y, Yeh SR. Inhibitory substrate binding site of human indoleamine 2,3-dioxygenase. J Am Chem Soc. 2009 Sep 16; 131(36):12866-7.
  Sabat J, Stuehr DJ, Yeh SR, Rousseau DL. Characterization of the proximal ligand in the P420 form of inducible Nitric Oxide Synthase. J Am Chem Soc. 2009 Sep 2; 131(34):12186-92.
  Navati MS, Friedman JM. Reactivity of glass-embedded met hemoglobin derivatives toward external NO: implications for nitrite-mediated production of bioactive NO. J Am Chem Soc. 2009 Sep;131(34):12273-9.
  Mennella V, Tan DY, Buster DW, Asenjo AB, Rath U, Ma A, Sosa HJ, Sharp DJ. Motor domain phosphorylation and regulation of the Drosophila kinesin 13, KLP10A. J Cell Biol. 2009 Aug 24;186(4):481-90.
  Wainman A, Buster DW, Duncan T, Metz J, Ma A, Sharp D, Wakefield JG. A new Augmin subunit, Msd1, demonstrates the importance of mitotic spindle-templated microtubule nucleation in the absence of functioning centrosomes. Genes Dev. 2009 Aug 15;23(16):1876-81.
  Guo F, Friedman JM. Charge density-dependent modifications of hydration shell waters by Hofmeister ions. J Am Chem Soc. 2009 Aug 12;131(31):11010-8.
  Vergara A, Franzese M, Merlino A, Bonomi G, Verde C, Giordano D, di Prisco G, Lee HC, Peisach J, Mazzarella L. Correlation between hemichrome stability and the root effect in tetrameric hemoglobins. Biophys J. 2009 Aug 5;97(3):866-74.
  Schwartz SD, Schramm VL. Enzymatic transition states and dynamic motion in barrier crossing. Nat Chem Biol. 2009 Aug;5(8):551-8.
  Guinto PJ, Haim TE, Dowell-Martino CC, Sibinga N, Tardiff JC. Temporal and mutation-specific alterations in Ca2+ homeostasis differentially determine the progression of cTnT-related cardiomyopathies in murine models. Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H614-26.
  Nagajyothi F, Desruisseaux MS, Jelicks LA, Machado FS, Chua S, Scherer PE, Tanowitz HB. Perspectives on adipose tissue, chagas disease and implications for the metabolic syndrome. Interdiscip Perspect Infect Dis. 2009;2009:824324. Epub 2009 Jul 26.
  Hartil K, Vuguin PM, Kruse M, Schmuel E, Fiallo A, Vargas C, Warner MJ, Durand JL, Jelicks LA, Charron MJ. Maternal Substrate Utilization Programs the Development of the Metabolic Syndrome in Male Mice Exposed to High Fat in Utero. Pediatr Res. 2009 Jul 1. [Epub ahead of print]
  Campos de Carvalho AC, Goldenberg RC, Jelicks LA, Soares MB, Dos Santos RR, Spray DC, Tanowitz HB. Cell Therapy in Chagas Disease. Interdiscip Perspect Infect Dis. 2009;2009:484358. Epub 2009 Jun 11.
  Pietri R, Lewis A, León RG, Casabona G, Kiger L, Yeh SR, Fernandez-Alberti S, Marden MC, Cadilla CL, López-Garriga J. Factors controlling the reactivity of hydrogen sulfide with hemeproteins. Biochemistry. 2009 Jun 9;48(22):4881-94.
  Nkrumah LJ, Riegelhaupt PM, Moura P, Johnson DJ, Patel J, Hayton K, Ferdig MT, Wellems TE, Akabas MH, Fidock DA. Probing the multifactorial basis of Plasmodium falciparum quinine resistance: evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE. Mol Biochem Parasitol. 2009 Jun;165(2):122-31.
  Tanowitz HB, Machado FS, Jelicks LA, Shirani J, de Carvalho AC, Spray DC, Factor SM, Kirchhoff LV, Weiss LM. Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease). Prog Cardiovasc Dis. 2009 May-Jun;51(6):524-39.
  Li Y, Qu X, Ma A, Smith GJ, Scherer NF, Dinner AR. Models of single-molecule experiments with periodic perturbations reveal hidden dynamics in RNA folding. J Phys Chem B. 2009 May 28;113(21):7579-90.
  Colaneri MJ, Vitali J, Peisach J. Aspects of structure and bonding in copper-amino acid complexes revealed by single-crystal EPR/ENDOR spectroscopy and density functional calculations. J Phys Chem A. 2009 May 14;113(19):5700-9.
  Fernandez N, Chang Q, Buster DW, Sharp DJ, Ma A. A model for the regulatory network controlling the dynamics of kinetochore microtubule plus-ends and poleward flux in metaphase. Proc Natl Acad Sci U S A. 2009 May 12;106(19):7846-51.
  Durand JL, Mukherjee S, Commodari F, De Souza AP, Zhao D, Machado FS, Tanowitz HB, Jelicks LA. Role of NOS in the development of Trypanosoma cruzi-induced cardiomyopathy in mice. Am J Trop Med Hyg. 2009 May;80(5):782-7.
  Martinez LR, Han G, Chacko M, Mihu MR, Jacobson M, Gialanella P, Friedman AJ, Nosanchuk JD, Friedman JM. Antimicrobial and Healing Efficacy of Sustained Release Nitric Oxide Nanoparticles Against Staphylococcus aureus Skin Infection. J Invest Dermatol. 2009 Apr 23. [Epub ahead of print]
  Antoniou D, Schwartz SD. The stochastic separatrix and the reaction coordinate for complex systems. J Chem Phys. 2009 Apr 21;130(15):151103.
  Asenjo AB, Sosa H. A mobile kinesin-head intermediate during the ATP-waiting state. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5657-62.
  Gelman D, Schwartz SD. Modeling vibrational resonance in linear hydrocarbon chain with a mixed quantum-classical method. J Chem Phys. 2009 Apr 7;130(13):134110.
  Giordano D, Boechi L, Vergara A, Martí MA, Samuni U, Dantsker D, Grassi L, Estrin DA, Friedman JM, Mazzarella L, di Prisco G, Verde C. The hemoglobins of the sub-Antarctic fish Cottoperca gobio, a phyletically basal species--oxygen-binding equilibria, kinetics and molecular dynamics. FEBS J. 2009 Apr;276(8):2266-77.
  Suarez J, Ranguelova K, Jarzecki AA, Manzerova J, Krymov V, Zhao X, Yu S, Metlitsky L, Gerfen GJ, Magliozzo RS. An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG). J Biol Chem. 2009 Mar 13;284(11):7017-29.
  Bali M, Jansen M, Akabas MH. GABA-induced intersubunit conformational movement in the GABAA receptor alpha 1M1-beta 2M3 transmembrane subunit interface: experimental basis for homology modeling of an intravenous anesthetic binding site. J Neurosci. 2009 Mar 11;29(10):3083-92.
  Basilio D, Juris SJ, Collier RJ, Finkelstein A. Evidence for a proton-protein symport mechanism in the anthrax toxin channel. J Gen Physiol. 2009 Mar;133(3):307-14.
  Wittenberg BA. Both hypoxia and work are required to enhance expression of myoglobin in skeletal muscle. Focus on "Hypoxia reprograms calcium signaling and regulates myoglobin expression". Am J Physiol Cell Physiol. 2009 Mar;296(3):C390-2
  Egawa T, Durand JL, Hayden EY, Rousseau DL, Yeh SR. Design and evaluation of a passive alcove-based microfluidic mixer. Anal Chem. 2009 Feb 15;81(4):1622-7.
  Batabyal D, Yeh SR. Substrate-Protein Interaction in Human Tryptophan Dioxygenase: The Critical Role of H76. J Am Chem Soc. 2009 Feb 11; 131 (9), 3260-70.
  Yeh HC, Gerfen GJ, Wang JS, Tsai AL, Wang LH. Characterization of the peroxidase mechanism upon reaction of prostacyclin synthase with peracetic acid. Identification of a tyrosyl radical intermediate. Biochemistry. 2009 Feb 10;48(5):917-28.
  Janowiak BE, Finkelstein A, Collier RJ. An approach to characterizing single-subunit mutations in multimeric prepores and pores of anthrax protective antigen. Protein Sci. 2009 Feb;18(2):348-58.
  Guallar V, Lu C, Borrelli K, Egawa T, Yeh SR. Ligand migration in the truncated hemoglobin-II from Mycobacterium tuberculosis: the role of G8 tryptophan. J Biol Chem. 2009 Jan 30;284(5):3106-16.
  Wang JC, Kwong S, Ferrone FA, Turner MS, Briehl RW. Fiber depolymerization: fracture, fragments, vanishing times, and stochastics in sickle hemoglobin. Biophys J. 2009 Jan;96(2):655-70.
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